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Biomedical subjects

T Tsuboi

Publications and source records attributed to T Tsuboi.

At least 127 records · Page 7Linked to original sources
PubMed1985

EEG abnormalities in nonepileptic patients.

A total of 202 nonepileptic patients (120 males and 82 females) who exhibited spike abnormalities at least twice in their EEG examinations were studied. The incidence of spike abnormalities among nonepileptic patients was 8.1% (847/10,473). The majority (90%) were under age 19. Headache, dizziness and vomiting, and abdominal pain were more frequently observed compared with controls. Mild paroxysmal EEG abnormalities such as diffuse irregular slow wave bursts with spike (27%), positive spikes (25%) or small spike (8.4%) were commonly detected. In three patients who developed epileptic seizures during the follow-up period, more specific EEG abnormalities were often exhibited. Other factors like the age at onset before 9, characteristic clinical symptoms or a positive family history of seizures were confirmed to be necessary for the manifestation of clinical seizures.

Age Factors↗
PubMed1985

Electroencephalographic examination of 64 Danish Turner girls.

An EEG study of 64 Danish Turner girls and age-matched controls was made. The characteristic findings in the basic EEG rhythms of Turner girls were: 1) alpha activity of more rapid frequency (10.5+ Hz), lower amplitude (-20 microV, lower amount (-30%) and diffuse areas, 2) beta activity of slower frequency (14-18 Hz), higher amplitude (10-20+ microV), higher amount (50+ %) and diffuse areas, and 3) theta activity of higher amount (30+ %) than controls. Dominant EEG rhythm was more rapid and aging effect was more pronounced in Turner girls than in the controls. Marked or moderate asymmetry was observed in 15 Turner girls compared with three controls (p less than 0.01). Asymmetry was most pronounced at the occipital (p less than 0.01) and parietal area (p less than 0.02), but not so at the frontal, temporal or central areas. In 64 Turner girls, paroxysmal EEG abnormality was found in one, paroxysmal, slight abnormality in 13, basic abnormality in three and normal/borderline in 47. The EEG diagnosis did not differ in Turner and control girls. The characteristic findings in the basic EEG rhythm and dominant rhythm were more pronounced in Turner girls with 45,X than in those with other karyotypes, who showed some similarity to the controls. Our findings indicate that Turner girls have a functional brain disorder more often than the controls, particularly at the occipital and parietal areas and in those with hemispheric differences most often in the right hemisphere. Further studies comprising 24-h EEG investigation and blood flow studies were suggested.

Adolescent↗
PubMed1985

Exogenous causes of seizures in children: a population study.

Of many exogenous causes, difficult birth, neonatal asphyxia, and coiling of the umbilical cord might be identified as risk factors predicting an initial febrile convulsion. Children with febrile convulsions and exogenous causes are likely to have affected family members, and have a risk of recurrence of seizures on 5 occasions or more. Exogenous causes alone barely raise the risk of recurrence of febrile convulsions after 3 years of age or development of afebrile convulsions. The incidence of exogenous causes is highest in children who develop afebrile convulsions after febrile convulsions, and lowest in children who experience only febrile convulsions, although a little higher than in normal controls.

Asphyxia Neonatorum↗
PubMed1985

[Experimental studies on combination chemotherapy based on cell cycle analysis].

Based on Peplomycin-induced cell cycle distribution analyzed by a flow-cytemetry using HeLa S-3 and SNG-M cells in vitro, we investigated reasonable periods and kinds of drug combined with pepleomycin (PEP). Changes in both the PEP treatment time and dosage produced a redistribution which decreases the number of cells in the G1 phase and increased the number of cells in the S and G2-M phases. The period with the maximum number of cells in the S phase was 12 hours in the HeLa S-3 and 16 hours in the SNG-M and, that in the G2-M phases, 16 hours in the HeLa S-3 and 22 hours in the SNG-M after the treatment. In the combination of the pep with CIS-DDP 4-hydroperoxy cyclophosphamide Adriamycin (ADR) and ACNU, the cytotoxic potency of the four drugs were CIS-DDP greater than 4-Hydroperoxy cyclophosphamide greater than ADR greater than ACNU in the HeLa S-3 and 4-Hydroperoxy cyclophosphamide greater than CIS-DDP greater than ADR greater than ACNU in the SNG-M. This suggests that the Cis and 4-Hydroperoxy cyclophosphamide were adequate for the combination with the PEP. The period of the combination should be at the time of the greatest accumulation of cells in the G2-M phase, because the pep effectively produced the G2-M partial synchronization. These results suggest that the combination chemotherapy should be based on the analysis of the cell cycle.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1984

Pharmacokinetic analysis of plasma concentration and urinary excretion of sulphamonomethoxine and its metabolite in Goettingen minipigs.

The plasma concentration and renal excretion after a bolus intravenous injection of a low (10 mg/kg) or high (100 mg/kg) dose of sulphamonomethoxine (SMM) were studied in five Goettingen minipigs. The time data of plasma concentration after a low dose decreased rapidly and appeared to be linear on semilog graph paper. On the other hand, a decrease in the plasma concentration after a high dose was slow at first, gradually accelerated, then became rapid, showing that SMM disposition after a high dose (100 mg/kg) seemed to be non-linear with capacity-limited elimination. A large amount of the acetyl derivative of SMM (AcSMM), which was determined to be the main excretory product of SMM in urine, was detected in the plasma after SMM injection. As the ratios of the area under plasma concentration-time curve of AcSMM to that of SMM were not significantly different at either dose, the acetylation of SMM may be unsaturable by injection of 100 mg/kg of SMM. Immediately after the injection of a low dose, a rapid hyperbolic increase of the fraction of the cumulative amount of the excretory products in urine was observed. On the other hand, the fraction curve at the high dose rose slowly at first, then rapidly and hyperbolically. These results suggested that the non-linear drug disposition after a high dose (100 mg/kg) of SMM in pigs may be the result of a limited capacity for renal excretion of SMM and excretory products, especially the acetyl derivative.

Animals↗
PubMed1984

Seasonal variation of febrile convulsion in Japan.

The 6-year incidence rates of febrile convulsions in all 3-year-old children in Fuchu (covering 95% of children, number examined 17,044) was 8.2%. The incidence was higher in boys than in girls (9.0%: 7.5%, P less than 0.001). The incidence rates varied with the month and year of birth, but the variations observed were slight. Two peak appearances of seasonal variation of the first febrile convulsion were found in November-January and in June-August. The former could be interpreted as a tendency to winter virus infection of the upper respiratory tract in children. The other peak in summer could be explained as a tendency to gastrointestinal infection. Liability to febrile convulsion was influenced by the age of children and by the seasonal variations of febrile illness, but not by the season of birth.

Age Factors↗
PubMed1984

Epidemiology of febrile and afebrile convulsions in children in Japan.

Prevalence rates in all 3-year-old children in Fuchu/Tokyo, for a 6-year survey from 1974 to 1980 (total number examined, 17,044), were 8.3% for febrile convulsion and 0.9% for afebrile convulsion. The figures in boys were higher than in girls for febrile convulsion (9.0%:7.5%), but for afebrile convulsion (0.9%:0.9%). Prevalence in a Miyake Island survey for 10 years, from 1973 to 1982 (total number examined, 543) was 9.9% for febrile and 0.4% for afebrile convulsion. Correlations among prevalence of febrile convulsion, epilepsy, and epileptic EEG abnormality in healthy children were inconsistent in geographically isolated villages identified in Miyake Island.

Child, Preschool↗
PubMed1983

Biological effects of Spirometra erinacei plerocercoids in several species of rodents.

Observations were made of the biological effects on infection with plerocercoids of Spirometra erinacei on normal female Snell mice, male chinese hamsters, golden hamsters, normal and hypox rats. Plerocercoid infection caused the strongest growth-promoting effect on normal Snell mice. In mice, this effect appears to be independent of strain. Chinese hamsters infected with these larvae showed similar growth. The infected normal rats and golden hamsters, however, showed a weight increase in the skeletal muscle only, while the hypox rats exhibited no effect at all. The elevation in the concentration of serum triglyceride was observed in all the animals investigated except for rats. Golden hamsters, in particular, exhibited a marked increase in the concentration of serum free fatty acids and total cholesterol. There was close correlation between the concentrations of serum triglyceride and free fatty acids, and the regression coefficient of the resulting linear regression equation for the experimentals was higher than that for the controls. This suggests that serum triglyceride results from an increased concentration of serum free fatty acids derived from stimulated lipolysis. The total cholesterol concentration in the serum decreased in chinese hamsters infected with larvae. The serum glucose concentration increased in normal Snell mice but decreased in chinese and golden hamsters. No difference in glycerol and free fatty acid concentration was observed in infected animals except for golden hamsters.

Animals↗
PubMed1983

Effects of Spirometra erinacei plerocercoids on the growth of Snell dwarf mice.

Snell normal and dwarf mice were infected with Spirometra erinacei plerocercoids collected in Japan, to investigate the relationship between the growth-promoting effects of plerocercoids and the growth hormone releasing factor and the somatostatin--growth hormone--somatomedin axis in the host. Infection with plerocercoids caused increases in body weight and weights of muscle, liver, spleen and heart in the normal male mice, and increases in the head--body length, body weight and weights of muscle, liver, spleen, kidney and heart in the normal female mice, but did not increase the weight of the fat pad. Infection with plerocercoids caused increases in body weights and weights of muscle, liver and spleen in the male dwarf mice, and increases in the head--body length, body weight and weights of muscle, liver, spleen and kidney in the female dwarf mice. These observations suggest that plerocercoids promote the growth of dwarf mice as well as normal mice. As the dwarfism of Snell mice is due to a defective anterior pituitary gland, it seems that plerocercoids do not stimulate secretion of growth hormone from the pituitary. Accordingly, it seems to be more probable that the larvae secrete a growth hormone-like substance.

Animals↗
PubMed1983

Effect of gliclazide on prostaglandin I2 formation in normal and streptozotocin-induced diabetic animals.

The effect of gliclazide, a hypoglycemic sulfonylurea, on the formation of prostaglandin (PG) I2 by the aortic rings of normal and streptozotocin-induced diabetic animals was studied. In in vitro experiments, gliclazide (100-300 micrograms/ml) enhanced the spontaneous PGI2 formation by the guinea-pig and rat aorta. Gliclazide also enhanced the transformation of both arachidonic acid and PGH2 to PGI2 in guinea-pig aorta, indicating that one of the main enhancing sites is the step of converting PGH2 to PGI2. In ex vivo experiments, the formation of PGI2 in the aorta of streptozotocin-diabetic rats was markedly reduced as compared with that of normal rats. An oral administration of gliclazide (100-300 mg/kg) significantly restored this reduced formation of PGI2 without any effect on blood glucose level. This enhancing effect of gliclazide may be favorable to the treatment of diabetic microangiopathy.

Animals↗
PubMed1982

[Enhancement of platelet function in cholesterol-fed guinea-pigs].

Effects of cholesterol-loading on platelet functions were studied. Guinea-pigs were fed on a diet containing 1% cholesterol for 1--5 months. Cholesterol-feeding caused an elevation of cholesterol content in the plasma and platelets, although the phospholipids increased only in the plasma. Enhanced platelet aggregation induced by ADP, collagen, and arachidonic acid was maintained for 5 months during cholesterol-feeding, concomitant with an increase in malondialdehyde production in platelets. Although basal levels of platelet cyclic AMP were not affected, PGE1-stimulated cyclic AMP levels were markedly decreased in platelets of cholesterol-fed animals. The same results were observed in platelets treated with theophylline. No change in the generation of PGI2-like substance by the aortic tissue occurred during 4 months of cholesterol-feeding, though a significant increase was seen after 5 months. These results suggest that the enhancement of platelet function by cholesterol-feeding is concerned with enhanced prostaglandin synthesis and suppressed adenylate cyclase activity in platelets.

Animals↗
PubMed1982

Irradiation-induced changes in nuclear shape and cell cycle.

Using human uterine cervical carcinoma cells transplanted in nude mice and mice leukemia L5178Y cells, changes in the cell cycle following irradiation were observed by flow cytometry (FCM), and changes in the cell nuclei during the course of irradiation were measured by FCM. Experiments in vivo as well as in vitro caused accumulation of cells in the G2 to M populations, resulting in the so-called G2 block phenomenon as revealed by FCM analysis of DNA distributions. The radiation-induced changes of nuclear shapes were dependent on abnormal mitoses, which occurred more frequently in the G2 to M phases. Therefore it is suggested that the G2 block phenomenon plays an important role in radiation-induced cell death because the process of cell death by irradiation has been shown to proceed via these abnormal mitoses.

Animals↗