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Biomedical subjects

T Tuvemo

Publications and source records attributed to T Tuvemo.

138 records · Page 8Linked to original sources
PubMed1975

Reduction of the tone of the isolated human umbilical artery by indomethacin, eicosa-5,8,11,14-tetraynoic acid and polyphloretin phosphate.

The effects of 2 prostaglandin synthetase inhibitors, indomethacin and eicosa-5,8,11,14-tetraynoic acid (ETA) and of the prostaglandin antagonist, polyphloretin phosphate (PPP), on the tone of the isolated human umbilical artery and on the responses of this preparation to 5-hydroxytryptamine (5-HG) and prostaglandin F2alpha (PGF2alpha) were investigated. Indomethacin (8 mug/ml), ETA (5 mug/ml) or PPP (40 mug/ml) reduced the tone of human umbilical arteries but had no influence on the responses to 5-HT. In these concentrations ETA and PPP but not indomethacin antagonized the action of PGF2alpha. When the concentration of indomethacin or PPP was increased 5-fold both 5-HT- and PGF2alpha-induced contractions were antagonized indicating a non-specific inhibition at these concentration levels. A 10-fold increase in the concentration of ETA had no antagonizing action on 5-HT-induced contractions suggesting a more selective inhibition of the PGF2alpha action than displayed by the other compounds. The effects on the tone of the human umbilical artery of the compounds studied might reflect inhibition of prostaglandin biosynthesis and/or antagonism of the action of formed prostaglandins. The findings are compatible with the view that intramural synthesis of prostaglandins contributes to the maintenance of the tone of the isolated human umbilical artery.

5,8,11,14-Eicosatetraynoic Acid↗
PubMed1975

Effects and interactions of oxygen and prostaglandins on the tone of the isolated human umbilical artery.

Prostaglandin E2 (PGE2) and prostaglandin F2alpha (PGF2alpha) were found to be equipotent contractors of the isolated human umbilical artery (HUA) in the concentration range 0.2-40 mug/ml. Prostaglandin E1 (PGE1) relaxed HUA at 0.1-3.0 mug/ml, whereas at 10-50 mug/ml contraction occurred. PGE2 was significantly more potent at a PO2 of 102 mmHg than at 27, 48 and above 400 mmHg. An increase in PO2 per se (27- greater than 400 mmHg) resulted occasionally in minor increases in the tone of the HUA. Such effects of oxygen had a lag period of 10-15 min. It is suggested that an increased formation of prostaglandins in the umbilical artery at birth is a more likely cause of the closure of the vessel than an increase in PO2.

Drug Interactions↗
PubMedDate not supplied

Menarcheal age and growth pattern of Indian girls adopted in Sweden. II. Catch-up growth and final height.

Adopted girls (n = 107) previously studied regarding menarcheal age in relation to age at arrival, were analysed as to growth pattern and final height related to nutritional status at arrival and menarcheal age. It was found that most girls had catch-up growth regarding height and half of them regarding weight. Faster catch-up and later arrival age in Sweden were associated with earlier menarche. The catch-up growth was, however, incomplete, and lower the initial height for age, lower was the height for age at the succeeding measurements, and the final height. The mean final height was 154 cm, but 8% of the girls were 145 cm or shorter. The data suggest that linear growth and final height is influenced by the preadoptive nutritional condition, as well as by the degree and timing of subsequent catch-up growth, and the timing of puberty. Pubertal onset is related to the degree and timing of catch-up growth.

Adult↗
PubMedDate not supplied

Magnesium and insulin-dependent diabetes mellitus.

There is accumulating evidence that the changes which occur in the metabolism of some micronutrients in diabetes mellitus might have a specific role in the pathogenesis and complications of this disease. Magnesium deficiency is the most evident disturbance of metal metabolism in insulin-dependent diabetes mellitus. Hypomagnesemia has been linked both to the acute metabolic and late chronic complication of diabetes. Of particular concern, is the association between hypomagnesemia and ischemic heart disease and severe retinopathy in humans with diabetes mellitus. Appropriate magnesium supplementation might prove beneficial in normalizing the low plasma and tissue magnesium levels and prevent or retard the development of vascular complications in diabetic patients. However, well designed and documented experiments need to be performed before the rationales for such therapy are well established.

Coronary Disease↗
PubMedDate not supplied

Menarcheal age and growth pattern of Indian girls adopted in Sweden. I. Menarcheal age.

The median menarcheal age of 107 girls adopted from India by families in Sweden was 11.6 years, which was significantly lower than in Swedish and most Indian studies. Five girls had menarche before the age of 9 years, the earliest at 7.3 years. Those who arrived at a later age had earlier menarche. No differences in menarcheal age were found with respect to geographic origin. The reasons for the earlier pubertal maturation are not clear. Factors associated with the rapid transition from an underprivileged to a privileged environment are probably involved, besides genetic determinants. The serious medical, social and emotional consequences of very early pubertal development necessitate further clarification of the underlying mechanisms.

Adolescent↗
PubMedDate not supplied

The role of trace elements in juvenile diabetes mellitus.

There is accumulating evidence that the metabolism of several trace elements is altered in insulin-dependent diabetes mellitus and that these nutrients might have specific roles in the pathogenesis and progress of this disease. Magnesium deficiency is the most evident disturbance of metal metabolism in diabetes mellitus. Hypomagnesemia might increase the risk of ischemic heart disease and severe retinopathy. Increased urinary loss of zinc is a commonly encountered feature of diabetes. High-dose oral zinc might enhance wound healing, although data regarding diabetes are lacking. Chromium increases tissue sensitivity to insulin and tends to raise high-density lipoprotein (HDL) cholesterol and the HDL:low-density lipoprotein ratio. Selenium is involved in processes which protect the cell against oxidative damage by peroxides produced from lipid metabolism. There is one report of elevated serum selenium in diabetic children although the clinical significance of this finding is still unclear. An insulin-like effect has recently been attributed to vanadium in experimental animals, a finding of potential interest to man. Current knowledge does not implicate iron, iodine, manganese, cobalt, nickel, silicone, fluoride, molybdenum or tin in the pathophysiology of diabetes. Appropriate trace element supplementation might prove beneficial in ameliorating some physiological deficiencies associated with diabetes and prevent or retard secondary complications. However, properly designed and well-documented trials, especially on magnesium supplementation, need to be performed before rationales for such supplementation are developed. The potential roles of vanadium, chromium and selenium in diabetes constitute challenging areas for further experimental and clinical research.

Animals↗