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T Ueda

Publications and source records attributed to T Ueda.

At least 1,135 records · Page 63Linked to original sources
PubMed1989

Heterogeneous features of Ph-negative CML--possible existence of Ph-negative, bcr-rearrangement-negative CML.

We have examined eight patients with Ph-negative chronic myelocytic leukemia (CML). Two of the patients had the same molecular abnormalities as well as the same clinical and hematological features as those of Ph-positive CML. The other six patients showed no genomic rearrangement. This group was hematologically divided into four subgroups, namely chronic myelomonocytic leukemia, undifferentiated chronic myeloproliferative disorder, chronic neutrophilic leukemia and CML-like syndrome. This last subgroup resembled Ph-positive CML in many points except for rather moderate proliferation of granulocyte lineage, and it was difficult to clinically separate it from Ph-positive CML.

Adult↗
PubMed1989

[Clinical characteristics of unstable angina in 162 consecutive cases].

We surveyed the clinical characteristics, treatment, and prognosis of 162 patients with unstable angina, who were admitted to our center between 1985 and 1987. There were 112 males and 50 females, with a mean age of 65 years. The clinical characteristics according to the American Heart Association classification were new angina of effort in 21%, changing pattern in 61%, and new angina at rest in 18% of the patients. ECG recordings during attacks of angina were obtained in 70%, and ST elevation was detected in 11%, ST depression in 54%, and T wave abnormality in 5%. Coronary arteriography performed in 42% of the patients revealed single vessel lesion in 21%, two vessel lesion in 10%, three vessel lesion in 5%, and left main trunk lesion in 3% of the patients. Seventy-seven percent of the patients were controlled by medical therapy, including nitrates, calcium antagonists, and, in some cases, beta blockades. Three percent of the patients were controlled with intra aortic balloon pumping in addition to medical therapy. Coronary artery bypass graft surgery (CABG) was performed in 6% of the patients. Since 1987, percutaneous transluminal angioplasty (PTCA) was introduced in our center and PTCA was performed in 9 patients (6%). Restenosis of the dilated portions of the coronary artery was observed and PTCA was again performed in 2 of 9 patients (22%). All patients who received CABG or PTCA survived and have been free from angina or myocardial infarction. Non-fatal myocardial infarction occurred in 10 cases (5.6%) and fatal infarction occurred in one patient (0.6%).

Angina Pectoris↗
PubMed1989

[Prevention of spinal cord ischemia after cross-clamping of the thoracic aorta--monitoring of spinal cord perfusion pressure and somatosensory evoked potentials].

The pressure difference between the mean distal aortic pressure (MDAP) and the cerebrospinal fluid pressure (CSFP), defined as the spinal cord perfusion pressure (SCPP), as well as somatosensory evoked potentials (SEP) were monitored intraoperatively to detect and prevent intraoperative spinal cord ischemia in 24 patients who required cross-clamping of the descending thoracic aorta. A temporary axillo-femoral shunt, utilizing a 10 mm woven Dacron tube graft, was employed in 10 patients and partial cardiopulmonary bypass was employed in fourteen. Ischemic SEP changes were seen in six patients. Two patients, whose SCPPs were 32 and 35 mmHg, showed a complete loss of SEP and subsequently developed paraplegia. In the other four cases, increase of the MDAP and/or withdrawal of cerebrospinal fluid were performed to increase the SCPP to more than 60 mmHg when ischemic SEP changes occurred. The SEP gradually recovered in two of these cases. The ischemic SEP changes seen in one patient, who had the longest aortic cross-clamping time, (175 minutes) returned to normal immediately after unclamping. In another case, who had a thoracoabdominal aortic aneurysm, the intercostal arteries were reimplanted since the ischemic SEP changes did not revert. These four patients recovered without any neurological deficit. In the other 18 cases without ischemic SEP change, SCPP was kept at more than 40 mmHg during aortic cross-clamping. We conclude that the SCPP should be maintained at more than 40 mmHg during aortic occlusion, and increased to more than 60 mmHg when ischemic SEP changes occur, by increasing MDAP and/or withdrawing cerebrospinal fluid in order to prevent postoperative paraplegia.

Adult↗
PubMed1989

Some properties of bovine mitochondrial serine tRNA gene transcript synthesized with T7 RNA polymerase.

Bovine mitochondrial serine tRNA(AGY) gene transcript was synthesized in vitro with T7 RNA polymerase, and it was capable of being aminoacylated with mitochondrial serine tRNA synthetase. The melting profiles of the transcript was similar to those of native serine tRNA(AGY), suggesting that the higher-order structure of the transcript does not much differ from that of native serine tRNA(AGY). Several transcripts with base-substitution were also constructed and their aminoacylation capacity was investigated.

Animals↗
PubMed1989

Synthesis and properties of oligodeoxyribonucleotides containing N6-methoxyadenine.

Oligodeoxyribonuclotides containing N6-methoxyadenine (mo6A), a promutagenic base, were synthesized. The Tm values and thermodynamic parameters for double strand formation of d(CCTGGTAmo6ACAGGTCC) have been measured. The order of the base-pair stability was A-T greater than mo6A-C approximately equal to mo6A-T greater than A-C.

Adenine↗
PubMed1989

[Ultrasonography-guided cobalt-60 brachytherapy of malignant glioma].

Brachytherapy with cobalt-60 source is reported. In this method it is characterized that the source is inserted interstitially with remote control system by after-loading method via outer catheter (using tandem tube), which was established in the center of residual tumor, using ultrasonography guide with trepanation, or intraoperatively put within the dead space after tumor resection. Six cases of deep-seated and recurrent malignant glioma, were treated with this method. A total dose of 20 to 45 Gy (10 to 15 Gy/day for 2 to 3 days) was delivered to the target. Additionally conventional external irradiation was followed. The effect of cobalt-60 brachytherapy on such tumors were favorable especially for well-circumscribed glioma less than 3 cm on CT scan.

Adolescent↗
PubMed1989

[Specific cardiomyopathy caused by high dose cyclophosphamide immediately after bone marrow transplantation].

An 11-year-old girl with CML in chronic phase was treated with allogeneic bone marrow transplantation (BMT). She had had no episode of heart disease, and her chest roentgenogram and electrocardiogram were within normal ranges. She had no anthracycline, but 120 mg/kg (2.01 g/m2/d x 2 days) of cyclophosphamide (CY) for conditioning of BMT. She suffered from an acute heart failure on 14 days after BMT and died 2 days later. Autopsy revealed "specific heart muscular disease" with apparent degeneration and necrosis of heart muscle cells. More than 30 fatal cases of CY cardiotoxicity after BMT have been reported, and most patients developed acute heart failure within 10 days after CY dosing. Goldberg et al. reviewed 14 cases of CY cardiotoxicity, and considered more than 1.55 g/m2/day to be the critical doses for the onset of fatal cardiomyopathy. This case was considered to be first case in Japan. CY cardiomyopathy is an early fatal complication of BMT when CY used for conditioning. The dosing schedule may be considered.

Bone Marrow Transplantation↗
PubMed1989

[Intraoperative ST-T changes resembling myocardial ischemia due to accidental myocardial cooling].

During the mitral valve replacement on a 48-year-old male with mitral valve stenosis, ST-T changes (ST elevation and T inversion) suddenly appeared just before the start of cardiopulmonary bypass. Myocardial ischemia was suspected before we noticed the cardioplegic solution (about 10 degrees C) had been dripping on the surface of the right ventricle by mistake for about five minutes. After pouring warm saline over the myocardial surface, the EKG returned to normal within ten minutes. In this case, there appeared the elevation of the J point which is characteristic of profound hypothermia and is easily mistaken as myocardial ischemia because of ST segment elevation. It is very important to observe even a trivial intraoperative action which is not directly related with the operative procedure.

Accidents↗
PubMed1989

[Preservation of the isolated canine heart in 4 degrees C air with intermittent infusion of a cardioplegic solution].

The objective of this study is to determine whether intermittent infusions of cardioplegic solution has any effect on the isolated heart immersed in 4 degrees C saline. Further, in an attempt to prevent myocardial edema from developing during prolonged preservation, we stored the heart suspended in 4 degrees C air. In Experiment 1, 24 canine hearts were isolated after cardiac arrest induced by the infusion of 4 degrees C St. Thomas' Hospital Solution (STS). The isolated hearts were immediately immersed in 4 degrees C saline and divided into three groups (n = 8 in each group). The hearts were stored for 9 hours in 4 degrees C saline in Group 1 as well as in Group 2, however in the latter group intermittent infusions of STS were also given every 2 hours. In group 3, the hearts were suspended in 4 degrees C humidified air with intermittent infusions of STS every 2 hours. Intramyocardial pH showed a progressive fall in all 3 groups without significant difference in the rate of decrease among the groups (0.14/h in Group 1, 0.16/h in Group 2 and 0.13/h in Group 3, p less than 0.18). The ATP levels at 1 hour after excision were nearly the same in the three groups (about 25.9-26.3 micrograms/mg protein).(ABSTRACT TRUNCATED AT 250 WORDS)

Air↗
PubMed1989

[Clinical study on intracranial arachnoid cyst: with reference to the middle cranial fossa].

Thirty-two cases of congenital arachnoid cyst (AC), 26 cases of supratentorial, and 6 cases of infratentorial cyst are reported. They were encountered over a period of 9 years. The 26 supratentorial cysts consisted of 21 cases located in the middle fossa, 2 in the frontal, and 3 in the suprasellar. Patients' ages ranged from 7 months to 67 years (mean: 19.3 years), with a male to female ratio of 23:9. The most common symptoms were headache, epileptic seizure, and cranial enlargement. Based on observations between neuroradiological examinations including analysis of the cyst content, and operation, typical AC might be defined as "duplicated arachnoid and its splitting", and it may be said that "there is continuous existence of cerebral structure such as cortex and white matter lying adjacent to AC on MRI". Out of 32 cases, 15 received surgical treatment because of mass effect of AC itself, abnormal dynamics of the AC fluid, and/or increasing sign of ICP. 13 cases had resection of AC outer membrane with craniotomy, and the remaining two had cystoperitoneal shunt. One of the shunting cases complicated subdural hematoma. Surgical treatment was discussed and radical craniotomy rather than a shunt procedure was preferred. Prognosis of all cases was favorable and uneventful.

Adolescent↗
PubMed1989

[The prognosis and the surgical indications of DeBakey type III dissecting aortic aneurysm].

In order to determine the indications of operation for dissecting aortic aneurysm of DeBakey type III, therapeutic results obtained from 60 cases (11 with type IIIa and 49 with type IIIb) treated at our department during the 19-year period until the end of 1984 were analyzed as well as their distant prognosis. Since 12 cases (20%), who visited our department during the acute phase, were all abated to the subacute phase by hypotensive treatment, and since only one of the 12 cases died from pneumonia 5 weeks after the onset, it was thought that the operation during the acute phase is in most cases not necessary. We applied operation when there was a large false lumen, a regional protrusion, rupture or impending rupture. Out of the 60 cases, 25 (42%; 7 with type IIIa and 18 with type IIIb) underwent operation, and 3 of them (12%), including one ruptured case during the chronic phase, died due to the operation. Among cases with type IIIa, a non-operated case died of a related cause (rupture) during distant period, but none of operated cases died. Among discharged cases with type IIIb, 4 of 16 operated cases (25%) died of related causes during distant periods. This mortality did not differ from that of non-operated cases; namely, 8 of 30 non-operated cases died (27%). A 5-year survival rate was also identical between the non-operated and operated cases with type IIIb; namely, about 50% in the 2 groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

[Effects of cimetidine on plasma concentration of catecholamine and baroreflex control of heart rate in anesthetized humans].

To clarify the mechanism of cardiovascular depression by cimetidine, we studied the effects of intravenous cimetidine on the plasma catecholamine concentration and baroreflex control of heart rate in man before and during enflurane-nitrous oxide anesthesia. Baroreflex control of heart rate was assessed by raising the arterial pressure by phenylephrine. Before anesthesia, 200 mg cimetidine decreased plasma epinephrine concentration (E) from 135 +/- 48 (s.e.) pg.ml-1 at baseline to 91 +/- 35 pg.ml-1 5 min after administration, but there were no significant changes in the norepinephrine concentration (NE), slope of pressor response, systolic blood pressure (SBP) or heart rate (HR). In anesthetized patients, baseline values of E, NE and slope were all significantly decreased as compared to those without anesthesia. However, cimetidine administered during anesthesia decreased both SBP and HR, by 19 +/- 5 mmHg and 9 +/- 6 beats.min-1, respectively, without further decrease of plasma catecholamine or slope by cimetidine than those at baseline. We conclude that inhibition by cimetidine of cardiovascular system during anesthesia is not due to further depression of baroreflex or plasma catecholamine concentration.

Anesthesia, Inhalation↗
PubMed1989

[Malignant lymphoma of testis: a clinicopathologic study of twenty-six cases].

A clinicopathologic study was made on 26 patients with testicular lymphoma. Because they all presented scrotal swelling as an initial manifestation, they were thought to be affected with primary testicular lymphoma. The age at admission ranged from 39 to 87 years, with a median of 63 years. Stage of disease was I E in 8 patients, II E in 7, and III E in 8. Two- and five-year survival rates were 38% and 26%, respectively. The most common histological type was the diffuse large cell type, especially immunoblastic type. Immunohistochemistry revealed that almost all cases were B cell derived tumors. In our study, an obvious correlation between the histological type and the prognosis for patients could not be observed. However, the initial stage of the disease appeared to affect the outcome in patients with testicular lymphoma.

Adult↗
PubMed1988

Prognostic significance of mast cells in soft tissue sarcoma.

We counted the number of toluidine blue positive mast cells within and around the tumor in 44 patients with soft tissue sarcomas (STS). Irrespective of their histologic types, these cases were broadly divided into the following two groups: (1) low count (less than 20 mast cells/10 high-power fields [HPF]) and (2) high count (greater than or equal to 20 mast cells/10 HPF). The patients with a high mast cell count showed a significantly better 5-year survival rate than those with a low count (85.9% versus 30.5%; P less than 0.01). Five patients with distant metastases at first admission all belonged to the low count group. These results suggest that the number of mast cells within and around the tumor is a useful prognostic factor for STS.

Adolescent↗