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Biomedical subjects

T Ueda

Publications and source records attributed to T Ueda.

At least 1,441 records · Page 80Linked to original sources
PubMed1982

Quantitative observations on thermal and metabolic responses to cold of workers using vibrating tools.

Quantitative observations on thermal and metabolic responses of 32 patients exposed to moderate cold of vibration hazards due to using chain saw were performed. In this study, many cases showed trends of both in increase of metabolic rate and decrease of mean skin temperatures. The ratio of 60 min mean value of the increase of metabolic rate/decrease of mean skin temperature is 3.5 +/- 2.60. Twenty-two patients (68.8%) indicated the value larger than 3. There are many with markedly large increase in metabolic rate in those who affected Raynaud's phenomenon. It can be suggested that many of the patients with the vibration hazards indicate an decrease of the cold tolerance ot the moderate cold exposure.

Adult↗
PubMed1982

Neural and humoral factors influence gastric receptive relaxation in dogs.

To clarify the neural and humoral factors which control gastric receptive relaxation, the effects of various types of vagotomy or splanchnicotomy on receptive relaxation of the canine innervated corpus pouch were investigated. The influence of gastrin, histamine H1-receptor antagonist, and anti-histamine releasing agents on receptive relaxation were also examined. Selective proximal vagotomy or splanchnicotomy resulted in a slight disturbance in receptive relaxation. Truncal vagotomy produced a marked disturbance in receptive relaxation. Administration of tetragastrin potently inhibited receptive relaxation, however, recovery occurred by injecting a histamine H1-receptor antagonist. Increased serum gastrin induced by perfusion of the antrum with liver extract solution disturbed receptive relaxation and this response was inhibited by pretreatment with transamine, an inhibitor of histamine release from histamine secreting cells. These results indicate that receptive relaxation in the canine stomach is controlled not only by vagal and splanchnic nerves, but also by gastrin and histamine.

Animals↗
PubMed1982

Changes in intracellular pH accompanying chemoreception in the plasmodia of Physarum polycephalum.

A new method for measuring intracellular pH, employing the intrinsic fluorescent pigments of the plasmodia of the myxomycete Physarum polycephalum, was used to study the role of pH in chemotactic transduction in the plasmodia. The cell became acidified following stimulation with the attractants alanine, glucose, galactose and maltose when their concentrations exceeded the respective thresholds of chemoreception and taxis. The degree of cell acidification paralleled the relaxing tendency in tension generation. A non-metabolizable attractant, 2-deoxyglucose, also acidified the cell. However, the repellent salts NaCl, KCl and CaCl2 did not change the intracellular pH. Our results suggest that the effects of attractants are mediated by intracellular pH, while the effects of repellents are transduced by ATP as reported previously.

Adenosine Triphosphate↗
PubMed1982

Radioimmunoassay for metabolites of 9,3"-diacetylmidecamycin, a macrolide antibiotic.

A radioimmunoassay system has been developed for the measurement of two major metabolites of 9,3"-diacetylmidecamycin, Mb-6 and Mb-12. A radioimmunoassay for Mb-6 was performed by using anti-Mb-6 serum and a [125I]tyramined Mb-6 derivative as a radiolabeled antigen. The labeled antigen was prepared by the chloramine T method. The antiserum was obtained from a rabbit immunized with Mb-6 conjugated to bovine serum albumin. The obtained antiserum was cross-reactive with two other metabolites of 9,3"-diacetylmidecamycin, Mb-2 and Mb-12, in addition to Mb-6. This Mb-6 radioimmunoassay system could detect Mb-6 concentrations as low as 100 pg/ml of serum. The coefficients of variation were 4.5% (intra-assay) and 5.1% (inter-assay). A radioimmunoassay for Mb-12, using anti-midecamycin serum and a [125I]tyramined-Mb-12 derivative, has also been developed. The antiserum was cross-reactive only with Mb-12 among the 9,3"-diacetylmidecamycin metabolites. This Mb-12 radioimmunoassay system could detect Mb-12 concentrations as low as 2 ng/ml. The intra- and inter-assay variances were 5.9 and 5.8%, respectively.

Animals↗
PubMed1982

Ozone decontamination of bioclean rooms.

To establish a convenient method for decontaminating bioclean rooms, the effect of ozone at 80 mg/m3 for 72 h was compared with formaldehyde vaporization at an initial concentration of 150 mg/m3 with a gradual decrease to 20 mg/m3 during 72 h. Ozone was found to be inferior to formaldehyde in activity. When the bioclean room was decontaminated twice with ozone, the mean colony count per 10 cm2 was decreased to about the same level as when formaldehyde was used. Ozone had a strong caustic effect upon rubber materials. Despite these disadvantages, ozone decontamination was demonstrated to be superior to formaldehyde vaporization because of convenience, insignificant inhalation of the disinfectant by the hospital staff, and very rapid expulsion of the gas after ventilation. Because the disadvantages of ozone can be easily controlled, this study suggests that ozone decontamination is a promising method for maintaining bioclean rooms.

Bacillus subtilis↗
PubMed1982

Effects of carbon dioxide on serum biochemical patterns and on histopathological changes of organs in rats.

The effects of carbon dioxide on serum biochemical patterns and on histopathological changes of organs were studied in male Sprague-Dawley rats which were anesthetized with a mixture of 40% carbon dioxide and 60% oxygen for 3 hr. This level of carbon dioxide is sufficient to maintain rats at an anesthetized level. There were gradual decreased in respiration, body temperature, heart rate, blood pressure and blood pH. At the same time there were significant increases in organ weight (lungs and kidneys), and in exudate to thorax, hematocrit, and serum biochemical patterns (glucose, phosphorus, uric acid, blood urea nitrogen, glutamic pyruvic transaminase, glutamic oxaloacetic transaminase and alpha-hydroxybutyrate dehydrogenase). The weight of the liver, however, decreased slightly. There were minor abnormalities in both gross anatomy and histology (lungs, liver and kidneys). When the rats inhaled ordinary air, they awoke within a few minutes and recovered normal hematological level (pH 7.3, PaO2 120 mmHg and PaCO2 45 mmHg) within 24 hr.

Anesthesia↗
PubMed1982

Levels of CO2 in arterial blood of carp under carbon dioxide anesthesia.

The application of carbon dioxide anesthesia to fish has been studied in order to find a method of transport of live fish. In the continuation of this study, the levels of arterial PaO2, PaCO2 and pH were examined in carp anesthetized with carbon dioxide. In the initial stage of the anesthesia, both PaO2 and PaCO2 increased. In the following stage, PaCO2 gradually decreased. An increase or decrease in PaO2 seems to depend on the levels of PaCO2 during anesthesia. On the other hand, ECG (electrocardiogram) profiles of anesthetized carp indicate that a gradual increase in R-R interval is coupled with a gradual decline of the opercular rate.

Anesthetics↗
PubMed1982

[Chemotherapy of the malignancies from the viewpoint of pharmacology and biochemistry of cytosine arabinoside (ara-C) and its derivatives].

Ara-C should be converted to ara-CTP to inhibit DNA polymerase in the malignant cells but is rapidly inactivated to uracil arabinoside (ara-U) by cytidine deaminase in human tissue. Therefore, production as well as maintenance of ara-CTP in the cells is a function of both phosphorylation and deamination of ara-C, but is more dependent on the latter, because the deamination is several times superior to the former in terms of enzymatic activities. In chemotherapy with ara-C, the rate of the inactivation should be estimated for evaluating antitumor effect of the agent. Determination of serum or plasma deaminase activity can be a useful parameter of the inactivation. Attempts have been made to enhance the antitumor activity of ara-C by preventing deamination and a number of ara-C derivatives resistant to the deamination such as cyclocytidine, ara-C-5'-ester and acyl ara-C have been introduced. Cyclo-C gradually receives non-enzymatic hydrolysis to produce ara-C in neutral medium, which is useful for maintaining plasma ara-C level. Acyl ara-C such as behenoyl-ara-C (BHAC) is well incorporated into the cells and is highly distributed to lipophilic components such as membrane, microsome and mitochondria in the cells. The extremely gradual conversion of BHAC to ara-C in the cells is considered to be useful for maintaining effective intracellular concentration. A part of BHAC could be phosphorylated before deacylation. After intravenous administration of BHAC, the plasma drug concentrations are maintained significantly longer than those after the administration of the equivalent dose of ara-C. Therefore, BHAC is more resistant to the deamination than cyclo-C and the antitumor effect of the former is suspected to be milder but prolonged than that of ara-C or cyclo-C.

Ancitabine↗