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Biomedical subjects

T Videman

Publications and source records attributed to T Videman.

At least 55 records · Page 3Linked to original sources
PubMed1994

Digital assessment of MRI for lumbar disc desiccation. A comparison of digital versus subjective assessments and digital intensity profiles versus discogram and macroanatomic findings.

During magnetic resonance imaging, a vast amount of digital data on anatomic structures is translated into images, which are then assessed subjectively. The development of an objective, sensitive method to directly assess the digital data would have clear benefits, particularly for clinical research on disc degeneration. The study goals were to develop a method of digital assessment of disc desiccation and to compare digital signal intensity profiles with discographic patterns and macroanatomic findings. Proton density-weighted MRIs were obtained from 45 males (9-77 years) and digital analysis was done with a freely selectable region of interest facility. The adjacent cerebrospinal fluid (CSF) was used as a reference for disc signal-intensity scores, and the disc to CSF-intensity ratio provided "adjusted digital scores." The CSF-adjusted digital method yielded reproducible scores that correlated with the subjective assessments. However, the CSF-adjusted digital scores were more sensitive than the subjective assessments, identifying findings that otherwise were undetected in younger subjects. Additionally, 10 cadaveric spines were evaluated using MRI with T2 and proton density-weighted sequences, discography, and macroanatomic dissection. MRI disc-intensity profiles were determined along a midsagittal line drawn through the disc. The profile of the digital scores along this line was then compared with discograms and macroanatomic sections. In all cases of disc degeneration on discograms, changes were present in the intensity profile. Based on both the living subjects and the cadaveric specimens, the digital assessments and disc intensity profiles appear to demonstrate disc degeneration, particularly in early stages.

Adolescent↗
PubMed1994

Neck trouble in machine operating, dynamic physical work and sedentary work: a prospective study on occupational and individual risk factors.

A prospective study on the effects of occupational and individual factors on neck trouble was carried out among 1832 men representing static work with whole-body vibration (machine operators), dynamic physical work (construction carpenters) and sedentary work (office workers). Neck trouble and occupational and individual factors were inquired about via postal questionnaires in 1984 and 1987. Machine operating was associated with an increased risk to contract severe neck trouble, and machine operating and dynamic physical work were associated with persistently severe neck trouble. Other predictors for contracting severe neck trouble were age and current smoking. Physical exercise decreased the risk of persistently severe neck trouble. The results of our prospective study confirm the role of physical factors in neck trouble.

Adult↗
PubMed1993

Vital staining indicating cell migration towards the periphery in the growth plate. Studies of fibular heads in rabbits.

In 38 fibular heads of young rabbits the germinal layer of the growth plate was traversed perpendicularly to the axis of the bone with an injection needle. The resulting channel was packed with pieces of raw agar-agar carrying Nile blue sulfate dye. The rabbits were killed after 1-8 days. In frozen sections of the fibular heads, stained cells were scattered over the germinal layer; in 19 of the plates a row of distinctly stained cells reached from the periphery of the germinal layer to the borderline of the innermost corner of the ossification groove of Ranvier (1889). Our results strengthen the view that the cells forming the periosteal bone originate in the growth plate, with implications for the pathogenesis of diseases of the growing skeleton.

Animals↗
PubMed1991

A life-long prospective study on the role of psychosocial factors in neck-shoulder and low-back pain.

The predictive value of psychosocial factors in the development of neck--shoulder and low-back symptoms was investigated in a life-long follow-up study of 154 subjects. Measurements taken in adolescence, such as intelligence, alexithymia (low verbal productivity in projective personality tests), social confidence, hobbies, and the socioeconomic status of the family, showed no consistent associations with neck--shoulder or low-back symptoms in adulthood. Of the variables recorded in adulthood, weak mental resources for promoting health (poor sense of coherence) were consistently associated with neck--shoulder pain, whereas low fundamental education predicted low-back symptoms. The results suggest that psychosocial factors in childhood have a minor role as direct predictors of later symptoms.

Adult↗
PubMed1991

Prevalence of low back pain and other musculoskeletal symptoms and their association with work in Finnish reindeer herders.

The prevalence of musculoskeletal symptoms was determined in a population-based sample of 2720 male reindeer herders in Finland by postal questionnaires sent out in 1986 and 1988. Sixty per cent reported back pain, 32% sciatica, 51% neck-shoulder pain, and 49% pain, aching or tenderness in at least one joint during the past 12 months. The neck-shoulder and joint symptoms increased with the annual amount of reindeer herding work done in persons below 50 years of age. The association of back pain with the amount of work was weak, and no consistent association was found for sciatica. Neck-shoulder and joint symptoms were most frequently exacerbated by physically heavy work such as slaughtering the reindeer. It is suggested that self-reported neck-shoulder and joint symptoms are associated with reindeer herding, but that the association is partly biased due to selection of disease-prone older individuals for less demanding tasks.

Adolescent↗
PubMed1991

1991 Volvo Award in clinical sciences. Smoking and lumbar intervertebral disc degeneration: an MRI study of identical twins.

The primary objective of this study was to determine whether disc degeneration, as assessed through magnetic resonance imaging, is greater in smokers than in nonsmokers. To control for the maximum number of potentially confounding variables, pairs of identical twins highly discordant for cigarette smoking were selected as study subjects. Data analyses revealed 18% greater mean disc degeneration scores in the lumbar spines of smokers as compared with nonsmokers. The effect was present across the entire lumbar spine, implicating a mechanism acting systemically. This investigation demonstrates the efficiency of using carefully selected controls in studying conditions of multifactorial etiology, such as disc degeneration.

Awards and Prizes↗
PubMed1990

1990 Volvo Award in clinical sciences. Lumbar spinal pathology in cadaveric material in relation to history of back pain, occupation, and physical loading.

The occurrence of symmetric disc degeneration, anular ruptures, end-plate defects, vertebral body osteophytosis, and facet joint osteoarthrosis was examined radiographically and osteologically in 86 male cadavers for whom occupational, physical loading, and back pain histories were obtained from the men's families. History of back pain and the parameters of spinal pathology were related to the highest and lowest degrees of physical loading. In multivariate analyses, history of back injury was related to the occurrence of symmetric disc degeneration, anular ruptures, and vertebral osteophytosis. Symmetric disc degeneration was associated with sedentary work, and vertebral osteophytosis was related to heavy work. History of back pain was related to occupational physical loading after control for the effects of the other covariates. The results indicate that the least pathology stemmed from moderate or mixed physical loading, but the least back pain was associated with sedentary work.

Adult↗
PubMed1989

Patient-handling skill, back injuries, and back pain. An intervention study in nursing.

The aim of this intervention was to evaluate the effect of training on patient-handling skills and prospectively to assess the effect of skill on subsequent back pain and back injuries in nursing. Of a total of 255 nurses, 199 were assessed for their skill in patient-handling. One-half (control group) received traditional training in patient-handling, and the other half (trained group) received a curriculum of instruction totaling 40 hours. The skills of both groups were assessed on graduation. The control group was rated as less competent in patient-handling. Nurses in both groups were questioned about the prevalence of back pain and incidence of back injuries in the first year after graduation. In multiple regression analysis, the major risk indicators for back injuries were poor patient-handling skill, low numbers of repetitions in the sit-up test, and high work-load scores. High score on the hysteria scale of Middlesex Hospital Questionnaire was a risk indicator for all kinds of back pain. Though back pain was independent of patient-handling skill, those rated as "bad" or "poor" had more back injuries (24%) than those who had been rated as "good" or "excellent" (2%) (P less than 0.001), but the difference between the trained and control groups was not statistically significant. It was concluded that back injuries may be prevented by the teaching of patient-handling skills.

Back Injuries↗
PubMed1989

Evaluation of cervical disc degeneration with ultralow field MRI and discography. An experimental study on cadavers.

The purpose of this study was to test the value of low-field magnetic resonance imaging (MRI) and discography in visualizing disc degeneration of the cervical spine. Plain roentgenograms, MR images, discograms, and macroanatomic appearance of the cervical spines of ten cadavers were compared. At levels C4-5-C7-T1, general disc degeneration seen in discography correlated well with macroanatomy (weighted kappa (Kw) = 0.77). The nuclear shape in MRI showed a weak correlation with macroanatomy (Kw = 0.31) and general disc degeneration in discography (Kw = 0.32), whereas nuclear intensity in MRI underestimated such changes. Magnetic resonance imaging showed posterior extension of the nucleus in most cases where moderate or severe leaking was seen in discography. The latter phenomenon represents an increase to our information on structural changes not available by any other noninvasive and nonirradiative method of examination.

Adult↗
PubMed1989

Regeneration of the growth plate.

The occurrence of growth plate regeneration has been doubted. However, in 5 different series of experiments reported between 1950 and 1986 regeneration of injured parts of growth plates in long bones of rabbits and pigs could be demonstrated. The 1st series implied partial X-ray injury of growth plates in rabbits aged 3-6 weeks. The 2nd series implied autotransplantation of the head of the fibula in rabbits aged 10-21 days. The 3rd, 4th and 5th series implied transplantation of autologous fat grafts into provoked defects of growth plates in rabbits and pigs. The findings show that regeneration of a growth plate occurs when a part of it is injured in such a manner that a bone bridge is not formed between the epiphysis and the metaphysis. Regeneration of a plate is much faster in relation to the growth in length of the bone in the rabbit than in the pig. The 1st and 2nd series suggest that regeneration takes place by interstitial proliferation of cells from the germinal layer of the uninjured parts of the plate. Signs of partial regeneration of growth plates have been seen in radiographs after operation for partial closure of growth plates in children.

Adipose Tissue↗
PubMed1989

Genetic and environmental factors in sciatica. Evidence from a nationwide panel of 9365 adult twin pairs.

The relative roles of genetic and environmental factors in sciatica were studied in the nationwide Finnish twin panel consisting of 9365 adult pairs of the same gender. Morbidity was analysed from two sources of data: the life-long cumulative incidence was measured by a postal questionnaire, and the rate of hospital admission during a 14-year period was measured by record-linkage of the twin panel and the nationwide hospital registry. Altogether 2220 individuals reported sciatica diagnosed by a doctor and 304 were admitted to hospital with a diagnosis of sciatica. The proportion of concordant pairs (calculated from affected pairs) was 17.7% for monozygotic and 12.0% for dizygotic pairs in the life-long cumulative incidence of reported sciatica, and correspondingly 4.6% and 1.9% for those admitted to hospital (a 14-year period) because of sciatica. The estimated heritability was 20.8% for those with reported sciatica and 10.6% for those admitted to hospital. The results show that environmental factors account for more than 80% of the etiology of sciatica, and more than 90% in the case of patients admitted to the hospital. Genetic factors, however, were relatively more significant in individuals under 40.

Adult↗
PubMed1989

Low-back pain and occupation. A cross-sectional questionnaire study of men in machine operating, dynamic physical work, and sedentary work.

The frequency of sciatic pain, lumbago, and nonspecific low-back pain (LBP) and factors related to these symptoms were determined among men occupied in machine operating (541 longshoremen and 311 earthmover operators), dynamic physical work (696 carpenters), and sedentary work (674 municipal office workers). Sciatic pain was more common among machine operators and carpenters than among office workers, and also more frequent among machine operators than among carpenters. The occupational differences were considerably smaller with regard to lumbago and nonspecific LBP. In multivariate analysis, occupation, age, reported back accidents, and postural load showed significant independent effects on the occurrence of sciatic pain. Allowing for other risk indicators, the relative risk was 1.3 contrasting machine operators with both office workers and carpenters, but carpenters had no excess risk as compared with office workers.

Absenteeism↗
PubMed1988

Bone ingrowth into porous calcium phosphate ceramics: influence of pulsing electromagnetic field.

The effect of a pulsing electromagnetic field (PEMF) on bone ingrowth into porous hydroxyapatite (HA) and porous tricalcium phosphate (TCP) implanted in rabbit tibiae was studied. To quantitate the biological response, a recently developed method of surface measurement using a scanning electron microscope was used. The morphometrical findings in the HA pores demonstrated a significantly greater amount of bone and thicker bone trabeculae in the PEMF group as compared with the nonpulsed control group at 3 to 4 weeks postimplantation. No significant differences for these parameters were found in the TCP pores. Histologically, more bone and wider bone trabeculae were observed in the HA implants for the PEMF-treated animals at the early time periods when compared with those of the control animals. Alternatively, the histological findings of the TCP implants were similar between these two groups. These histological results tended to correlate with the morphometrical data. Together, these results suggest that accelerated bone formation and bone maturation occurred in response to PEMF in the HA pores but was without effect in the TCP pores. This stimulatory effect is most significant after 3-4 weeks of PEMF stimulation.

Animals↗
PubMed1988

Disc deterioration in low-back syndromes. A prospective, multi-center CT/discography study.

Disc deterioration and pain provocation in different low-back pain syndromes was studied using computed tomography (CT) discography. Data were prospectively collected for 300 patients (816 discs). Patients were classified by their pre-discography diagnosis of disc herniation (DH), degenerated disc (DD), lumbar syndrome (LS), lumbar radicular syndrome (LRS), or other. The CT/discograms were classified by discographic pain response, the amount of degeneration and annular disruption. Eighty-two percent of DH patients, 80% of DD, 56% of LS, and 59% of LRS patients had both positive discographic pain provocation and moderate or severe disc deterioration. The study indicates that intradiscal pathology plays a major role in nonspecific low-back pain syndromes.

Back Pain↗
PubMed1988

Neck and shoulder symptoms among men in machine operating, dynamic physical work and sedentary work.

Data on the occurrence of neck and shoulder symptoms and some qualities of work and leisure-time activities were gathered with a postal questionnaire sent to 1,174 machine operators, 1,045 carpenters, and 1,013 office workers. They were all men in the age range of 25-49 years. The response rate was 67-76%. The lifetime cumulative incidence of neck and shoulder symptoms was 81% for the machine operators, 73% for the carpenters, and 57% for the office workers. About half of the two groups of manual workers and 24% of the office workers had had symptoms during the last 7 d. Pain in the arms was indicated by 14-17% of the manual workers and 4% of the office workers. Symptoms during more than 30 d within the last 12 months were also more common among the manual workers than among the office workers. Within the manual worker groups, the machine operators had more symptoms than the carpenters. In a multivariate logistic regression analysis occupation, working in twisted or bent postures, age, draft, and job satisfaction proved to be significant risk indicators for neck and shoulder symptoms.

Adult↗
PubMed1987

Experimental study on the repair of full thickness articular cartilage defects: effects of varying periods of continuous passive motion, cage activity, and immobilization.

In order to clarify the dose/response characteristics of continuous passive motion (CPM), the repair response of full thickness articular cartilage defects was studied in a rabbit model. The following combinations of CPM and immobilization (Imm) were utilized: CPM, 24 h/day; CPM, 8 h/day and Imm, 16 h/day; CPM, 2 h/day and Imm 22 h/day; Imm 24 h/day; and normal cage activity. These regimens were used only in the initial week and then all rabbits were permitted to move freely in their cages, except for a sixth Imm-CPM group that was kept immobilized in the initial week and then CPM 24 h/day for another week. The CPM 24 h/day and the CPM 8 h/day groups (groups 1 and 4, respectively) showed better repair than the other groups, i.e., better surface congruity, larger positive Safranin-O staining area, and greater number of chondrocytes in the repair tissue. The CPM 2 h/day group (group 3), however, showed only slightly better repair than the Imm group (group 4). The CPM following immobilization was not effective to overcome the harmful effect of immobilization. We conclude that in the present model, CPM for 8 or 24 h/day is effective for adequate cartilage repair even with some component of immobilization. Its application should be at least 8 h/day. On the contrary, if CPM is delayed for a week following immobilization, the effect of CPM on cartilage will be reduced.

Animals↗