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Biomedical subjects

T Wegmann

Publications and source records attributed to T Wegmann.

At least 19 recordsLinked to original sources
PubMed1989

Regulation of constitutive and lymphokine-induced Ia expression by murine alpha-fetoprotein.

alpha-Fetoprotein (AFP) has been shown to suppress a variety of immune responses in vitro. The immunosuppressive properties of AFP can be partly attributed to the ability of this protein to decrease the cell surface expression of Ia antigens on macrophages. The experiments described in this report define more precisely the regulatory effects of AFP on Ia expression. Using the "dendritic-like" cell line P388 AD2 and bone marrow-derived macrophages we have shown that AFP can suppress the constitutive expression of cell surface Ia antigens. This decrease is detectable on the cell surface 24 hr after the addition of AFP. In further experiments we also examined the effect of AFP on lymphokine-induced Ia expression. Our results show that AFP has no suppressive influence on the inductive phase of lymphokine-induced Ia antigen expression but can decrease elevated levels of Ia antigen subsequent to their induction.

Animals↗
PubMed1986

[Etiology of atypical pneumonias. A serological study on 1494 patients].

In a retrospective study the serological results from 1494 patients with community-acquired pneumonia were evaluated. An infectious etiology was found in about 40% of the cases. The majority of pneumonias was caused by Mycoplasma pneumoniae and by influenza virus type A, whereas Legionella pneumophila was the fifth most frequent pathogen. In the second part of the study, 13 hospitalized patients with community-acquired pneumonia were investigated by the whole panel of routinely used microbial methods. The etiological agent was found serologically in 3 cases and in one case by cultivation. These results suggest that the determination of serum antibodies against pathogens is frequently more useful than is generally assumed, although the yield of positive results is dependent on the epidemiological situation. The detection of elevated complement-fixing titers or specific IgM antibodies often leads to diagnosis from the first serum examined.

Adolescent↗
PubMed1984

[Granulomatous cytomegalovirus hepatitis].

Four primarily healthy patients with granulomatous hepatitis during acute cytomegalovirus infection are described. Granulomatous hepatitis associated with cytomegalovirus infection has been described previously in only 7 patients. As the authors have observed 4 such cases within a period of one year, this disease pattern may occur more frequently than was formerly assumed.

Acute Disease↗
PubMed1984

[Antimycotic chemotherapy in weakened resistance].

Antifungal chemotherapy in weakened resistance is restricted to the following three substances: amphotericin B, 5-fluorocytosine and the azo dyes. The paper only discusses the therapy of indigenous iatrogenic fungal infections due to mycelial fungi (molds) and yeasts. The pathogenesis must be investigated in every case, since a healthy individual does not contract such a fungal infection. Prophylaxis would be more important than treatment of such complications. At the end of the paper, the therapy is summarized in a table. It is clearly seen from the table that the optimal modern therapy of systemic mycoses is a combination of 5-fluorocytosine in a normal dosage and amphotericin B at reduced dosage.

Amphotericin B↗
PubMed1979

[South American blastomycosis (paracoccidioidomycosis) in Switzerland. Clinical course and morphological findings in a case following long-term therapy].

The clinical course and morphological findings are reported of visceral paracoccidioidomycosis or South American blastomycosis with lung involvement in a 47-year-old male after specific antimycotic treatment for 11 years. The patient had been infected during a stay in São Paulo, Brazil, from 1950 to 1954. The diagnosis was established in 1959 after his return to St. Gall, Switzerland, in tissue from buccal mucosa and cervical lymph node biopsy and in fungus cultures. The patient was treated with Fungizone (amphotericin B) and with the sulfonamide Fanasil. He died in 1970 from acute right heart failure. Autopsy revealed multiple encapsulated mycotic foci in both lungs, together with healed foci and pulmonary fibrosis. Histological examination showed a large amount of Paracoccidioides brasiliensis in the mycotic foci, but cultural proof was no longer possible. In the buccal mucosa and lymph nodes, only fungus-free scars were observed. There are only a few effective antimycotic agents. With a thorough knowledge of their side effects and dosage modalities, it is possible to achieve highly satisfactory results.

Brazil↗
PubMed1979

[Candida coxitis (author's transl)].

Following drug-induced agranulocytosis and antibiotic and steroid treatment, sepsis due to candida albicans together with bilateral fungal coxitis developed in a 41-year-old female patient. Satisfactory eradication of the inflammatory process was achieved with combined treatment with amphotericin B and 5-fluorocytosine, so that mobilisation was possible after surgical fitting of bilateral total endoprothesis.

Adult↗