[Rhesus prevention and course following amniocentesis in early pregnancy].
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Biomedical subjects
Publications and source records attributed to U Herrmann.
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The authors present a study of 631 breast-cyst punctures. Apart from statistics concerning the occurrence of these cysts, a simple and economical therapy using puncture and subsequent insufflation with air is described. The cysts were diagnosed with the aid of ultrasonics, pneumocystography and cytology. In 90% of the cases complications such as haematomas and infections occurred, and recurrence of the cysts was observed in 7.1% of the patients. Puncture of cysts means that the women do not have to undergo unnecessary operations and subsequent cosmetic corrections. The treatment carries no operative or anaesthetic risks. Intra- and para-cystic carcinoma is easily recognized and patients are not burdened with radiation treatment.
After feeding a ration rich in protein and subsequent N-free feeding of 6 served gilts provided with intravenous permanent catheters and bladder catheters, the change of the urea concentration in the blood (UCB) and the N-excretion in urine were investigated. UCB increased during the first few hours after the intake of the protein containing ration, reached its maximum after 4 hours an 38 minutes and then decreased continuously. The maximum of the hourly N-excretion in urine was ascertained after 9 hours and 46 minutes. 60 hours after the protein intake UCB as well as N-excretion in urine reached an average minimal level of 10.5 mg urea/100 ml blood serum resp. 0.57 g N/hour. In a further experiment with four served gilts the close correlation between UCB and N-excretion in urine was confirmed after feeding 4 different protein levels. Blood sampling at the moment of feeding resulted in lower UCB values and smaller dispersion (d% = 5.9) in comparison to blood sampling 6 hours after feeding (d% = 12.2). The relation between UCB and N-excretion in urine however was lower at the moment of feed intake (r = 0.949 in contrast to r = 0.987). Under consideration of the maximum UCB, blood sampling for the determination of the UCB for the purpose of characterising N-excretion in urine and protein utilisation between 4 and 5 hours after feeding is recommended.
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In 4 double-blind, randomized, stratified, parallel group studies, single oral doses of fluproquazone (75 to 200 mg), a new nonsteroidal anti-inflammatory analgesic, were compared with aspirin (1,000 mg) and placebo in a total of 672 hospitalized patients with moderate or severe pain following episiotomy or other surgical interventions. A dose-dependent effect of fluproquazone which was highly significantly superior to placebo and which resembled the effect of aspirin with respect to onset, degree, and duration was noted in all studies. Fluproquazone, 100 to 150 mg, was found to be approximately equiactive to 1,000 mg of aspirin and better tolerated.
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Evidence for immunologic processes taking part in the pathogenesis of what until now has been called the "essential" form of EPH gestosis is cited. The name of immunogestosis (IG) is introduced. The data of this preliminary study suggest that regular "inoculation" of the female genital tract with allogeneic spermatozoal histocompatibility antigens reduces the incidence of IG. Information about preconceptional sexual habits and contraceptive measures was obtained from 83 selected primigravid patients. Twenty-eight women had mild to moderate IG (Group B);55 did not (Group A). Women in Group B had had less contact with spermatozoa of partners than did women in Group A. Oral contraceptive consumption was less in Group B than in Group A. Women in Group B were younger than women in Group A. All these differences were statistically significant. A new immunoetiologic hypothesis referring to IG, as well as the theoretic and clinical implications arising from it, are discussed. This hypothesis is based on the assumption that spermatozoal histocompatibility antigens can either induce immunologic tolerance or be responsible for the phenomenon of immunologic enhancement in the maternal immunosystem. As the fetus inherits paternal histocompatibility antigens, it is concluded that pre-existing tolerance (or enhancement) exerts an IG-preventive function in a subsequent pregnancy.
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Report on further experience in the treatment of functional sterility in 102 patients with clomiphene. Changes compatible with ovulation were present in 71,6%. Pregnancy was obtained in 34,0%. The best results were obtained in patients with secondary amenorrhoea and luteal corpus insufficiency. Adding HCG on 10th and 12th day of treatment had no substantial effect on increasing either the ovulatory rate or the pregnancy rate.
Smears from the uterine cervix have been evaluated for neoplastic changes on the basis of descriptive terms. The material was obtained by a single gynecologist using a standardized sampling technique and the results were compared with the respective histological diagnoses. Material which was found to be unsuitable for technical reasons was excluded from this study. A 98.7% agreement between cytological and histological findings was noted. Discrepancies between cytological and histological findings were essentially due to differing dysplastic changes in the deeper layers of the surface epithelium and the cervical glands, which were not sampled by the smears on the surface layer. In a few cases the discrepancies could not be explained but they disappeared after several years of observation. The practitioner should be acquainted with the nomenclature used by cytologists. In his turn, the cytologist should be familiar with the pathological anatomy of the organ in question.
The evaluation of smears of the uterine cervix on the basis of descriptive terms requires the practitioner to be acquainted with the nomenclature used by cytologists. A theoretical scheme is provided which correlates the diagnostic features encountered with their respective clinical implications.
Prove of a little hormonactive adrenal Adenoma in the ovary by katheterisation of vena femoralis and selective determination of Plasma-Testosteron in various regions of abdominal veins. Localisation of the tumor by routine diagnostic measures, even by Laparoscopy, had been impossible.