[Pericarditis, pleurisy, pulmonary coin lesions: extra-articular manifestations of rheumatoid arthritis?].
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Biomedical subjects
Publications and source records attributed to U Mödder.
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The ranking of MRT was evaluated retrospectively in 37 patients with clinically confirmed malignant neoplasms of the head and neck. The results were compared with the clinical and endoscopic findings and with computed tomographic scans (CT). MR consistently showed superior soft tissue definition and extent of disease compared with CT. However, the sensitivity of both methods was comparably high. With the exception of tumours of the floor of the mouth and the anterior third of tongue the use of paramagnetic contrast material improved image quality compared with T2-sequences. MRT was superior to CT in imaging the post-treatment head and neck. Even here, contrast enhanced T1-images improved contrast between recurrent tumour and adjacent soft tissues, although in some cases false positive diagnosis was caused by postradiation oedema and inflammatory changes.
The features of barium meal, ultrasonography and CT in 18 patients with proven primary gastric lymphoma were analyzed retrospectively. Only barium meal could reveal highly suspicious features in 16 cases, whereas ultrasonography and CT showed a non specific wall thickening. Although single signs in a barium meal are non-specific, the combination of clubbing of mucosal folds, atypical ulcerations and extensive mural infiltration is highly suspicious of lymphomatous involvement. A negative barium meal, ultrasonography and/or CT result does not exclude gastric lymphoma.
Using optimal equipment and an adequate examination technique, renal venous DSA for renal artery stenosis is today a diagnostic procedure in 98% of cases. Its sensitivity equals 85%, its specificity reaches 95%. Comparing accuracies and positive predictive values, renal venous DSA is superior to radionuclide studies. Pre-selection of patients with captopril as a pharmacologic test is expected to increase the predictive values of renal venous DSA and to confirm the hemodynamic significance of an angiographically detected renal artery stenosis.
In 713 patients 749 catheter-arteriographies of aortic-arch and cerebral vessels were performed using non-ionic contrast media. The patients were examined either with DSA or conventional film techniques. In 80 examinations of 76 patients complications or side-effects were noted, which resolved completely within one hour in 69 cases, showed a duration up to 7 days in 6 cases, and persisted longer than 7 days in 5 patients. Neurological complications were seen in 6.4% of the studies. There was no death. Patients, who received anti-hypertensive drugs before or during angiography and patients with a pathological angiogram had a significantly higher complication-rate. The rising number of patients with atherosclerotic cerebrovascular disease showed an unfavorable effect upon the overall complication-rate. The use of a non-ionic contrast medium did not drastically lower the rate of neurological complications.
The diagnostic value of magnetic resonance imaging is examined in relation to computed tomography on the basis of 66 patients, who had pathological processes in the midfacial and nasopharyngeal space. The high power of contrast resolution in imaging soft tissue masses and the direct multiplanar capability of magnetic resonance offer advantages over computed tomography in respect of space occupying lesions in the median and lower parts of the craniofacial skull. Lymph nodes of more than 1 cm. in diameter were detected by both modalities. A disadvantage is the poorer detectability of tumour conditioned bone destruction at the base of the skull. In such cases, computed tomography remains the method of choice.
Pre-operative computed tomograms were obtained in 52 patients with histologically confirmed peripheral bronchial carcinomas and possible involvement of the pleura and thoracic wall was analysed. The results were compared with the operative and histological findings. Thickening of the pleura and of the sub-pleural fat line was observed in 24 cases. Amongst these patients there was only one case with histologically confirmed pleural infiltration. In 17 patients the sub-pleural fat line was obliterated, or could not be defined. Amongst these, 11 showed tumour extension to the pleura or soft tissues of the chest wall. It is concluded that the most suspicions sign of pleural tumour extension is absence of the sub-pleural fat line. The more frequently observed pleural thickening cannot be considered as a reliable sign for pleural involvement.
Based on ten patients suffering from internal jugular vein thrombosis the use of modern radiological procedures is discussed. The clinical examination should be followed by high-resolution ultrasonography. In most cases ultrasonography is able to reveal the correct diagnosis. Complementary computed tomography is recommended, if ultrasonography cannot establish the diagnosis of jugular vein thrombosis or if the thrombosis involves the v. cava superior, respectively the mediastinum. Retrograde catheter venography of the internal jugular vein is unnecessary, phlebography of one or both upper extremities should be completed, if the internal jugular vein thrombosis continues to the v. subclavia or v. cava superior and surgical intervention is discussed.
32 patients with lesions of the facial skeleton, the neck and the parapharyngeal space were examined with NMR (Nuclear Magnetic Response). The results are compared with CT scanning. NMR offers high soft tissue contrast. Multiplanar imaging easily distinguishes tumours and lymph nodes from the cervical vessels and muscles. In contrast CT, is more useful for the imaging of destruction of the facial skeleton and the skull base.
In some patients the transverse process is palpable as a solid immobile knot in the angle of the mandible and is sometimes interpreted as an enlarged cervical gland or as a tumour of the parotid gland. The difficulties of differential diagnosis are illustrated by case reports. The possibilities of examination (full-size radiogram, tomogram, computer tomogram) are shown. The results of cephalometric measurements concerning the size of the atlas and its relation to the base of the skull are also described.
The radiological appearance of mostly broad-based polyps in the rectosigmoid was studied in 35 patients. In all patients the diagnosis was histologically confirmed after surgical treatment. Conclusions on the histological tumour status could not be drawn either from surface structure, broadness of base and retraction of base, or from the base/height ratio. Stenosing growth, however, was seen relatively more often with carcinomas than with benign lesions. The discovery and identification of five carcinomas having a size of up to 2 cm illustrates the need for complete removal and histological processing of even seemingly negligible residues of polypous processes in the rectosigmoid.
The opacification of the maxillary sinuses following Caldwell-Luc procedure seen with plain films depends to a great deal on bony changes. Based on 60 cases the advantages of the computed tomography especially in high-resolution mode are described in comparison with plain films. CT-scans clearly demonstrate the bony changes following Caldwell-Luc procedure, they show the size of the air-filled antrum and reveal inflammation of fibrous soft tissue within the sinus maxillares. Computed tomography facilitates differential diagnosis with regard to other pathological changes of the antrum. If radiological examination following Caldwell-Luc procedure is indicated, CT represents the method of choice.
The CT findings in 120 patients following trauma to the orbits, and in 60 patients with iatrogenic abnormalities, have been analysed. CT has been found to be extremely useful in the diagnosis of trauma and postoperative changes by its ability to demonstrate fractures, foreign bodies, haematomas, abscesses, soft tissue displacement or perforation of orbital structures, as well as showing prosthetic material.
The typical CT visualisation of silicone implants and prostheses after ophthalmological operations to the eye and orbit are described. Changes following surgery or trauma, such as haemorrhage, inflammation or abscess, are discussed and the difficulties in differential diagnosis are dealt with.
Masses in the head of the pancreas area may be caused by neoplastic, inflammatory and a variety of other processes originating within the pancreas or in adjacent structures and organs. CT following intravenous bolus injection of the contrast agent and oral staining of the small bowel allows the precise anatomic localization of the lesion and helps to evaluate its dignity and pathology. Nevertheless, frequently the final can be established only at open surgery and by histopathologic examination of the resected specimen.
Resection is the treatment of choice in organ-limited pancreatic cancer. In locally or regional, not completely resectable pancreatic cancer other therapeutic modalities are called upon: external beam radiotherapy results in relief of pain in 50% and average survival rate of about 10 months according to recent series in the literature. Loco-regional tumor control can be improved by intraoperative electrons or interstitial implantation of radioactive sources. - The combination of monochemotherapy (5-fluorouracil) and 40 Gy radiotherapy is well tolerated and tends to prolong survival also if given after curative resection.
A retrospective study of 57 patients was made to assess the potential of magnetic resonance imaging (MRI) for demonstrating malignant lymph node disease in comparison with other imaging modalities. All patients were suspected of having lymphadenopathy in cervical, mediastinal or abdominal lymph nodes. MRI was superior in differentiating tumor involved lymph nodes from surrounding structures. On the other hand this advantage was curtailed by the spatial resolution, poorer than CT. In comparison with ultrasound MRI is the better reproducible modality and is independent of patients' constitution. Additionally MRI gives a completer overview, including retrocrural and pelvic lymph nodes. In conclusion the useful routine of ultrasonography first, completed by CT will not be changed by MRI. MRI as an additional modality is only indicated to differentiate enlarged lymph nodes from vascular structures or muscles.
With the advent of ultrasonography and computed tomography in the diagnosis of nodal and/or extranodal manifestation of non-Hodgkin's lymphoma (NHL) lymphomatous involvement of sites other than lymph nodes is seen with increasing frequency. - Review of patients with newly diagnosed or recurrent disease revealed 93 unusual extranodal sites below the diaphragm in peritoneal or retroperitoneal structures or organs. - Concomitant retroperitoneal and/or mesenteric adenopathy was common; extranodal involvement was rarely the only site of initial or recurrent lymphoma.