Biomedical subjects

U Sjögren

Publications and source records attributed to U Sjögren.

49 records · Page 3Linked to original sources

PubMed1976

Different composition and mitotic activity of the haemopoietic tissue in bone marrow, spleen and liver in chronic myeloid leukaemia.

Aspirates from bone marrow, spleen and liver were analyzed in 15 untreated patients with chronic myeloid leukaemia (CML). The proportion of erythroblasts was higher in the spleen and liver than in the bone marrow. An increased frequency of basophilic leucocytes was recorded in the extramedullary sites compared to the bone marrow. In the liver aspirates a considerable admixture of lymphocytes was found. The mitotic indices of the granulopoietic and erythropoietic precursor cells were lower in the spleen and liver than in the bone marrow. The results indicate that the composition and proliferative activity of the haemopoietic tissue differ in bone marrow and extramedullary sites in CML. The discrepancies may be due to differences in the microenvironment for the haemopoietic cells or to a selective accumulation of cells with a low mitotic activity in extramedullary sites. Since the final blastic transformation of CML may originate outside the bone marrow, further studies of the extramedullary haemopoietic tissue may be worthwhile.

Bone Marrow↗

PubMed1976

Low mitotic activity in eosinophilic leukaemia.

The mitotic indices of the eosinophilic precursors in the bone marrow of 3 untreated patients with eosinophilic leukaemia were found to be significantly lower than those of 11 patients with reactive eosinophilia and those of 15 healthy controls. The same differences were found in the neutrophilic precursors and in the myeloblasts indicating leukaemic involvement of both the eosinophilic and neutrophilic cell lines. Mitotic countings therefore seem to be of diagnostic significance in this rare disease.

Aged↗

PubMed1976

Erythroblastic islands and extra-medullary erythropoiesis in chronic myeloid leukaemia.

Aspirates from bone marrow, spleen and liver were morphologically analysed in 15 untreated patients wich chronic myeloid leukaemia. Megaloblastic changes of the erythroblasts were found to be more common in the spleen and liver than in the bone marrow. A significant increase of 'erythroblastic islands', i.e. erythroblasts in contact with reticulum cells, were recorded in the leukaemia patients compared to 15 healthy controls. It is suggested that the presence of such formations may indicate an increased death rate of defective erythroblasts followed by phagocytosis into reticuloendothelial cells.

Bone Marrow↗

PubMed1976

Amoeboid movement configuration and mitotic indices of lymphoid cells from children with acute lymphoblastic leukaemia.

Bone marrow smears from 21 untreated patients with ALL have been morphologically analysed. There was a positive correlation between the percentages of lymphoid cells with amoeboid movement configuration (AMC) and the mitotic indices. A high proportion of cells with AMC seems to indicate a more favourable prognosis in spite of differences in subsequent treatment. It is suggested that studies of the incidence of AMC may serve as a prognostic tool in ALL.

Adolescent↗

PubMed1975

Erythroblastic islands and ineffective erythropoiesis in acute myeloid leukaemia.

The erythropoietic part of the bone marrow has been morphologically analysed in 34 untreated, anaemic patients with acute myeloid leukaemia and in 17 healthy controls. In the patients with leukaemia the percentage of basophilic erythroblasts was abnormally high and elevated mitotic indices of the erythroblasts were recorded. The accumulation of basophilic erythroblasts and a high frequency of megaloblastoid changes of the cells may indicate ineffective erythropoiesis. A threefold increase of "erythroblastic islands", i.e. erythroblasts in contact with reticulum cells were recorded in the patients with erythroleukaemia and a twofold increase in the patients with acute myeloid leukaemia. The erythroblastic islands may indicate phagocytosis of defective erythroblasts and an intramedullary haemolysis may thus contribute to the development of anaemia.

Adolescent↗

PubMed1975

Megaloblastic changes and chromosome abnormalities of erythropoietic cells in acute myeloid leukaemia.

Using Giemsa banding technique, the bone marrow chromosomes were studied in 9 patients with acute myeloid leukaemia (AML). Four patients had 100% normal diploid cells and 5 had 100% abnormal cells: 28-92% of the mitoses were found in erythroid cells. The percentage of erythroblasts with megaloblastoid changes was abnormally high. It was not increased in the cases with chromosomal abnormalities. These findings indicate that chromosomal aberrations are not prerequisites for the development of megaloblasts in AML. Furthermore, abnormalities in the DNA synthesis bringing about the megaloblastoid changes may occur without influencing karyotype.

Acute Disease↗

PubMed1974