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Biomedical subjects

U Töllner

Publications and source records attributed to U Töllner.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Fulminant autoimmune cold-type hemolysis with marked elevation of monothermic cold agglutinins. Successful therapy with membrane plasmapheresis].

Autoimmune hemolytic anemia associated with cold autoantibodies is rare in infancy. In a 7 months old infant with severe hemolysis, a hemoglobin of 5.9 g/dl and a cold agglutinin titer of 1:8000, even the transfusion of warmed, packed red cells (37 degrees C) lead to hemolysis. Hemoglobin fell to 2.8 g/dl despite prevention of exposure to cold, parenteral steroids and immunoglobulins. Cold agglutinin titer fell to 1:8 after plasma separation. Subsequent transfusion did not lead to hemolysis and permanent remission was achieved.

Agglutinins↗
PubMed1990

[Facial injuries caused by dog bites in childhood. Clinical staging, therapy and prevention].

Dog bite injuries are a frequent cause of facial injuries in childhood. Between 1986 and 1990 we treated 16 children with facial dog bite injuries. Based on these experiences we suggest a clinical classification, corresponding therapeutic rules and prophylactic possibilities, summarized according to the literature. It is our aim to establish guidelines for the physician concerned with the therapy of these injuries, and advice to involved families.

Animals↗
PubMed1989

[Acute, non-traumatic paraplegia syndromes in children].

Acute, non-traumatic paraplegia is a very rare condition in childhood. Because of this the correct diagnosis is not recognized in time. We want to call attention to this illness by reporting on four patients we treated between the years 1984 and 1986. We put together and analyzed the literature on this disorder for the first time, and established guide lines-first, to recognize those causes of the disorder which by all means have to be treated in time, and second, how to proceed further diagnostically.

Adolescent↗
PubMed1988

[Prenatal diagnosis of sialidosis, a defect of the lysosomal enzyme neuraminidase].

Sialidosis, a lysosomal storage disease, ranged as oligosaccharidosis, is a genetic enzyme defect with a significantly restricted survival rate of the child concerned. After the preceded birth of a child who died of sialidosis, we succeeded in the correct prenatal exclusion of the disease with the prediction of a heterocygotic carrier status by biochemical analysis of cultivated amnion cells. The growth of these cells as well as the postnatal examined fibroblasts was significantly reduced. The possibility of the prenatal diagnosis of sialidosis allowed a pregnancy following the birth of a diseased child.

Adult↗
PubMed1986

Effect of stress on calcium homeostasis in sheep.

The acute effect of stress on the plasma and cerebrospinal fluid (CSF) immunoreactive parathyroid hormone (PTH) response was studied in 6 merino sheep. Stress was exerted by weak periodical electric square waves (PESW). In addition, the effect of intravenous injection of adrenaline was studied. Under stress conditions (PESW or adrenaline injection), plasma PTH increased up to 30% and up to 50%, respectively. Weak periodical electric square waves of 3-4 mA decreased CSF PTH concentrations by up to 50%. The effect of adrenaline injection on the CSF PTH was not significant. Total calcium and magnesium in plasma and CSF did not change. Our results showed that the effect of stress on the CSF PTH is opposite to the effect on plasma PTH, and suggest that both, PESW and adrenaline, affected PTH in plasma and CSF by a Ca-independent mechanism.

Animals↗
PubMed1984

Immunoreactive parathyroid hormone, calcium, and magnesium in human cerebrospinal fluid.

Parathyroid hormone (PTH) was measured radioimmunologically in simultaneous plasma and cerebrospinal fluid (CSF) samples obtained from 72 patients aged 20 to 80 years without endocrine or psychiatric diseases and from 2 patients aged 40 and 70 years with secondary hyperparathyroidism due to renal insufficiency. They underwent routine diagnostic lumbar puncture because of suspected prolapse of a disc. Total calcium (Ca) and magnesium (Mg) were also determined in these samples by complexometry . The following findings were obtained (ng/ml, median, range in brackets): Plasma PTH 1.7 (0.7-6.6); CSF PTH 0.8 (0.5-2.3), respectively. No correlation was found between PTH concentrations in plasma and CSF in all 74 samples. The Ca concentrations in plasma, with a median of 2.3 mmol/l (2.1-2.6) were significantly higher than the Ca concentrations in CSF (median 1.1 mmol/l, range 0.4-1.3). The correlation between PTH and calcium levels in CSF was only weak (r = 0.284 P less than 0.05). The Mg levels in CSF (median 1.1 mmol/l, range 0.7-1.6) were higher than Mg concentrations in plasma (median 0.9 mmol/l, range 0.6-1.1). No correlation was found between PTH and Mg in CSF. Our study demonstrated that in man PTH is a normal constituent of CSF.

Adult↗
PubMed1984

[Comparative studies on general anesthesia versus peridural anesthesia in primary cesarean section].

In a prospective interdisciplinary study involving the departments of gynaecology, anaesthetics and paediatrics, the influence on both the mother and neonate of general as opposed to epidural anaesthesia was compared in 47 planned caesarean sections. Neither maternal or foetal risk factors were present in these cases, and the cardiotocogram was always normal before the anaesthetic was applied. Methods. Systolic and diastolic blood pressure were carefully monitored. Under an identical infusion regime the following parameters were estimated in maternal blood: blood gas and acid-base status, blood sugar, lactate, beta-hydroxybutyric acid, ACTH and cortisol. These same parameters were also estimated in cord blood taken at delivery. The Apgar score at 1, 5 and 10 minutes, and a complete paediatric assessment including neurostatus at 15 minutes, 24 hours and 7 days of age were used to assess neonatal status. Some of the women given a general anaesthetic initially had marked increases in blood pressure and pulse, while about a third of the epidural cases showed a blood pressure fall despite positioning in the left lateral position in order to prevent the aorto-caval syndrome. An increase in lactate, ACTH and cortisol was found in both groups up to the time of delivery, when the ACTH level of the general anaesthetic group was significantly higher. Acid-base and PCO2 values were not markedly influenced by either of the techniques used, but the maternal capillary PO2 levels were very much higher in the general anaesthetic group. The neonates born under general anaesthetic had a lower 1 min Apgar score, as a result of the relatively long induction-delivery time, of on average 17 min. The 5 and 10 min Apgar scores and the neurophysiological development of the babies revealed no differences between the two groups.

Adult↗
PubMed1984

[Acute epiglottitis in childhood].

Report on 44 cases of acute epiglottitis in childhood. All of these had typical local findings and there was positive proof of bacterial growth. The incidence and occurrence of symptoms and principal signs is discussed. The high incidence of wrong diagnoses is remarkable. 4 out of 44 patients died before reaching a hospital or due to hypoxia. A concept is presented covering preclinical diagnostics and therapy, appropriate care during transport in the first-aid ambulance, and clinical treatment in the hospital.

Acute Disease↗
PubMed1983

[Hairy nasopharyngeal polyp as a respiratory emergency].

Respiratory distress and a total airway obstruction in an newborn was caused by a mobile tumour in the pharynx. Urgently it had to be fixed with holding suture under traction. Surgical resection revealed a bipartial hairy tumour based on the lateral pharyngeal side of the soft palate. The histologic examination showed: fat tissue, cornified epidermis and sebaceous glands, but no further signs of teratoma. Further complications as Pneumothorax and necrotising entercolitis could be managed.

Emergencies↗
PubMed1981

Heptacarpo-octatarso-dactyly combined with multiple malformation.

A case of heptacarpo-octatarso-dactyly combined with cheilo-gnatho-palato-schisis, hypertelorism, macroglossia, complex malformations of heart and great vessels, horse-shoe-kidney, micro-penis, and penis palmatus is described. To our knowledge, this syndrome has not yet been described in the literature. Some of the features of the case reported overlap with syndromes such as Grauhan syndrome and Meckel syndrome.

Abnormalities, Multiple↗
PubMed1981

[Haemolysis as initial sign of Clostridium perfringens septicaemia in newborn (author's transl)].

Cases of Clostridium perfringens, septicaemia are subject to a very gloomy prognosis in adults. This applies likewise to the rare cases reported in paediatric literature. The present report describes the fatal case of a newborn with Clostridium perfringens septicaemia. The principal sign was a severe haemolysis which failed to respond to blood exchange transfusions and antibiotic treatment. The characteristic changes of colour of the skin usually observed in septicaemia of newborn had probably been masked for some time by the reddish discolouration caused by the haemolysis, so that diagnosis was established at a late stage only.

Anemia, Hemolytic↗
PubMed1981

[Prevention of iatrogenic colon perforations in the newborn and infant (author's transl)].

Gastrointestinal perforations in infancy mainly occur during the newborn period. Iatrogenic perforations of the rectosigmoid colon are frequent. The mortality rate is high. A method to prevent this serious complication of diagnostic and therapeutic enemas is described. A conical olive is introduced into the anus. Direct perforation of the rectal wall is impossible. The ever-present danger of indirect perforation by increased intraluminal pressure is reduced.

Colon↗