[Immunohematologic changes in patients subjected to surgery under conditions of artificial blood circulation using washed erythrocytes].
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Biomedical subjects
Publications and source records attributed to V A Dmitrieva.
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An examination of 54 patients with congenital heart disease has established an increased production of immunoglobulins, M class in particular, enhanced formation of circulating immune complexes, insufficient phagocytic activity of neutrophils, decreased content of T-lymphocytes. Patients with bacterial endocarditis were found to have more pronounced changes in immune reactivity. Reliable differences were found when comparing indices of nitroblue tetrazolium test in patients with an infectious process and without it.
The authors examined 29 patients with aorto-arteritis of unspecific origin of different duration and variants of affections of the major vessels. The patients were divided into groups with active and inactive course of the inflammatory process. The changes of immunological values and the phagocytosis data were more marked in the group with the active phase of the disease. These changes correlated with the data on unspecific inflammation and the clinical picture. Twenty-two patients were treated by hemosorption and immunocorrective measures. The fibrinogen concentration reduced, the ESR was normalized, and C-reactive protein became negative. The concentration of circulating immune complex and immunoglobulins diminished, the phagocytosis values became close to normal. It is concluded that hemosorption is an effective method of correction of immunological disorders in unspecific aorto-arteritis, both as an independent therapeutic method and as a measure of preoperative management.
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