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Biomedical subjects

V A Gerasin

Publications and source records attributed to V A Gerasin.

At least 19 recordsLinked to original sources

[The fiber bronchoscopic evaluation of the bronchial inflammatory changes and hyperreactivity in bronchial asthma patients].

Bronchofibroscopic bronchial examination detected inflammation-induced changes in the bronchi in the form of mucosal thickening (edema), small masses of the sputum and occasional hyperemia in the majority of the examinees with bronchial asthma. In combination with bronchoalveolar lavage, bronchofibroscopy provides diagnosis of bronchial hyperreactivity basing on determination of segmentary bronchial stenosis in response to salt solution instillation. The degree of this stenosis can evidence the degree of hyperreactivity of the bronchi. Bronchofibroscopic signs of bronchial hyperreactivity appear more distinctly in asthma aggravations, in severe run of the disease, in pronounced inflammation.

Adolescent

[Endoscopic laser surgery of the trachea].

Bronchoscopic laser operative interventions with the use of yttrium- aluminum -garnet laser were carried out in 36 patients with various pathological structures of the trachea. Laser endosurgery was applied as radical and palliative types of therapy. Endoscopic laser interventions make it possible to remove completely benign and carcinoid tumors, correct some types of cicatricial stenoses, restore continuity of the trachea, and remove respiratory insufficiency in inoperable malignant neoplasms with exophytic growth.

Adolescent

Bronchoscopic laser photocoagulation of superficial cancer of the bronchi.

Multifocal squamous cell carcinoma in the bronchus of the anterior segment of the right lung and in the subsegmental bronchus of the posterior subsegment of the left upper lobe was diagnosed in a 61-year-old man. The right-sided upper lobectomy followed by Nd:YAG laser photocoagulation of the superficial cancer in the left side resulted in total eradication of the tumor. Subsequent follow-up examinations for three years have revealed no relapse of tumor growth.

Bronchial Neoplasms

[The detection of mast cells in the bronchoalveolar contents in lung diseases].

Detection of mast cells in the liquid of bronchoalveolar lavage is made with the aid of staining with alcyane blue after fixation of the cytologic preparations in vapors of 40% formalin. In healthy persons, the content of mast cells in bronchial lavage constitutes 0.4-0.1%, in the majority of patients with bronchial asthma, 0.06-3.3%, and in some patients with sarcoidosis, 0.04-1.07%.

Adolescent

[Assessment of mucociliary clearance using the radioaerosol method in chronic lung diseases].

The radioaerosol technique with the use of radioalbumin from the TSK-5 kit and of an ultrasonic inhaler makes it possible to determine primarily the mucociliary clearance of the central parts of the tracheobronchial tree. In patients without any pathology of the respiratory organs, the clearance of the inhaled radiopharmaceutical constitutes 45.5 +/- 9.5 percent for an hour. In patients with pulmonary pathology, the characteristics of the mucociliary clearance vary from dramatically decreased to normal ones depending on the disease pattern, exacerbation phase or remission.

Adolescent

Endobronchial electrosurgery.

Endobronchial electrosurgery (EBES) with the aid of a fiberoptic bronchoscope and a diathermic snare has been performed in 14 patients with tracheal and bronchial tumors (eight with benign, one with carcinoid, and five with malignant tumors). Total eradication has been achieved in the nine patients with benign and carcinoid tumors. In some patients, EBES was supplemented with surgical removal with the biopsy forceps or laser coagulation. Electroexcision of the endobronchial portion of the tumor helped to clear the respiratory airways in three of the five patients with malignant tumors. Emergent EBES was performed in two patients with acute respiratory failure and massive hemorrhage caused by adenocystic and thyroid cancer of the trachea.

Adult

[Diagnostic bronchoalveolar lavage in assessing the efficacy of the treatment of idiopathic fibrosing alveolitis].

A study of the results of repeated diagnostic bronchoalveolar lavage in 27 patients with idiopathic fibrosing alveolitis (IFA) has shown that the investigation of cellular composition of the bronchoalveolar content (BAC) made it possible to specify IFA activity and its therapy-related change. Normalization or a decrease below 6% of the neutrophil content in BAC was typical of achieving low activity and remission of disease. A relatively high count of neutrophils in BAC (over 10%) during therapy was observed in preserved significant IFA activity resistant to drug therapy.

Adult

Endobronchial surgery of trachea and bronchi.

Bronchoscopic operative interventions were performed in 57 patients. We used photocoagulation with neodym-YAG-Laser, electrosurgery with fibroscopic diathermic snare and mechanical removal of endobronchial neoplasms. The most effective method was the laser photocoagulation, which permits removal of benign tumors, carcinoids, massive cicatrical tracheal stenosis and noninvasive bronchial cancer, help in restoring the lumen of main airways in case of nonoperable malignant tumors.

Adolescent