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Biomedical subjects

V A Trufakin

Publications and source records attributed to V A Trufakin.

At least 37 records · Page 2Linked to original sources
PubMed1999

[Chronobiology of immune system].

The biological rhythmological programme of the immune system is a constituent of the body's common biological rhythmological programme. Its pattern seems to be genetically determined and reflects the functional status of the system. The chronobiological mechanisms responsible for the regulation of immune functions lie in the presence of certain phasic interrelations between the biological rhythms of the synthesis and production of regulatory agents on the one hand, and those of the receptor system and metabolic potential of immunocompetent cells on the other. The facts given in the paper may be a basis for a chronobiological approach to better understanding the mechanisms of the physiology and pathology of the immune system. The medical significance of study of the structural and temporal pattern of the immune system consists in the development of new techniques for diagnosis, prognosis, therapy, and assessment of risk factors in immunopathological conditions.

Animals↗
PubMed1999

[Changes in various parameters of the mouse immune status subjected to chronic social conflict].

Recurrent experience of a social confrontation was shown to increase the per cent of cleavage nucleus neutrophiles in both mice-participants, activation of the lymphocyte dehydrogenase, and reduction of number of the CDA+ and CD8+ T-lymphocytes. Dynamic character of changes in the metabolism parameters and the number of lymphocytes is obviously dependent on duration of the confrontations in mice.

Animals↗
PubMed1998

Russian Academy of Medical Sciences (RAMS), Siberian Branch, activity in solving the medical problems of Russian Circumpolar regions.

RAMS, Siberian Branch, has been actively participating for the last 25 years in elaboration and realization of numerous scientifically applied programs aimed at improving diagnosis, treatment, and prophylaxis of the most widespread diseases among the Native and newcoming populations of the Russian Far North (Taimyr, Yakutia, and Chukotka). The medical researchers of different RAMS, Siberian Branch, institutes, based on long-term investigations, have obtained a number of largely new data on etiology, pathogenesis, and epidemiology of cardiovascular, infectious, and cancer disease; diabetes; alcohol addiction; trauma; etc., and have developed practical recommendations for public health institutions on improvement of people's health.

Academies and Institutes↗
PubMed1994

[Immunological mechanisms of the formation of ecologically-induced pathology].

The paper provides the results of examining about 3,000 industrial workers exposed to various xenobiotics. Various phases of immune responses were noted in 40-60% of persons with nonspecific chronic pulmonary, gastrointestinal, gynecological diseases at remission. 10-20% of the industrial workers under study were diagnosed as having secondary immunodeficiency whose criteria were the presence of one of clinical syndromes, a sharply significant reduction in immunoglobulins, normal levels of circulating immune complexes and normal values of the lymphocytic enzymes alpha-glycerophosphate dehydrogenase, succinate dehydrogenase, lactate dehydrogenase. The stimulation of the immune system in clinically healthy individuals who have a service length of 3 year or more should be regarded as development of an immune response to a xenobiotic or its metabolites.

Adult↗
PubMed1991

[The immune system and its regulatory role in the processes of proliferation and differentiation in the body].

The reported and original research data on immune regulation of cellular proliferation and differentiation in diverse tissues are summarized. Such regulative function is considered to be the expression of the proposed role of the immune system in the realization of genetic information at the integral bodily level. It is postulated that in addition to the information flow: DNA--RNA--protein (in each cell), another information flow may exist: the central organs of the lymphoid system--lymphocytes migrating to different organs and tissues--organs and tissues characterized by specific organ, tissue and differentiation antigens.

Cell Count↗
PubMed1990

[Kinetics of cell population of the jejunal mucosal epithelium in mice after administration of syngeneic lymphocytes].

By means of the radioautographic method the state of cellular restoration of the gastric epithelium has been estimated after administration of syngenic lymphocytes to mice. Under conditions of physiological regeneration T-lymphocytes are able to inhibit proliferation of the epithelial cells and to limit the size of the proliferation zone in crypts. The inhibition degree of the proliferative activity depends on the doze of the T-cells administered. In order to demonstrate their activity, T-cells do not need DNA and RNA synthesis de novo. At the same time, protein synthesis is necessary; it occurs on long-living mRNA lymphocytes. The T-lymphocyte action is reversible at the tissue, but not at the cellular level. The mechanism of decreasing cell reproduction under effect of T-lymphocytes is described. In the process of lymphoid regulation of the cellular restoration in the intestinal epithelium changes in the size of the proliferative pool play the main role.

Animals↗
PubMed1989

[The effect of T-lymphocytes on epithelial proliferation of the jejunal mucosa in thymectomized mice].

Following 1.5 month period after thymectomy of adult mice the crypt 3H-thymidine labelling index is decreased and the proliferative zone is reduced. Analysis of labeled cell distributions in the crypt revealed that thymectomy resulted in the initiation of enterocyte entering a maturation phase in the site shifted to the crypt base. Syngeneic T-lymphocytes injected intravenously to thymectomized mice increased the labeling index, but exerted no effect on the size of proliferative zone. The proliferative changes described were not due to changes in the number of divisions of rapidly proliferating enterocytes. The role of T-lymphocytes in modulation of intestinal epithelium proliferation and steady state maintenance is discussed.

Animals↗
PubMed1986

[Interrelation of diurnal rhythms of recirculation of lymphocytes and their synthesis of cAMP].

The correlative analysis of diurnal rhythms of cell number and adenylate cyclase cellular activity was performed in the thymus, spleen and peripheral blood of Swiss mice, intact or thymectomized at the age of 3 months. The existence of somehow synchronized diurnal rhythms of cAMP exchange and cell recirculation was found in the peripheral lymphocyte pool and in the thymus. Diurnal rhythm of cAMP synthesis in peripheral lymphocytes was regulated by the thymus. Thymectomy led to desynchronization of recirculating processes and cyclic nucleotide metabolism in immunocompetent cells.

Animals↗
PubMed1986

[Effect of syngeneic thymocytes on the proliferation of the small intestine epithelium in mice].

The effect of syngeneic thymocytes on the proliferative compartment of the small intestinal epithelium was studied in CBA mice. In mice that intravenously received thymus cells, the proliferative enterocyte activity was depressed, the proliferative zone reduced and the maturation zone enlarged. The data obtained indicate that medullary thymocytes are responsible for this effect. The regulatory role of the immune system with regard to cell proliferation is discussed.

Animals↗