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Biomedical subjects

V A Tsinzerling

Publications and source records attributed to V A Tsinzerling.

At least 19 recordsLinked to original sources
PubMed2005

[Infective endocarditis: the features of its clinical course and the prognosis].

The paper covers an investigation of 150 patients with infective endocarditis (IE), including 100 patients (aged 18 to 30 years old) with intravenous drug abuse as the main risk factor. This subgroup is characterized by an acute clinical course of IE, with tricuspid valve disorder in most cases and septic pulmonary embolism relapse in 72% of cases. Heart failure, multiple cardiac valvular disorder and focal lung destruction were found to be the main factors of unfavorable outcome. A relation between the size of vegetation on the heart valves and the mortality rate was established. At the same time, secondary immunodeficiency due to HIV-infection had no significant effect on the mortality rate in the group of drug addicts. More frequent cases of heart failure with systemic circulation embolism lead to higher hospital mortality in the group of patients with a subacute clinical course of IE. In elderly patients other concomitant pathology resulted in late IE detection and a high mortality rate.

Adolescent↗
PubMed2000

[Relationship between chronic viral hepatitis and hepatocellular carcinoma].

Recent years have seen a correlation between the rise in morbidity and lethality from chronic viral hepatitis and that of hepatocellular carcinoma. Present-day methods of hepatotropic viruses (HBV and HCV) identification point to a growing role of chronic viral hepatitis in etiology of cirrhosis which gives rise to hepatocellular cancers. A study of 49 cases based on sectional material established hepatocellular carcinoma development in smoldering chronic viral hepatitis caused by B or C virus or their combination. An immunohistochemical investigation (29) identified differences in hepatitis B and C virus antigen expression in tumor and adjacent hepatic tissue.

Carcinoma, Hepatocellular↗
PubMed1996

[Cardiac involvement in diphtheria today in adults].

Postmortem morphological examination of 102 cases with diphtheria who had died on the disease day 1-120 was performed. All the dead patients were adults. Dystrophic-necrotic processes in cardiac conduction and intramural nervous systems, in contractile myocardium developing on the disease day 1-8 were found. The severity and extent of these processes depended on toxic and hypoxic factors resultant from obturation or ventilation respiratory failure. Myocarditis progression undergoes 2 stages: early, exudative (beginning on the disease day 3) and late, productive (beginning on the disease day 9). The disease eventuated in myocardiosclerosis starting after 28-day course. Morphologically, diphtheritic cardiac lesion differed from cardiac damage caused by other acute infections.

Adult↗
PubMed1995

[Clinical and laboratory characteristics of rotavirus infection in adults].

The paper provides clinical and laboratory characteristics of 21 patients aged 20-80 years who had rotavirus infection, including 52% of 51-80-year-old inpatients. Recovery was observed in 15 cases, 6 patients died. The paper also characterizes the clinical course of rotavirus infection in the hospital setting and presents autopsy findings of the 6 decreased patients. The manifestations specific for rotavirus infection were identified to be involvement of serous and mucosal membranes predominantly of the small intestine, frequent development of serous peritonitis, as well as generalization of an infectious process afflicting the gallbladder, liver, heart, lung, and kidney.

Adult↗
PubMed1993

[Morphology of recent meningococcal infections in children].

An analysis of 108 cases of children's death which occurred in 1981-1991 from hypertoxic meningococcal infection (MI) in St. Petersburg is presented. Serogroup B meningococcus as a causative agent was found in 44% of the cases. The role in the thanatogenesis of inflammatory and immune reactions, viral-bacterial associations was shown on the basis of detailed study of 47 cases. Hemorrhagic adrenal necrosis was diagnosed in 94.7% of the cases. Two clinicomorphological variants of the disease are distinguished: 1) variant with a moderate hemorrhagic eruption without pronounced kidney lesion, 2) variant with an abundant confluent rash and pronounced kidney lesions and choroid plexus immune lesions.

Adrenal Glands↗
PubMed1993

[Morphologic aspects of hemostasis disturbances in meningococcemia in children].

21 children who died from meningococcemia were studied. Shock disturbances of the microcirculation and thrombocytic part of hemostasis prevailed within first hours of the disease in the form of adrenal hemorrhages and brain edema as immediate cause of death. With an increase of the disease duration, aggregational thrombocytopenia, generalized microthrombosis, coagulopathy, fibrinolysis activation resulted in massive hemorrhages in a number of organs and tissues and manifested in the syndrome of polyorganic failure. No significant differences were found depending upon treatment.

Adrenal Gland Diseases↗
PubMed1993

[Experimental model of generalized herpetic infection in newborns].

Generalized herpetic infection (GI) with a predominant involvement of the brain, eye, liver and spleen, in which cell rhexis and hyperchromatosis and large necrotic foci were observed, has been experimentally reproduced in newborn rabbits. Administration of herpes simplex virus at the dose of 5LD50 resulted in the suppression of immune reactions and animal death 4-5 days later. Dose of 2LD50 resulted in the immune response in the lymphoid organs, but the signs of the disease disappeared 5 days after the injection of the virus. The hypothesis on the existence of several clinico-morphological variants of GI is postulated.

Animals↗
PubMed1993

[Cytomegaloviral infection in autopsy material using molecular biologic methods].

The results of polymerization chain reaction (PCR) and morphological study are compared. The presence of cytomegalovirus (CMV) DNA in the organs of dead children is demonstrated by PCR in 13 of 16 cases. In 3 of 13 cases structural changes typical for CMV infection were absent; slight symptoms of the damage produced by DNA-virus were present in 4 cases. The results indicate that there exist variants of CMV infection with a minimum manifestation of the infectious process. The presence of mutations in the CMV genome was revealed in 6 cases.

Autopsy↗
PubMed1991

[Klebsiella pneumonia today].

Analysis of incidence and morphology of Klebsiella pneumonia nowadays in the adults (10 observations), children (5 observations) and newborns (23 observations) is presented. The pneumonias account for 11.3% of total number of lobar pneumonias in the adults dying in 1979-1989. Klebsiella infection represent 16.1% of total number of autopsies a year according to the pediatric infection pathology department. Etiological role of Klebsiella is established in 21.5% of total number of autopsies of newborns for 1985-1988, pneumonia being 61% of total Klebsiella infections. Klebsiella pneumonias in the adults correspond in principle to the Friedländer's pneumonia studied in detail by V.D. Zinserling (1891-1960) and his students. Generalized forms of, as a rule, hospital Klebsiellosis with most grave lung damage, unknown up to now, are frequently observed in children. Klebsiellosis was combined practically in all cases both in the adults and children with other bacterial, viral and fungal infections. The degree of clinico-morphological manifestations may considerably vary.

Adult↗
PubMed1990

[The interrelationship of cytomegalovirus infection and immunodeficiencies].

The results of examination of 87 children who died from a generalized cytomegalovirus infection in Elista (66 cases) in 1984-1985, 1988-89, and in Leningrad (21 cases) in 1988-89 are available. In the Elista material a considerable increase (from 21 to 66%) of severe forms of accidental transformation of thymus is observed in the second period comparing to the first one. The causes of a serious worsening of the immunological background remain unclear. Cytomegaly represented 3.85% of all dead children in the pathology department of the First Children Hospital of Leningrad. There was sialadenitis in 4 cases and generalized infection with involvement of the lungs, liver, kidneys, brain, myocardium, pancreas, adrenals in 17 cases. Cytomegaly was diagnosed in 3 of 5 cases of primary immunodeficiency. Diagnosis in some cases was confirmed by the DNA cytomegalovirus detection by means of PCR reaction.

Child↗
PubMed1990

[The combination of hepatitis with different etiologies and developmental defects of the biliary tract].

Anamnestic, clinical and morphological data presented concern 34 children with malformations of excretory bile ducts (15 with atresia of intra- and extrahepatic bile ducts, 12 with atresia of distal regions of the external bile ducts, 7 with cystic dilatation of ductus choledochus). Analysis of operation material revealed the presence of hepatitis in 30 cases including 16 cases with giant cell hepatitis associated with malformations. Intrauterine hepatitis B was found in 24 cases, herpetic hepatitis in 2 cases and Mycoplasma-related hepatitis in 3 cases (one of them in combination with hepatitis B). The etiology was not established in 2 cases. Accompanying bacterial infection was in 6 observations.

Bile Ducts↗
PubMed1987

[Meningoencephalitis and generalized infections in children (clinico-morphological comparisons)].

The results of morphological investigation of 254 children who have died in Leningrad from the currently most topical viral, bacterial, and mycoplasmic neuroinfections are analyzed. The authors describe the changes related to the properties of the causative agent, the nature of infection (intrauterine or postnatal), and to the duration of the disease. Clinical findings are collated with the literature data. Different meningoencephalitides show considerable polymorphism of the clinical symptomatology and structural alterations. The principles of the reliable etiological diagnosis of neuroinfections are validated. The authors propose that the terms 'meningoencephalitis' and 'generalized infection with cerebral involvement' be used differentially.

Bacterial Infections↗
PubMed1987

[Herpetic lesions of the nervous system in children].

A total of 125 children with acute infections were examined for herpetic infection, using the conventional viroserological techniques, as well as new methods for rapid diagnosis: the immune competition and immune hemadsorption tests. Thorough pathomorphological examination was carried out in lethal cases. The diagnosis was confirmed in 24 cases. The latter were divided into three groups: (1) herpetic encephalitides (n = 15), serous meningitis (n = 1), and meningomyeloradiculoneuritis (n = 1); (2) involvement of the nervous system as a result of exacerbation of latent herpetic infection in suppurative meningitides (n = 5); (3) persistence of the herpes virus in other neuroinfections (n = 2). Excerpts from the case reports, and electroencephalographic and pathomorphological findings are presented.

Acute Disease↗
PubMed1987

[Pathological anatomy and problems of the pathogenesis of pneumococcal meningoencephalitis in children].

The analysis of morphological, clinical and bacteriological data on 31 deceased children with pneumococcal meningoencephalitis is presented. The lesions observed at early and late stages of the disease are characterized in detail and the tendency of pneumococcal meningoencephalitis to a chronic course in the presence of the viable pathogen is shown. The majority of pneumococcal meningoencephalitides were proved to develop primarily, and in their pathogenesis significant role is played by the lesions of hematoencephalic barrier caused by respiratory viruses. High lethality and frequency of severe residual changes in the children with pneumococcal meningoencephalitis are due to early lesions of choroid plexuses and brain matter. In the experiment on 18 rabbits with their suboccipital challenge with 3 different pneumococcal strains, the influence of the biological properties of the pathogen on the clinical and morphological features of the illness is shown.

Acute Disease↗
PubMed1986

[Pathological anatomy of herpetic brain lesions in infants].

Results of morphological examination of brain herpetic lesions in 29 children are presented. There were 5 observations of necrotic meningo-encephalitis, among children with generalized intrauterine herpes, less severe changes were found in other cases. 14 children suffered from acute necrotic meningo-encephalitis developed after birth. Changes typical for herpes are described in neural, glial and ependymal cells; the type of response in different forms of lesions is shown. The correlation between the gangliosides content in the brain tissue and the surviving neural cells and a specific increase of ganglioside GD1b fraction in brain tissue were demonstrated by biochemical and morphological studies.

Acute Disease↗