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V A Zuev

Publications and source records attributed to V A Zuev.

At least 55 records · Page 3Linked to original sources
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[The role of suppressor cells in congenital influenza infection in mice].

Young mice with congenital influenza infection have lower immune responsiveness of lymphocytes to nonspecific mitogens and influenza virus antigens. Lymphocytes of such animals inhibit proliferation of normal lymphoid cells activated with concanavalin A and immune lymphocytes activated with influenza virus antigens. It is assumed that in congenital influenza infection one of the possible mechanisms of immunosuppression in mice is the activation of suppressor T-cells.

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[Induction by an inactivated influenza virus of congenital pathology and pregnancy pathology in mice].

Intravenous inoculation of pregnant mice with inactivated (noninfectious) influenza virus reduces by one-third their fertility owing to the death of the fetuses. Among the progeny of such females, there are specimens with signs of progressive pathology clinically similar to that which develops in the progeny born to the females intranasally inoculated during pregnancy with a live (infectious) influenza virus. The frequency of such pathology depends both on the virus strain and on genetic characteristics of mice. The role of influenza virus surface structures in the development of pathology of pregnancy and pathology in the progeny is discussed.

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[Slow influenzal infection developing in the progeny of mice as a result of infection of the females during pregnancy].

Transplacental transmission of influenza virus from female mice infected during pregnancy may be detected as early as one day after virus inoculation, and the concentration of the infectious virus in fetal tissues is proportional to the infective dose. The intrauterine infection of fetuses leads to the development in a portion of progeny of slow influenza infection the frequency of which depends on the size of the dose used for inoculation of pregnant females. The slow influenza infection developed with similar effectiveness in the progeny of SHK colony mice and C57BL/6 line. As a result of influenza virus infection of pregnant C57BL/6 mice, there were specimens among their progeny devoid of body fur resembling the line of athymic nude mice. It is suggested that the birth of such nude mice is due to reversible changes in the thymus occurring under the influence of influenza virus.

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PubMedDate not supplied

[Experimental slow influenza infection in mice].

In baby mice born to mothers--virus carriers (surviving for various periods after intranasal administration of influenza virus), infectious persisting influenza virus in titres of 10(0.5) to 10(2.5) EID50/0.1 ml was found in the blood, lungs, livers, kidneys, spleens, and brains. Not infrequently, such animals developed a severe pathological process accompanied by growth retardation and characterized by progressive involvement of the hypothalamus, immunocompetent organs, endocrine system and always terminating by the death of the animals. Possible mechanisms of the described slow form of influenza infection are discussed.

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