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V A Zuev

Publications and source records attributed to V A Zuev.

60 records · Page 4Linked to original sources
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[Possible ways of modeling latent influenzae infection in mice].

A latent influenza infection was produced experimentally in three ways: after experiencing the disease, after immunization with a live virus, as a result of vertical transmission of the virus persisting in females. In the latent influenza infection forming after the disease the duration of virus persistence was 112 days postinfection. The persisting virus from the animals receiving a single immunization was isolated only up to 35 days postinoculation. Both after the disease and immunization with a live virus the persisting infectious virus was found in the lungs in low titres not exceeding 1 lg EID50/0.2 ml. In contrast, a latent influenza infection in mice born to mothers-virus carriers was characterized by virus persistence in the blood and viscera in titres of 10(1) to 10(2) EID50/0.1 ml. Features of influenza virus persistence and conditions of its formation in mammals by the three ways mentioned are discussed.

Animals↗
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[The induction by the influenza virus A/H1N1 (serovariant Hsw1N1) and its glycoproteins of congenital pathology in mice].

Influenza A/H1N1 (serovariant Hsw1N1) virus, a sum of isolated glycoproteins, separately neuraminidase "heads", inoculated into white random-bred female mice, induced in some of the offsprings the pathology clinically and pathomorphologically similar to previously described slow virus infection. At the same time, the pathology in the offsprings caused by the antigenic virus variant under study was characterized by complete absence of fur and more dynamic progress of the disease. It is quite obvious that glycoproteins, particularly neuraminidase, are the molecular biological basis of dystrophic and degenerative changes in the organs of baby mice due to desialization and increased fluidity of capillary endothelium membranes and, possibly, CNS and other organ cells.

Animals↗
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[Acute and latent influenzal infection in mice with altered endogenous serotonin metabolism].

A steady and long-term increase of the endogenous serotonine concentration in the lungs, spleen, and brain achieved by administration of nontoxic doses of indopan, an inhibitor of monoamineoxidase, caused a significant decrease of resistance of animals to influenza virus in acute infection. After natural route of inoculation with 20 LD50 of the allantoic influenza A3/WSN (HON1) virus strain in the animals treated with indopan the area of lung affection with specific influenza pneumonia increased, the virus concentration in the lungs and spleen rose sharply, the titre of IgM antibody in the blood decreased; the animal mortality in this group also increased. The level of serotonin in the blood and organs of latently infected animals became normal 6 weeks after virus inoculation. In some of these animals, however, indopan caused a greater increase of serotonin level in the lungs than in intact mice of the same weight and age. Without changing the amine levels in the spleen and the brain, indopan caused 4-16-fold increase in the titer of specific antihemagglutinins in the blood, mostly of IgM fraction, as compared with the controls. In latent influenza infection the balance of serotonin metabolism in the lungs in unstable.

Acute Disease↗
PubMedDate not supplied

[The immunological consequences of congenital infections].

Mice of different strains were inoculated with type A influenza virus or Mycoplasma arthritidis in the second half of pregnancy. A part of the animals born after this inoculation were characterized by a sharp retardation of growth. The study of the immune status of such animals revealed that their proliferative response to mitogenic/superantigenic factors of the infective agents introduced during pregnancy was suppressed or absent, and the cells of their immune system began to recognize syngeneic intact stimulators in the mixed lymphocytes culture as heterogeneous ones. The spleen of the experimental animals was found to contain suppressor cells, both specific and nonspecific with respect to the infective agent. After inoculation with M. arthritidis areactivity was observed only in mice, sensitive to mycoplasmal superantigen. The data thus obtained suggest that the penetration of infecting agents producing mitogenic/superantigenic factors induced changes in the immune system, contributing to the persistence of the infective agent in the host body.

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