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Biomedical subjects

V Baláz

Publications and source records attributed to V Baláz.

At least 19 recordsLinked to original sources
PubMed1990

[Reactive products of oxygen, antioxidative and lysosomal enzymes in the blood cells as markers of aging and indicators for the determination of functional age].

Reactive products of oxygen, lysosomal enzymes, and catalase in PMNL were studied in 174 men of different ages. In two age groups also superoxide dismutase was determined in erythrocytes. Of the given parameters of PMNL markers of aging were selectively established by using the method of correlation analysis and simple linear regression. Combinations of the parameters studied assessed by the method of multivariant linear regression provided equations for calculating the functional age are required due to underestimation or overestimation of the results in the extreme parts of the regression curve.

Adult↗
PubMed1990

[Method of determining functional age from the aspect of immunologic markers of aging].

In a series of 310 subjects partial functional immunochemical age was determined by the method of multivariant linear regression. The authors suggested equations for the determination of partial functional immunochemical age, separately for men, women, and mixed groups, as well as for the determination of global functional age by using parameters of other systems of the body. A possible correction of the equations is discussed with the aim to eliminate the phenomenon of distorted results in the extreme positions of the chronological age axis. The contribution of the method of assessing partial functional immunological age to the selection of relevant markers of aging of the immune system is substantiated and its importance in justifying geroprotective and therapeutic procedures is emphasized.

Adult↗
PubMed1990

[Determination of functional "lipid age" on the basis of analysis of serum fatty acids].

The composition of total fatty acids was analyzed in the serum of subjects with normal lipid and glycide metabolism, aged 20 to 89 years. A mathematico-empirical procedure was applied and on using the method of multiple linear regression the formulas of biological function age, designated as lipid age, were established, with individual serum fatty acids and their ratios in relation to characteristic attributes of markers of aging as independent variable parameters. Further correction of lipid age to the chosen level of 60 years was described and the thus corrected lipid age was expressed in percentages. Application of the obtained formulas of lipid age in the series studied showed that the increase rate of lipid age was higher in men by an average of 5.5% compared to women, which represents a difference of 3.8 years. The obtained results demonstrate a significant relationship of fatty acids to the process of aging and their potential use in evaluating processes affecting lipid metabolism.

Adult↗
PubMed1990

[Functional status of thrombocytes in men of various age groups].

The functional state of thrombocytes was compared in men of three age groups, i.e. below 46 years, within the range of 46 to 59 years, and above 59 years. Thrombocytes of old people were found to be more sensitive to such aggregation inductors as ADP, collagen, arachidonic acid, and adrenaline compared to thrombocytes of subjects from the younger age groups. A further finding was that blood platelets of old men produced significantly greater amount of ATP than recorded in young men and this may account for hyperactivity of thrombocytes in old age.

Adenosine Triphosphate↗
PubMed1990

[Reactive oxygen metabolites, antioxidant activity, antioxidants and aging].

The authors refer to literary data on the much discussed issues of reactive oxygen metabolites, presumably involved in a variety of physiological and pathophysiological processes as well as in ageing. The other part of the paper deals with intra- and extracellular antioxidant mechanisms and the feasibility of using different antioxidants to constrain the deleterious effects produced by reactive oxygen products in pathological processes which accelerate ageing. The authors' own observations are also presented.

Aging↗
PubMed1990

[Determination and assessment of biological age in 40-85-year-old persons].

Biological age was determined separately for men and for women in a series of 120 subjects (66 women) aged 40-85 years (mean age 66 +/- 11.6 years). The established biological age correlated significantly with the chronological age of the subjects investigated. For the calculation of functional age a battery of 10 tests covering 7 functional systems was developed to meet the requirements of the geriatrician and one of 6 tests covering 5 functional systems for the conditions of the general practitioner. The tests are undemanding as to time and procedure and reflect age and sex differences in the population of 40-85 year old people. A new method for the evaluation of biological age was suggested and used, namely the method of interval assessment and of correction of biological age with respect to the chronological age of the proband.

Adult↗
PubMed1986

Age-related changes in human platelet function in vitro.

Platelet aggregation and ATP release were simultaneously measured in platelet-rich plasma samples obtained from humans of various age. In subjects aged over 59 years, an increase was found in platelet sensitivity to ADP and collagen as well as elevated aggregation amplitudes 5 min after induction with low concentrations of the aggregation agents. At 1 mumol/l ADP, old persons had a higher incidence of a secondary aggregation wave. Platelets from old subjects also released more ATP in response to collagen stimulation. Since no age-related changes are commonly found in the platelet count, the observed increase in platelet sensitivity to aggregation agents cannot be regarded as a mere compensatory reaction. An attempt is made to relate altered platelet function to peculiarities of lipid metabolism associated with ageing.

Adenosine Diphosphate↗
PubMed1984

Antibodies against ss-DNA in persons of various age.

Antibodies against denatured, single-stranded deoxyribonucleic acid were measured in the sera of children, young adults and old persons by means of a solid phase enzyme-linked immunosorbent assay using a peroxidase-labelled second antibody. Considerable amounts of anti-deoxyribonucleic acid antibodies were found in subjects in all the age groups studied. Mean serum activity in children and old persons was two times as high as that in young adults. Close correlation was observed in old age between the level of antibodies against single-stranded deoxyribonucleic acid and disorders of lipid metabolism, namely hypertriglyceridemia and hypercholesterolemia. Based on their finding that substantial quantities of antibodies of the above type appear to be present in healthy humans at different stages of ontogenesis, the authors suggest these autoantibodies may play, in addition to pathological, some physiological role.

Adult↗
PubMed1984

[Electron microscopy morphometric analysis of the effect of immobilization stress on the structure of the myocardium in rats belonging to 2 age groups].

13 month-old and 25 month-old Wistar rats were exposed to immobilisation stress and compared with a control group of animals. The most impressive influence was found in mitochondria but there were not any significant changes of myofibrils. The number of mitochondria decreased significantly as well as their relative cytoplasmic volume. Absolute mitochondrial volume increased simultaneously. Difference in age of animals resulted in greater mitochondrial sensibility to stress condition in 25 month-old rats.

Aging↗