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Biomedical subjects

V Chandra

Publications and source records attributed to V Chandra.

90 records · Page 5Linked to original sources
PubMed1976

Effect of prostaglandin 15(R) 15 methyl-E2 methyl ester on aspirin and taurocholic acid-induced gastric mucosal haemorrhage in rats.

The effect of orally administered prostaglandin 15(R)15 methyl-E2 methyl ester on aspirin and taurocholic acid-induced gastric mucosal haemorrhage has been studied in rats. The incidence of haemorrhage induced by aspirin (26-7 mM), 64 mg/kg, together with taurocholic acid (2-5 mM), was significantly reduced from 53-6% to 19-5% by the addition of the prostaglandin (9-9 muM), P less than 0.01. The incidence of haemorrhage induced by aspirin alone (53-3 mM), 128 mg/kg, was significantly reduced from 80% to 20% by the addition of prostaglandin (9-9 muM), P less than 0.002. These results indicate the possible use of synthetic prostaglandins in the prevention of aspirin-induced gastric pathology.

Animals↗
PubMedDate not supplied

Psychiatric symptoms in cases of clinically diagnosed Alzheimer's disease.

All incident cases of clinically diagnosed Alzheimer's disease were identified through the unique record linkage system of the Mayo Clinic. Thirty-nine (32%) of the sample of 122 had a psychiatric history that preceded the onset of CDAD by at least 3 years. Twenty-five percent of the study population had had an episode of delirium within 2 years of the onset of CDAD. Eighty-four percent of the cases had psychiatric symptoms in the course of CDAD that were documented in their medical records. Specific symptom patterns included agitation, combativeness, confusion and disorientation, depression, psychosis, and wandering. These symptoms occurred more frequently in clusters than singularly.

Aged↗
PubMedDate not supplied

Renal artery stenosis and a functioning hilar paraganglioma: a rare cause of renovascular hypertension--a case report.

Surgically correctable causes of hypertension are uncommon. Simultaneous occurrence of 2 such causes in the same individual is extremely rare. The authors describe a 25-year-old woman with congenital erythrocytosis, renal artery stenosis, and a paraganglioma. The possible mechanisms of renal artery stenosis in the presence of a catecholamine-secreting tumor are discussed.

Adult↗
PubMedDate not supplied

Cardiac acceleration by angiotensin II in dogs.

The effect of angiotensin II on heart rate of dogs were studied by intravenous and intracerebroventricular routes. Following differences were noticeable when the results obtained with intracerebroventricular were compared with those obtained after intravenous administration. The onset of tachycardia was less as compared to the intravenously administered angiotensin. The dogs required to produce tachycardia was less and the magnitude of tachycardia was also greater with intracerebroventricular administration. The initial bradycardia observed with intracerebroventricular or intravenous administration of angiotensin, could be prevented by using the mechanical buffering device. The spinal cord transection at C2 level and bilateral vagotomy abolished the tachycardia. It is speculated that angiotensin acts centrally either on the hypothalamic or medullary accelerator neurones (central sympathetic structures) and produces some degree of increased adrenegic neuron discharge which is responsible for cardiac acceleratin in dogs.

Angiotensin II↗
PubMedDate not supplied

Modification of vascular response to synthetic oxytocin by oestrogen in rabbit.

Intravenously administered oxytocin caused a dose-related fall in blood pressure of the rabbit. When oxytocin was administered in oestrogen-primed animals, the depressor response was converted to a pressor one "Oxytocin reversal". The "oxytocin reversal." was abolished after treatment with dihydroergotamine, hexamethonium or adrenalectomy. The "oxytocin reversal" did not appear in reserpinized animals.

Adrenalectomy↗
PubMedDate not supplied

Angiotensin induced changes in blood glucose level.

Angiotensin given by intravenous route in rabbits caused a marked rise in blood glucose within 45 min. Guanethidine, bretylium, alpha methyl DOPA, adrenalectomy and reserpinization significantly influenced the changes in blood glucose induced by angiotensin II. It is suggested that the rise in blood glucose level induced by angiotensin II appears to be mediated by facilitation of catecholamine release or due to inhibition of reuptake.

Adrenalectomy↗
PubMedDate not supplied

Effect of insulin on blood cholesterol.

The effect of plain insulin was studied in normal mongrel dogs on blood cholesterol level. Intravenous administration of plain insulin in different doses on different groups of dogs does not cause any significant change in blood cholesterol level over a period extending upto 5 hrs. Exogenous insulin neither has any direct nor indirect effect on cholesterol metabolism in dogs.

Animals↗
PubMedDate not supplied

Role of catecholamines in angiotensin induced hyperglycaemia.

The effects of angiotensin II were studied on blood sugar level in dogs. Intracerebroventricular administration of pressor dose of angiotensin caused a rise in blood sugar level. The hyperglycaemia and pressor response was not affected by bilateral vagotomy and was less marked in adrenalectomized dogs. The hyperglycaemic effect and pressor response was not observed in reserpinized and spinal vagotomized dogs. It is suggested that centrally administered angiotensin stimulates the hypothalamic or medullary accelerator neurons (central sympathetic structures) to cause a marked release of catecholamines from peripheral stores specially adrenal medulla. This excessive release of catecholamines is responsible for hyperglycaemia and pressor response of angiotensin II in dogs.

Adrenal Glands↗