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Biomedical subjects

V Chandra

Publications and source records attributed to V Chandra.

At least 73 records · Page 4Linked to original sources
PubMed1983

The impact of marital status on survival after an acute myocardial infarction: a population-based study.

A nonconcurrent prospective study was conducted in the metropolitan Baltimore, Maryland, area to examine the influence of marital status on the in-hospital and long-term survival rate of 1401 patients who experienced an acute myocardial infarction. Patients were classified as "married" or "unmarried" at the time of their myocardial infarction and any later change in the marital history was not considered. For married males the adjusted in-hospital case fatality rate was 19.7 per cent, whereas for unmarried males the rate was 26.7 per cent (p less than 0.05); similarly, the case fatality rate for married and unmarried females was 23.3 per cent and 37.4 per cent, respectively (p less than 0.05). A 10-year follow-up of 888 subjects who were discharged alive after an acute myocardial infarction also showed a significantly better survival rate for the married compared to the unmarried for both males (p less than 0.0001) and females (p less than 0.025). The results of this study indicate that married men and women who experience an acute myocardial infarction have a significantly better survival prospect, both in-hospital and after discharge, independent of other factors.

Female↗
PubMed1981

Meningioma size. Its relationship to other diseases.

In an autopsy study of 7.345 cases from a 20-year period, 76 cases of meningiomas were noted. Meningiomas in the diameter range of 0.5 to 2.7 cm ("small" meningiomas) were significantly associated with extraneural malignancies and chronic renal failure as opposed to those in the diameter range of 2.8 to 10.5 cm ("large" meningiomas). These data suggest that small meningiomas may be nosologically distinct from large meningiomas. When discovered at autopsy, small meningiomas may not be "incidental" in the sense of being do novo phenomena of chance occurrence.

Humans↗
PubMed1980

Arachnoidal cell hyperplasia. Its relationship to aging and chronic renal failure.

The biological implications of human arachnoidal cell hyperplasia are unclear. In a study based on 922 autopsies performed over a four-year period that investigated the conditions associated with arachnoidal cell hyperplasia, hyperplasia was found in 184 cases (study cases). The incidence of arachnoidal cell hyperplasia was found to increase linearly with advancing age. In a case-control design used to ascertain any other clinical associations, 22 of the study cases had comcomitant chronic renal failure, whereas only four in a control group matched for age at time of death had chronic renal failure. No other associations were observed. Arachnoidal cell hyperplasia seems to be an age-related phenomenon and shows a statistically significant association with chronic renal failure.

Adolescent↗
PubMed1979

Association of meningiomas with extraneural primary malignancy.

In an autopsy-based, case-control study of meningiomas over a 20-year period, there were 76 patients with meningiomas, and 20 of them also had an extraneural primary malignancy. In two control populations with autopsy-proved central nervous system (CNS) pathology (group I) and non-CNS pathology (group II), extraneural primary malignancies were seen in two patients in group I and in seven patients in group II. There was a high degree of statistical association between meningioma and extraneural primary malignancy (chi2 = 17.22, p less than 0.005 group I and chi2 = 7.61, p less than 0.01 group II). Screening of patients with meningioma for extraneural primary malignancy, and of patients with extraneural primary malignancy for meningioma are strongly indicated for the benefit of the patients as well as for further elucidation of the etiologic and temporal relationships between the two conditions.

Adolescent↗
PubMed1978

Effectiveness of increasing hours of continuous ambulatory electrocardiography in detecting maximal ventricular ectopy. Continuous 48 hour study of patients with coronary heart disease and normal subjects.

The effectiveness of 1, 6, 12, 24, 36 and 48 hours of continuous ambulatory electrocardiographic examination in detecting maximal ventricular ectopy was studied in 67 patients with coronary heart disease (45 with myocardial infarction, 22 with angina pectoris) and 23 normal subjects. Two consecutive 24 hour Holter recording examinations provided 48 hours of continuous examination. Ventricular ectopy was detected in 87 percent of patients and 35 percent of normal subjects. Complex forms (multifocal or repetitive patterns) were found in 62 percent and high frequency ectopy (greater than 60/hour) in 30 percent of the patients with coronary heart disease. Examination of either the initial hour of study or an hour of dynamic activity frequently failed to reveal the maximal ventricular ectopy present, particularly with regard to complex types and high frequency. Continuous 6 and 12 hour examinations were less effective than the 24 hour examination, which detected the maximal grade of ventricular ectopy in 71 to 74 percent and the maximal frequency in 58 to 83 percent of patients with coronary heart disease. Detection of maximal complex types and high frequency of ventricular ectopy was one to three times greater with a continuous 24 hour examination than with studies of shorter duration. Patient-recorded diaries showed that 50 to 80 percent of patients were engaged in mild to moderate activity during ventricular ectopy and only 9 percent indicated symptoms during the hours of maximal ventricular ectopy.

Angina Pectoris↗
PubMed1977

The effect of the synthetic prostaglandin analog 15 (R) 15 methyl-PGE2 methyl ester on gastric mucosal hemorrhage induced in rats by taurocholic acid and hydrochloric acid.

The incidence of mucosal hemorrhage induced in rats by the oral administration of taurocholic acid (TCA) and hydrochloric acid (HCl) both singly and in combination was investigated. The effect of prostaglandin 15 (R) 15 methyl-PGE2 methyl ester (Me-PGE2) on the occurrence of hemorrhage induced by TCA with HCl was also studied. The incidence of hemorrhage induced by TCA (10 mM) alone and HCl (160 mM) alone was minimal and not different from that induced by the control solution. The combination of TCA (10 mM) and HCl (160 mM) produced bleeding in 67.7% of animals. The addition of 15 (R) 15 methyl-PGE2 methyl ester (9.9 micronM, corresponding to 50 microng/Kg) significantly reduced the incidence of hemorrhage induced by the combination of TCA with HCl from 67.7% to 31.3%. This suggests that this synthetic prostaglandin may be of value in conditions thought to be associated with reflux of bile into the stomach.

Animals↗