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Biomedical subjects

V Colletti

Publications and source records attributed to V Colletti.

At least 55 records · Page 3Linked to original sources
PubMed1991

Surgery vs. natural course of chronic otitis media. Long-term hearing evaluation.

The present paper investigates the hearing function in chronic otitis media vs. tympanoplasty in 41 patients with bilateral chronic otitis media, operated on unilaterally. The auditory evaluation was performed immediately before surgery and at a follow-up time varying from 1 to 14 years (mean = 5 years). Results were expressed in terms of relative gain (in respect to preoperative hearing levels) and total gain (in comparison with the contralateral ear). A progressive reduction of the hearing threshold as a function of time was observed both in non-operated and operated ears. The comparison of the threshold shifts between the two ears indicated that the long-term functional results of tympanoplasty can be considered quite satisfactory.

Adult↗
PubMed1991

Effect of sodium fluoride on early stages of otosclerosis.

The present investigation evaluates the effectiveness of NaF treatment in modifying the natural course of subclinical otosclerosis, as monitored by the stapedius reflex. The study was carried out on 128 relatives of patients suffering from surgically confirmed footplate otosclerosis. The diagnosis of subclinical otosclerosis was made on the basis of presence of the on-off effect. One group of subjects was treated with NaF in doses ranging from 6 to 16 mg according to age. The treatment lasted 2 years. A second group served as a control. Changes in stapedius reflex morphology were evaluated at 1, 2, and 5 years from the onset of treatment. The investigation demonstrated that NaF has a stabilizing effect on early otosclerosis. This drug, in fact, arrests the disease process in more than 60 percent of ears at the 2-year follow-up and in more than 50 percent at 5 years. A program of secondary prevention of otosclerosis by NaF is suggested.

Adolescent↗
PubMed1989

NaCl deposition in the vestibule: a simple, safe, and effective method of cochleovestibular deafferentation.

Chemical cochleovestibular deafferentation was performed on 21 individuals suffering from disabling vertigo caused by unilateral Menière's disease. Patients ranged in age from 31 to 60 years, with a mean age of 47.4. The duration of the disease spanned 3 to 14 years, mean duration being 5.8 years. Subjects displayed pure-tone thresholds higher than 50 dB HL in the affected ear and better than 25 dB HL in the contralateral ear. The frequency of vertigo, evaluated during the 6 months before surgery, ranged from 1 crisis a month to 2 a week; mean duration of crises was 1 to 6 hours. Medical treatment had failed in all cases. The surgical procedure consisted of stapedectomy, deposition of several crystals of NaCl in the vestibule, and sealing of the oval window with a vein graft. Postoperative recovery was rapid, allowing patients to be discharged 4 to 6 days after surgery. All subjects reported complete relief of vertigo. Tinnitus disappeared in 47.6% of the subjects, was reduced in 33.3% and unchanged in 19.1%. Most patients complaining of aural fullness preoperatively reported relief of this symptom after surgery. The outcomes of the present study indicate that NaCl deposition into the vestibule is a simple, safe, and effective technique of cochleovestibular deafferentation.

Adult↗
PubMed1988

Investigation of the long-term effects of unilateral hearing loss in adults.

The recent audiological literature has put forward the hypothesis that children with unilateral hearing loss (UHL) show delays in educational achievement and academic progress and some behavioural difficulties. This motivated us to investigate the long-term effects of monaural auditory deprivation in a group of adults who had suffered from UHL since childhood. A group of subjects, ranging in age from 30 to 55 years, suffering from sensorineural UHL since early childhood, has been examined for psychosocial and psychoacoustical effects and statistically compared with a control group matched for age and sex. We prepared a questionnaire directed to provide some objective and subjective indices of psychosocial disability and handicap. Some questions were directed towards specific aspects of auditory function; others assessed the degree of education and the type of working performed. The results of the investigation confirmed the superiority of binaural v. monaural hearing. This was clearly demonstrated in psycho-acoustical performance in sound localisation, speech recognition in noise, together with the appreciation of music. On the other hand, the parameters concerned with educational, social and employment achievement did not support the existence of any significant difference between binaurally and monaurally hearing subjects. The data obtained in the present study thus do not support the existence of non-auditory, long-term effects of monaural hearing loss.

Achievement↗
PubMed1988

Stapedotomy with and without stapedius tendon preservation versus stapedectomy: long-term results.

Stapedectomy and stapedotomy are presently the techniques utilized in the surgical treatment of otosclerosis. The technique of choice at the ENT Department of the University of Verona has changed from stapedectomy to stapedotomy with and without stapedius tendon preservation. From January 1975 to December 1985, 805 ears were operated on for otosclerosis at our department. A statistical analysis has been performed on three groups of patients (stapedectomy, stapedotomy without and with stapedius tendon preservation) at short and long term. The results suggest that stapedotomy with stapedius tendon preservation should be the preferred surgery in the treatment of otosclerosis.

Adolescent↗
PubMed1987

Minisculptured ossicle grafts versus implants: long-term results.

The present study deals with 832 ossicular chain reconstruction procedures performed in 655 patients from January 1975 to December 1985. Homograft and autograft ossicles, intraoperatively minisculptured according to personal or traditional techniques, were used in 626 ears (75.2%). In the remaining 206 ears Plastipore or Proplast total or partial ossicular replacement prostheses were employed. The functional hearing results are evaluated as a function of length of follow-up, techniques used, and preoperative diagnosis. Short-term hearing gain is satisfactory and very similar for both ossicles and implants. Long-term observation however, shows, a progressive and systematic reduction of the postoperative hearing gain for both treatments. The long-term deterioration of hearing levels in ears receiving implants is more evident and dramatic than that observed in ears with ossicles. The difference is statistically significant. The causes of failure are evaluated based on both clinical data and findings at revision surgery.

Adolescent↗
PubMed1984

Mechanics of the TORP/stapes interface.

The gain in hearing as a result of ossicular prosthesis ( TORP ) placement on the stapes footplate was evaluated in 10 patients during actual middle ear reconstructive surgery. The patients with radical mastoidectomy cavities were operated on under local anaesthesia and intra-operative hearing was tested with the TORP shaft in three positions with regard to the stapes footplate; anterior, central and posterior. The anterior position of the shaft provided greater hearing improvement than the posterior position, with the central position falling approximately midway.

Adult↗
PubMed1983

BSER abnormalities in patients with spino-cerebellar degeneration.

The short latency auditory electrical response (BSER) was evaluated in 15 patients suffering from spino-cerebellar atrophy (SCA). All patients had normal hearing and presented with various degrees of neurological involvement. BSER findings along with clinical symptoms furnished the following grouping of results: 1 Patients with recent and mild symptomatology showed excellent intratest stability, normal III-V and prolonged I-V and I-III interpeak values. 2 Patients with severe symptoms dating back 10-15 y showed low intratest stability, prolonged latency of waves I, III and V, along with remarkably lengthened I-III and III-V interpeak intervals. 3 Patients with moderate to severe symptoms, dating back 10-15 yr showed good stability, absence of wave II and IV, abnormally long I-III intervals and reduced III-V intervals.

Adult↗
PubMed1983

Fluid-solute regulation systems in patients with Meniere's disease.

A comprehensive endocrinologic evaluation of water electrolyte balance system was performed on 25 patients with Meniere's disease, 6 persons with sudden deafness, and 20 normal persons. In the controlled environment, the following studies were performed: (1) plasma and urine NA+K+ and Cl-, (2) plasma 17-ketosteroid and 17-hydroxysteroids, (3) plasma cortisol and ACTH, (4) urine steroids, (5) urinary excretion of aldosterone, (6) plasma activity of the renin (PRA) in clinostatism and in orthostatism, (7) plasma aldosterone in clinostatism and orthostatism. In patients with Meniere's disease and sudden deafness, the walter-electrolyte balance results were normal, as were the hormonal system directly (renin-aldosterone) or indirectly (cortisol-ACTH) involved. A further confirmation of the integrity of the explored enzymatic-endocrinologic complex derived from the normal response observed in all patients when they were subjected to a physiologic stimulus as represented by the orthostatism. The results of the present study do not confirm previous findings by Arenberg and Goodfriend.

17-Ketosteroids↗
PubMed1976

Tympanomety from 200 to 2000 Hz probe tone.

Previous investigations have shown that the probe tone frequency is the main factor in determing the shape of the tympanogram. These had, however, been limited up to 800 Hz. In the present paper, a multifrequency investigation (from 200 to 2000 Hz) has been performed on 72 ears with different pathophysiological conditions of the middle ear. From the analysis of the result some new critical aspects of tympanometry emerge. The multifrequency tympanometric investigation proves to be, according to our experience, a far more sensitive method for checking small changes in the transmission characteristics of the tympano-ossicular system than the monofrequency traditional analysis. In this connection, the technique seems to furnish a simple and reliable method for discriminating between stiffness versus mass-controlled systems.

Audiometry↗
PubMedDate not supplied

Auditory brainstem implant in posttraumatic cochlear nerve avulsion.

Patients aged over 12 years with neurofibromatosis type 2 are considered candidates for an auditory brainstem implant (ABI). This study extends the indication criteria of ABI to subjects with profound hearing loss due to damaged cochleas and/or cochlear nerves (CNs) following head injuries. In our department, over the period from April 1997 to November 2002, 32 patients, 23 adults and 9 children, were fitted with ABIs. Their ages ranged from 14 months to 70 years. These patients were suffering from a variety of tumor (13 subjects) and nontumor CN or cochlear diseases (19 subjects). Six patients, 5 adults and 1 child, had profound hearing loss following head injury. Their mean age was 25 years (range: 16-48 years). Five were male and 1 female. The retrosigmoid approach was used in all 6 patients. The electrode array was inserted into the lateral recess of the fourth ventricle and correct electrode positioning was monitored with the aid of electrically evoked auditory brainstem responses and neural response telemetry. Correct implantation was achieved in all patients. No complications were observed due to implantation surgery or related to ABI activation and stimulation of the cochlear nuclei. At activation, an average of 9.8 electrodes (range 5-13) were switched on without side effects. One to 6 electrodes were activated in the following sessions after time periods ranging from 2 to 16 months. All patients achieved auditory-alone-mode closed-set word recognition scores ranging from 40 to 100%; 3 had auditory-alone-mode open-set sentence recognition scores of 60-100%; 2 of these even had speech-tracking performance scores of 38 and 43 words, respectively, showing an ability to engage in normal conversation and converse over the phone. The present study demonstrates that the ABI is a useful rehabilitation instrument in subjects with damaged cochleas and/or CN avulsion following head injury who are unamenable or poorly responsive to auditory rehabilitation using cochlear implants.

Adolescent↗
PubMedDate not supplied

Methodologic observations on tympanometry with regard to the probe tone frequency.

Changes in the tympanogram shape in the frequency range from 200 to 2000 Hz have been investigated. The tympanogram undergoes, as the probe tone frequency rises, characteristic morphologic modifications which are consistently observed both in normals and in some middle ear disorders. The only exception to this regular behavior is the pathological picture in which the structure or the dynamic of the tympano-ossicular system is remarkably anomalous (cholesteatoma and otitis media) where there are flat tympanograms. It is suggested that the frequency interval at which one of the characteristic tympanometric configurations appears in the element capable of furnishing a diagnostic tool for differentiating pathophysiologic conditions of the middle ear.

Air Pressure↗
PubMedDate not supplied

An experimental study of inner ear pathology due to NaCl on the round window.

An animal experiment was performed to evaluate structural and ultrastructural changes to the inner ear as a result of placing 3-4 crystals of reagent grade sodium chloride (NaCl) on the round window membrane. Chinchillas were sacrificed at 8 and 24 hours after treatment and the cochlear and vestibular tissues were examined by light microscopy and scanning electron microscopy. Inner ear pathology consisted of destruction of both sensory and supporting cells in the basal turn of the organ of Corti, atrophy of the stria vascularis and alterations to the otoconia and the maculae and ampullae of the vestibular system. This study demonstrates that NaCl in the middle ear does not provide a model for Meniere's disease as previously suggested by Arslan. It may, however, be utilized in the destructive treatment of selected inner ear disorders.

Animals↗
PubMedDate not supplied

Experimental cochleo-vestibular deafferentation with NaCl.

An animal experiment was performed to evaluate structural and ultrastructural changes in the inner ear as a result of placing 10-12 crystals of reagent grade sodium chloride (NaCl) in the vestibule. Chinchillas were sacrificed 8 and 24 hours after treatment and the cochlear and vestibular tissues were examined by light microscopy and scanning electron microscopy. Inner ear pathology consisted of extensive degenerative changes in morphology of all sensory structures of the inner ear. The extent of these pathological changes supports the idea of eventual total deafferentation of the inner ear.

Afferent Pathways↗