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V D Slepushkin

Publications and source records attributed to V D Slepushkin.

93 records · Page 6Linked to original sources
PubMedDate not supplied

[Use of clofelin as an anesthetic and component of neurovegetative defense in ENT oncologic surgery].

Metabolism indices (blood sugar, lactic acid, pyruvic acid) and hemodynamics (mean arterial pressure, 1-hour diuresis) were measured in 41 hypertensive subjects undergoing resection or removal of the larynx for cancer under endotracheal anesthesia through tracheostoma. 18 patients of group 1 received calypsol anesthesia, whereas 23 patients of group 2 received combination of calypsol with clofelin. Croup 2 patients benefited more because clofelin potentiated the analgetic effect of calypsol, intensified neurovegetative block, promoted more rapid recovery of normal respiration, prolonged analgetic effect in postoperative period.

Adult↗
PubMedDate not supplied

[Effectiveness of the use of synthetic opioid peptide in rats with traumatic shock].

Experiments were conducted on 80 male Wistar rats. Traumatic shock was simulated by applying clamps to lower extremity soft tissue for 6 hours. After removing the clamps, experimental animals were intraperitoneally injected the synthetic leucine-enkephalin dalargin. The blood ionogram, the levels of urea, glucose, phosphorus, creatinine, lactic and pyruvic acids, blood plasma osmolarity, LDH activity were determined. In the animals untreated with dalargin, plasma concentrations of ions of potassium, phosphorus, creatinine, urea, osmolarity, LDH activity increased and the levels of glucose decreased when shock developed. At the same time the rat death rates were 70-80% 24 hours later. The administration of dalargin corrected the majority of the above-mentioned parameters and the death rates were decreased to 20%. It is concluded that dalargin has an early antishock effect.

Animals↗