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Biomedical subjects

V Dimitrov

Publications and source records attributed to V Dimitrov.

At least 37 records · Page 2Linked to original sources
PubMed1991

[The tumor markers CEA and CA-19.9 in patients with colorectal carcinoma].

The levels of two tumor markers--CEA and CA-19.9 were repeatedly determined in 146 patients with histologically verified colo-rectal cancer and in 58 healthy controls. The normal CA-19.9 values were up to 30 U/ml. The sensitivity of the two markers proved to be low: 48.8 per cent for CEA and 37 per cent for CA-19.9. In 26 of 35 patients with local recurrence or metastases marker increase preceded the appearance of clinical symptoms of progression of the pathologic process. The two markers appeared more informative than each of them when separately determined.

Adult↗
PubMed1990

[The results of using a new surgical method in carcinomas located in the proximal portion of the lower third of the rectum].

A new type of abdomino-transanal resection of the rectum instead of its extirpation is being applied in tumors localized in the proximal part of the lower one third of rectum (5-6 cm from the anorectal line). For removing the whole lymph collector of the lower one third of the rectum the authors remove the levator tunnel as well. What remains intact is only the anal mucosa and the external anal sphincters. The anastomosis is realized by preliminary placing all catgut. Prophylactic transversostoma is also an obligatory procedure, so that the anal sphincters may remain at rest for 2-3 months after the operation. During this time the anal sphincters and the neorectum are fixed to the adjacent tissues and the anal tonus is fully restored. This operation was applied in 15 patients with very good result, as regards anal continence, without any case of relapse of the tumor so far.

Anal Canal↗
PubMed1990

[The use of a new method for the restoration of duodenal passage following the partial extirpation of its wall in treating locally advanced tumors of the right half of the colon].

When excision of the tumor infiltration of the duodenum is followed by formation of a small defect, the authors apply a personal modification of two-story suture. Then the duodenal suture is fully covered with the serosa of the small-intestinal loop. Thus the suture is hermetically sealed and remains in a relative rest. When a large defect remains after excision of the tumor infiltration of the duodenum, a short jejunal loop is taken and a longitudinal section is made on it of equal length with that of the duodenal defect. Laterolateral anastomosis is made between the duodenal defect and the jejunum. Brown's anastomosis is made somewhat distally from the duodenojejunostomy. In this way the duodenum is not narrowed, the tissues are sutured without any tension and postoperative duodenal stasis is minimal. The first variant of the method was applied in 3 patients and the second in 3 patients with very good postoperative result.

Aged↗
PubMed1990

[The results of the formation of a new anal sphincter by using the mm. graciles in acquired anal incontinence].

The operative method of Pickrell for shaping a new anal sphincter from mm.graciles is described, emphasizing the refinements which the authors have introduced in it. In mobilizing the muscle, fascial fibers are left on both sides of the vascular-nervous bundle. They prevent the latter from overdistension when the muscle turns around the anal canal. Two arcuate lateral sections are made in the perianal area; this is followed by driving a subcutaneous tunnel, but under the perineal raphe and the anococcygeal ligaments. The two muscles are perianally wound each on 360 degrees, whereby m.gracilis dex. is fixed to tub. ossis ischii sin. and m.gracilis sin. is fixed to tub. ossis ischii dex. Before being fixed, the tendon end is inserted in the subperiosteal bone tunnel. When the tendon of the muscle is shorter, it may successfully be elongated by the explantoplast Ampoxen (applied in 3 patients). A total of 16 patients were treated. The result was good in 15 (93.8 per cent) and unsatisfactory in 1 (6.2 per cent).

Anal Canal↗
PubMed1990

[The use of a new plastic method for consolidating a preternatural anus as prevention in paracolostomy hernias].

Once the stage of extraperitoneal evasion of the sigmoid has been achieved for definitive preternatural anus, transsection is made of the aponeurosis of m. obliqu. ext. abdominis along its tendon fibers at a length of 5-6 cm. Then an aperture is made along the muscle fibers with the same length on m. obliqu. int. abdominis and m. transversus abdominis as well and finally f. transversalis is transsected. The peritoneum is intra-abdominally detached from the fascia beneath and alongside the aperture. An "Ampoxen" layer is placed around the internal aperture of the abdominal wall. The explant is sutured to the fascia and the evaded sigmoid. The latter is sutured to the aponeurosis of m. obliqu. ext. abdominis. Another Ampoxen layer is placed over this aponeurosis and sutured to the evaded intestine and in a chess-board way to the fascia. The method was applied in 22 patients with very good postoperative result.

Adult↗
PubMed1990

[The therapeutic effect of somofilin in bronchial asthma patients].

The sustained release theophylline drug Somophylline in capsules was applied in 21 asthmatic patients (12 women and 9 men), mean age 44.5 years in the course of 14 days in hospital conditions. The dose of the drug was 9-10 mg/kg body mass (24 h given in two equal doses in 12 h intervals). The effect was favourable in 17 patients (80.95%), weak--in 2 patients (9.52%) and no effect in 2 patients (9.52%). Somophylline is very well tolerated. The blood level remains in the therapeutic ranges during the treatment (about 10 micrograms/ml).

Adult↗
PubMed1990

[The use of the preparation defedrin in the therapy of bronchial asthma patients].

The therapeutic efficacy of the Soviet drug Dephedrin was tried in patients with mild and moderate form of bronchial asthma. The drug was administered in a dose of 0.03 g 3 times daily for a period of 15 days. Out of 10 patients with mild form of bronchial asthma in patients the effect was very good, in 5 patients it was good and in patient it was poor. Out of 10 patients with moderate form of bronchial asthma in 3 patients the effect was very good, in 3 patients it was good and in 4 patients--poor. The ventilation indices improved but without reacting statistical significance. The conclusion is that Dephedrin is suitable for the mild form of bronchial asthma.

Asthma↗
PubMed1989

Chaetotaxy of cercariae of Opisthioglyphe ranae (Frölich, 1791) (Trematoda: Plagiorchidae).

A detailed observation of the sensory apparatus of Opisthioglyphe ranae (Frölich, 1791) cercariae was carried out. The species was determined on the basis of an experimental study of the life cycle and morphology of sporocysts, cercariae, metacercariae, and adults. In contrast to other species of the family Plagiorchidae, no papillae were present in the positions CId1, CId2, CII0, CII3 and CII4. Papillae with markedly ventral situation on the postacetabular zone were found very rarely. Some of the cercariae possessed ventral papillae variously distributed in the preacetabular zone. A comparative analysis of the chaetotaxy revealed that the cercaria studied by us was very similar to Cercaria 4 of Richard, 1971, with the exception of the number of acetabular papillae and some groups of ventral papillae. Compared to the cercaria of O. ranae studied by Dobrovolskiy (1965). AID papillae and a part of ventral papillae were distributed differently. The chaetotaxy was identical with that of experimentally obtained cercariae of O. ranae from L. stagnalis and of cercariae of the same species obtained from Bulgaria.

Animals↗
PubMed1989

[The use of a transabdominal method in treating inguinofemoral hernia simultaneously with surgery of the rectum or sigmoid in carcinoma].

Detailed description is given of inguinofemoral herniotomy with subsequent plastic repair through transabdominal approach simultaneously with radical oncologic operation of sigmoid and rectum. The plastic repair is a two-stage procedure: The first stage consists of suturing the musculo-aponeurotic part of m. transversalis and m. obliq. internus abdominis to lig. inguinalis or lig. inguinalis to lig. Cooperi in femoral hernias. The second stage is the "ampoxen" explant, which is sutured cranially to f. transversalis, medially to the fascia behind m. rectus abdominis, downward to the public or obturator fascia and laterally to the fascia over m. iliopsoas. The explant serves as a firm "umbrella" from the internal part of the entire inguinofemoral area. The method was applied on 7 patients with very good postoperative result.

Abdomen↗
PubMed1989

[The results of using necessarily low anterior resections for carcinoma of the lower half of the middle third of the rectum].

Compulsively low anterior resection of rectum was performed in patients with tumor localized in the lower half of the middle one third of the rectum (7-10 cm from the anorectal line) and vague vascular arcades in the left half of the colon or having very fat meso. The following technique was applied: The left half of the colon was mobilized, releasing it from the gastrocolic junction, and the rectum--to the anal sphincters; One-stage anastomosis with step-like course of the catgut was performed, threading it previously to the posterior and lateral parts of the anastomosis and on the anterior wall--to the rectal stump only; when the anastomosis was performed, the catgut was passed through the upper pelvic diaphragmatic fascia as well. The method was applied on 19 patients; the first six of them had prophylactic transversostomy performed. In none of the patients was insufficiency of the anastomosis or recurrence of the tumor observed.

Aged↗