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V F Popov

Publications and source records attributed to V F Popov.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Safety, antigenic activity, and epidemiologic effectiveness of live mumps vaccine from strain L-3. II. Antigenic activity and epidemiologic effectiveness].

The results obtained in the study of the antigenic activity and epidemiological effectiveness of live parotitis vaccine prepared from strain L-3 are presented. Children aged 3-7 years were shown to react to the injection of this preparation by the moderate production of virus-neutralizing antibodies (the percentage of persons with antibody titers of 1:8 and higher increased from 26.5 to 64.4). The most intensive antibody production was stimulated by the vaccines containing 40,000 and 20,000 viral particles in 1 vaccination dose. In seropositive children no significant shift in the antibody content was observed irrespective of the batch of the vaccine used. During 1 1/2 years of observation the morbidity rate of epidemic parotitis among children immunized with live parotitis vaccine was 6.9 times lower than among the unvaccinated children in the same groups and 8.8 times lower than among the children used as external control. The effectiveness rate of the vaccine was on the average 85.4% and 88.6%. The vaccines containing 40,000 and 20,000 HADU50 were found to have greater epidemiological effectiveness, while the epidemiological effectiveness of the vaccine containing 5,000 HADU50 was somewhat less. The effect of vaccination depended not only on the dose of the antigen and the initial state of the vaccines, but also on the extent of the coverage of children with vaccination in organized groups.

Antibodies, Viral↗
PubMed1973

The status of measles after five years of mass vaccination in the USSR.

Mass vaccination of children from 10 months to 8 years old with the original live vaccine prepared from the Leningrad-16 strain has led to a sharp decline in measles morbidity and mortality, and changed its epidemic pattern. In 1972, after 5 years of mass vaccination, the morbidity rate was 117.5 per 100 000 persons, whereas before vaccination the average annual morbidity rate was about 827.0. The periodicity of increases in morbidity every 3 years was also broken, the last peak of measles morbidity occurring in 1965. Another result of vaccination is that the formerly much higher morbidity rate in urban areas is now lower than that in rural areas. The mortality rate decreased more than 3-fold compared with the period before vaccination, and recently no deaths were registered in a number of regions. The serologic examination of 7 585 vaccinated children from 10 different regions revealed antibodies with a mean geometric titre of 78.6+/-1.16 in 90% of individuals. The high antibody level was maintained for 7 years after vaccination. The effect of vaccination is both epidemiological and economical. The saving in the use of gamma-globulin alone covered the cost of the vaccine and the expenses involved during vaccination.

Antibodies, Viral↗