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Biomedical subjects

V I Chissov

Publications and source records attributed to V I Chissov.

At least 19 recordsLinked to original sources
PubMed2006

[Application of cell technologies to tissue defect closure in oncology].

In vivo and in vitro experiments on the application of cell technologies to tissue defect closure were conducted; autologic mesenchymal stem cells on 3-demensional matrices were used. The authors analyze the results of the application of bioengineering tissue equivalents for the closure of soft tissue and upper airway defects after extensive resections performed in 52 oncological patients. Tissue equivalents with stem cells provide engraftment and long-term graft functioning; they also modify wound surface, thus stimulating wound epithelization. In this study the application of tissue equivalents led to wound healing and functional recovery in 87% of patients.

Follow-Up Studies↗
PubMed1999

[Stomach precancer].

The study was made of 568 cases of "initial" cancer cases, 825 morphological substrates of the polyps and 90 ones of chronic gastric ulcer. Chronic gastritis was the most frequent precancer disease (88.7% of cases). Malignant polyps accounted for 10.7% and chronic ulcer for 0.6% of cases. Relevant criteria for risk groups are proposed. Severe epithelial dysplasia as a morphological manifestation of gastric precancer can serve a marker of the risk of malignant transformation.

Adult↗
PubMed1999

[Microsurgical autotransplantation of organs and tissues in oncologic patients].

402 patients with tumors of the head, neck and gastrointestinal tract as well as of the locomotor system underwent microsurgical autotransplantation of tissues during the treatment and rehabilitation. 483 microsurgical autografts from fascio-cutaneous, muscular and osseous tissues were used as well as from visceral organs (the stomach, omenthum, the bowels). Successful outcomes of plastic and reconstructive operations were obtained in 95% of all the cases. Successful microsurgical plastics favoured timely application of combined antitumor treatment. In 50-60% of oncological patients a complete social and labour rehabilitation was achieved. The method proved to be perspective for further development and implementation in oncology.

Humans↗
PubMed1998

[Should desmoid fibromas be operated?].

The 30-year experience of P.A. Herzen Moscou Cancer Research Institute in the treatment of soft tissue desmoid fibromas (DF) is summarized. A comparative study of effectiveness of surgical, combined, radiation and medicamentous methods was carried out. Frequency of recurrences after surgical treatment made up 94%, after combined treatment with preoperative radiation it decreased 3-fold (27.5%), in cases of postoperative radiation it made up 53%, and after radiation therapy--15.7%. However radiation therapy may have limitations due to necessity for irradiation of large tumour masses and usage of high-dose ionized irradiation which results in development of postradiation tissue damages. Further research brought about an original chemohormonal therapy (tamoxiphen, vinblastin, methotrexate), which provides stable recovery in 81.3% of patients. Principal positions for management of DF are formulated.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1997

[Subtotal radical resection and primary reconstruction in breast cancer].

The authors present information on 44 patients with local breast carcinoma (Stages II and III) who were treated by a new type of operation in the form of radical subtotal resection of the breast and one-stage reconstruction without the use of endoprostheses. The authors describe some scientific and technical problems of the performance of these complicated surgical interventions. In future these operations may become operations of choice for a certain category of patients because they solve both therapeutic and rehabilitation problems.

Breast Neoplasms↗
PubMed1997

[Combined treatment of stomach neoplasms].

The results of treatment of 394 patients with gastric cancer were analysed to compare the effectiveness of surgical and two variants of combined treatment (preoperative irradiation with intensive-concentrated IKK method and dynamic DFD dose-fractioning). The advantages of combined treatment over surgical treatment are demonstrated. The 3-year survival in the combined treatment is 70.2%, in surgical treatment 34.5 +/- 6.2%. The advantages of SDF preoperative irradiation over IKK irradiation are revealed, that is proved by the increase of the 3-year survival rate (76 vs. 56.7%), and decrease in the rate of recurrence from 50 to 27.3%. The addition of metronidazol leads to increase of anticancer effectiveness, that is proved with the examination of tumor pathomorphosis and the rates of survival.

Adult↗
PubMed1996

[Autotransplantation of a double-bone-muscle-skin flap in the one-step segmental resection and plastic repair of distal segments of the extremities in cancer patients].

This article describes a biosteodermomuscular flap formation. The flap contains parts of VIII-IXribs, the broadest muscle of the back and a musculus serratus anterior. This method has been successfully used for a one-step segmental resection and microsurgical plastic operations on distal parts of extremities in five patients with malignant tumors of soft tissues.

Adult↗
PubMed1996

[Possibilities of preserving reproductive function after therapy for early malignancies of the cervix uteri, endometrium and ovaries].

Reproductive function was investigated in 155 females who had undergone organ-saving surgery for early forms of cervical carcinoma. Ninety-nine patients had their appendages unilaterally removed as part of therapy for ovarian malignancies, stage 1a. and 19 more who had received gestagen therapy for pre- and cancer of the endometrium. Menstrual function remained unimpaired in 99.3%. Changes in this function were observed postoperatively in 31 (20%) cases of cervical carcinoma. Paliative treatment for ovarian malignancies was followed by amenorrhea in 2 cases while changes in menstrual function-in 28 (28.3%). After hormone therapy those changes were registered in 11 (57.9%). One hundred and seven pregnancies in 75 (48.4%) patients were reported in group 1, 131 pregnancies in 72 (72.7%) -in group 2 and 16 pregnancies in 10 (52.6%) patients-in group 3. One hundred and thirteen babies were born after organ-saving surgery for early forms of cancer of the internal genitals perinatal mortality reaching 4.4%. Organ-saving therapy for early malignancies of the ovary, endometrium and cervix uteri has been found to be an effective means of treating the disease and maintaining certain specific functions of the female organism.

Adult↗
PubMed1995

[Clinical fluorescent diagnosis of tumors using photosensitizer photogem].

During clinical trials of photodynamic therapy (PDT) the tissue fluorescence spectra under 510 nm laser excitation were recorded in 22 patients with tumors of the lungs, larynx, skin, gastric and esophageal carcinoma, and cancer of the gynecological organs before (autofluorescence) and after drug administration. A spectroscopic fluorescence detection system, developed at the General Physics Institute, Russian Academy of Sciences, was applied for tumor diagnostics. The system has been used for clinical fluorescence diagnostics with the aid of HPD-type photosensitizer Photogem (Moscow Institute of High Chemical Technologies) marked by selective retention in malignant tumors. Methods and equipment for spectra analysis aimed at estimating drug distribution in the near-surface layers of tissues, determining the tumor boundaries before photodynamic treatment, as well as studying drug pharmaco kinetics have been developed and tested. The results demonstrate the possibility of tumor detection by fluorescence even in low selectivity of drug accumulation which appears to be dependent on the stage and type of the disease and the organ involved.

Female↗