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Biomedical subjects

V I Chissov

Publications and source records attributed to V I Chissov.

At least 91 records · Page 5Linked to original sources
PubMed1985

[Enhancement of the antitumor effect of cyclophosphane in an experiment].

A significant antitumor effect of acetylcellulose microsphere-encapsulated cyclophosphamide was observed in the course of the studies carried out in 105 male Wistar rats bearing Walker's carcinosarcoma and PC-1 carcinoma. The effect is due to a high tissue level of the drug maintained for a long time as the drug uniformly passes through the porous microsphere wall. Local (intratumoral) treatment with cyclophosphamide is more effective than standard methods. The inhibitory effect of microsphere-enclosed cyclophosphamide on neoplastic growth is potentiated by tumor ischemia.

Animals↗
PubMed1984

[Experimental study of the need for the dearterialization of tumors].

The influence of local ischaemia on the tumor growth rate and the character of metastases of Walker's carcinosarcoma-256 (WCS-256) and carcinoma RS-1 was studied in 168 male rats of Wistar line. The authors observed the dependence between the quantity of tumour cells in peripheral blood both under normal conditions and under local ischaemia in the tumour area. The efficiency of the produced ischaemia was controlled by the polarographic methods. The local ischaemia decreases grafting of tumours, reduces the growth rate and formation of the regional and distant metastases and decreases the quantity of the tumour cells in the peripheral blood.

Animals↗
PubMed1984

[Errors in diagnosis and treatment of stomach cancer].

An analysis of 51 cases of erroneous diagnosis and treatment of gastric cancer showed inadequate follow-up to cause advancement in 39 patients suffering from chronic lesions of the gastrointestinal tract. As a result of such superficial approach as well as insufficient oncological experience of general doctors, patients go through 2-6 examinations before diagnosis is established, this taking 5.8 +/- 1.4 months in rural, and 3.9 +/- 0.8 in urban areas. Failure to carry out intraoperative morphological verification of the diagnosis which results in unjustified extension of surgical intervention or, on the contrary, decision not to operate radically is the typical error involved in treatment of gastric cancer at general hospitals.

Adult↗
PubMed1983

[Preliminary results of a cooperative study of the efficacy of combined treatment of lung cancer].

The clinical data provided by the members of a CMEA joint study on the problem of Lung Cancer (Work group 3--9.1.1) are analysed. The study undertaken by the researchers of Bulgaria, Hungary, Poland, USSR and Czechoslovakia was concerned with evaluation of the effectiveness of a modality of combined treatment of well--differentiated cancer of the lung. The study group consisted of 286 patients; 231 surgically treated patients were in control. It was found that preoperative intensive concentrated radiation treatment did not interfere with surgical procedures. Nor did it specifically involve any intraoperative complications or change their frequency. However, combined treatment (preoperative irradiation + surgery) was followed by a relatively high mortality and a significant increase in the frequency of postoperative complications, especially purulent ones, such as bronchial fistula and empyema of the pleural cavity. Maximal difference in mortality rates between the groups was observed in cases of stage III cancer. The long-term results were studied in 379 cases (221 patients after combined treatment and 158--after surgery). 76.5 and 77.2, 49.4, and 41.2, and 34.4 and 20.7% of patients survived over one, three and five years, respectively. Better results registered in the study group were largely due to cases of stage III squamous cell carcinoma.

Adult↗