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Biomedical subjects

V I Komar

Publications and source records attributed to V I Komar.

At least 19 recordsLinked to original sources
PubMed1994

[Differential diagnosis of and diphtheria and tonsillitis].

Differential diagnostic differences have been analyzed for faucial diphtheria (41 patients), infectious mononucleosis (219 patients), follicular and lacunar tonsillitis (71 patients), Vincent tonsillitis (22 patients). Besides specific clinical manifestations, of special importance in distinguishing the above diseases was a profound analysis of hemogram with calculations of special parameters and variants of ESR/leukocyte count ratio.

Adult↗
PubMed1992

[Comparative effectiveness of various antibiotics in the treatment of patients with meningococcal meningitis].

The results of treating 322 patients with various forms of meningococcal infection accepted to a hospital within a year are presented. The patients were divided into 3 groups by the character of etiotropic therapy. The patients of group I were treated with benzylpenicillin and those of group 2 were treated with levomycetin sodium succinate. Group 3 included the patients, the therapy of whom with the above two antibiotics failed and they were subjected to treatment with cefazolin, cefotaxime, amikacin and other broad spectrum antibiotics. Benzylpenicillin generally proved to be the drug of choice in the antibacterial therapy of meningococcal infection. In comparison to levomycetin (chloramphenicol) it provide more rapid clinical recovery of the patients and normalization of the indices of the cerebrospinal fluid. Only failure of benzylpenicillin therapy was considered as an indication to the broad-spectrum antibiotics to be in the complex treatment of the patients. As additional methods for estimating the efficacy of antibacterial therapy it was recommended to employ calculation of the integral indices of hemograms (the leukocyte index of intoxication and the hematologic index of intoxication).

Adolescent↗
PubMed1992

[The use of water-soluble vitamins in viral hepatitis A].

To correct disbolism of vitamins C, B3, B6 and B12 due to viral hepatitis A (VHA), the patients received daily doses of the vitamins: 300 and 400 mg of ascorbic acid, 300 and 600 mg of calcium pantothenate or 90 and 180 mg of pantetin per os. 100 and 200 micrograms of cyanocobalamin alternating with 50 and 100 mg of pyridoxin was given intramuscularly every other day. The course lasted 3-4 weeks. The vitamin treatment promoted a positive trend in clinico-biochemical parameters, normalization of immunocompetent cell and serum immunoglobulins levels, of phagocytic reaction of peripheral blood neutrophils.

Antibody Formation↗
PubMed1991

[The blood level of cobalamin as an indicator of the functional status of the liver in jaundice of different etiologies].

Blood serum free vitamin B12, bilirubin, alanine aminotransferase levels were measured and thymol test made in 168 patients with viral hepatitis A, 13 with chronic hepatitis, 8 with mechanical jaundice of neoplastic origin, 7 with calculous cholecystitis, and 8 with functional hyperbilirubinemia by the microbiologic methods. Elevated blood serum levels of free vitamin B12, conforming to the disease severity and stage, were revealed in the patients with viral hepatitis A, chronic active hepatitis, and mechanical jaundice of a neoplastic origin with liver involvement. Correlations between cobalaminemia and other functional liver tests were observed. Therefore blood serum vitamin B12 measurements may be used for the assessment of the disease activity and severity of liver parenchyma injury.

Adolescent↗
PubMed1991

[The use of pantothenic acid preparations in treating patients with viral hepatitis A].

Calcium pantothemate in the daily dose 300 mg and 600 mg and pantetheine in the dose 90 mg and 180 mg per os were applied for 3-4 weeks in combined therapy of 156 patients with viral hepatitis A. In addition to the positive clinico-biochemical effect, these drugs produced an immunomodulatory action and a beneficial effect on the level of blood serum immunoglobulins and the phagocytic activity of peripheral blood neutrophils. Pantetheine provided the most pronounced therapeutic effect.

Administration, Oral↗
PubMed1989

[Humoral and cellular indices of nonspecific resistance in viral hepatitis A and ascorbic acid].

A total of 260 patients aged 15 to 57 years with virus hepatitis A were examined over time for some indicators of humoral and cellular immunity (serum IgA, IgM, IgG, the phagocytic number and indicator of the completeness of neutrophil phagocytosis, cytochemical content of ribonucleic and deoxyribonucleic acids in blood leukocytes). The immunological indicators were determined in two patients' groups after intake per os of 300 mg/day of ascorbic acid for 2-3 weeks and without its administration. It has been established that in virus hepatitis A, vitamin C exerts a remarkable immunomodulating action. In view of this fact, it should be necessarily included into multimodality treatment of patients suffering from pathology under consideration.

Adjuvants, Immunologic↗