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Biomedical subjects

V I Lebedev

Publications and source records attributed to V I Lebedev.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Antitumor antibiotics in the treatment of nephroblastomas in children].

The results of the chemotherapy of 20 children with nephroblastoma are analysed. The patients were treated according to the following scheme: vincristine in a dose of 0.05 mg kg bw once a week on the 1st, 8th, 15th and 22nd days, dactinomycin in a dose of 15 micrograms/kg once a day for 3 days on the 1st, 2nd and 3rd days of adriamycin in a dose of 30-40 mg/m2 on the 15th day of the treatment course. The postoperative chemotherapy was started 10 days after the operation. It was performed in 4 courses with intervals of 3 weeks. The efficacy of the treatment was estimated with angiography, echography and computer-aided tomography. The above scheme proved to be efficient in the treatment of the children with nephroblastoma. Reliable control of the tumor size during the preoperative treatment was shown to be possible.

Antibiotics, Antineoplastic↗
PubMed1982

[Problems of nephroblastoma in children].

An evaluation of 388 cases of Wilms tumor within 13 years established a high proportion of advanced cases among children: stage II - 30.6; III - 35.4; IV - 27.6 and V (bilateral) - 6.4%. Main homeostatic indices remained unchanged until stages III-IV. Primary tumor and metastases can be detected by a complex of clinical, X-ray and radioisotope methods the effectiveness of which is determined by degree of tumor extension. Dissemination of tumor at different sites were detected by primary examination in 40.5% and at later stages in 15% of patients. Most metastases (96%) were detected within the first 12 months of therapy. They were significantly more frequent at stage III and their frequency was in correlation with the patient's age at the time of tumor detection. Out of 388 cases, 112 (28.9%) survived for more than 3 years, stage II - 57.1; stage III - 25.4 and stage IV - 4.6% included. 1.5 - 2 year-long courses of pre- and postoperative polychemotherapy proved to be effective, whereas in cases of stage III tumor they should be supplemented with irradiation of primary tumor, its bed, regional lymph collectors and metastases. These measures ensured a 3-year survival in 69.5% of stage II patients and in 32.3% of stage III patients.

Child↗
PubMed1981

[1 of the variants of Wilms' tumor].

A peculiar variant of Wilms' tumor was studied. Out of 77 cases of nephroblastoma 2 observations were selected in which the tumor consisted of loosely arranged oval and polygonal cells with clear nuclei. Occasional formed tubules were found in the tumor. The cells had anastomosing processes, few organoids, microfibrils. A nonepithelial nature of the tumor is assumed. A trend for primary metastasis of the tumor into bones was observed. Because of the difficulties and rare occurrence of such tumors, their histology and differential criteria are presented at the light and ultrastructural levels. Indication of this variant in the diagnosis may also suggest the possibility of metastatic affection of the skeleton.

Biopsy↗
PubMed1976

[Makeup of the tubular structures of a stock culture of Act. roseoflavus var. roseofungini].

The methods of spectral analysis, spectrophotometry, fluorescence and thin-layer chromatography were used for the study of the composition of the tubular structures of the initial culture of Act. roseoflavus var. roseofungini. It was found that they contained a complex of antibiotics (roseofungin and its analogs), Ca, Mg, Na, K, Si and a significant amount of the third non-identified component in the antibiotic complex.

Circular Dichroism↗