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Biomedical subjects

V I Sachkov

Publications and source records attributed to V I Sachkov.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[Effect of delagil and hydrocortisone on specific lymphocyte blast transformation in vitro].

The effect of delagil (chloroquine) and of hydrocortisone taken in different concentration on the lymphocytes blast-transformation reaction in donors, stimulated with streptococcal nucleoprotein, was enquired into. Differences in the action of drugs on this reaction were uncovered, viz. delagil suppressed the specific stimulation of lymphocytes in all cases, both in therapeutic and toxic concentrations of it in the culture medium, whereas hydrocortisone inhibited the bacterial stimulation only in one half of instances and in the others--intensified it. The inhibitory effect of hydrocortisone gained in strength with its elevated concentration in the culture medium.

Cells, Cultured↗
PubMedDate not supplied

[Delayed hypersensitivity indices in dogs with an excessive protein content in the diet].

The state of an elevated delayed sensitivity was produced in dogs through intramuscular introduction of the human blood serum. Later on lymphocytes were isolated from the peripheral blood of the animals which were then tested by using a blast-transformation reaction and with reference to the lymphocite cytotoxicity. The ration containing an excess amount of protein was found to lower the activity of the lymphoid sensitized cells in the delayed type allergy during the said reactions.

Animals↗
PubMedDate not supplied

[Specific and nonspecific cytolysis reactions in rheumatic patients with a low degree of activity in the process of combined treatment by a high-protein diet and drug preparations].

Effect of therapy including high-protein diet and hormones on specific and nonspecific cytolysis was studied in patients with torpid and latent-running recurrent rheumatic carditis. The number of HeLa cells on which specific antigens (cardiac tissue extract, collagen, group C streptococcal nucleoproteid) were adsorbed significantly decreased on addition to the test target sensitized lymphocytes from the patients examined. As a result of therapy most patients showed the reduced activity of supernatants obtained from peripheral blood lymphocyte cultures that were incubated with specific antigens.

Adult↗