[A field experiment with neuraminidase influenza vaccine (author's transl)].
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Biomedical subjects
Publications and source records attributed to V Janout.
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The semi-quantitative ASAT screening examination has been used in groups of children over a period of 3 years for detection of VH cases. In these groups, 79% of VH cases, being mostly anicteric and clinically unapparent, were detected in the focus of infection in addition to the index cases. The application of this method resulted in a decrease by about one half in additional VH cases occurring in the focus after the detection of the index case. The semi-quantitative ASAT screening examination meets all general criteria required for a good screening method.
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During three expeditions undertaken in March 1977 to June 1978, 797 cloacal swabs were collected from birds of 54 species. Seven salmonella strains of six serotype were isolated from Larus ridibundus (five strains), Corvus frugilegus and Acrocephalus schoenobaenus (one each). Four strains of influenza A (HAV2 NA4V) virus were isolated from Larus ridibundus. For the first time in Czechoslovakia, two strains of Yucaipa paramyxovirus were isolated, both of them from Troglodytes troglodytes. These results are the first contribution to a study on the role of birds as hosts and vectors of different bacterial and viral agents.
In 1977, 477 small birds of 52 species were virologically examined. Five cloacal swabs from Troglodytes troglodytes yielded two paramyxovirus strains which were found antigenically related to, but not identical with Ch/Yucaipa/California/56 virus according to three serological tests. The ecological significance of these findings and the possibility of paramyxovirus classification into four types are discussed.
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The immunological potency of a subunit influenza vaccine (from A/England/42/72 virus) and of two commercial whole-virus vaccines (containing either A/England/42/72 or A/Hong Kong/68 virus) was studied in adults in an industrial plant. Serum samples were taken in vaccinated and control non-vaccinated subjects prior to and three weeks and five months after the vaccination. Most of the vaccinees developed high levels of hamagglutination inhibiting antibodies against all the type A influenza viruses employed in the test; these antigens included a new strain (A/Dunedin/73) that had not previously circulated in Czechoslovakia. The antibody response after the subunit vaccine was somewhat better than after the whole-virus vaccines administration. The whole-virus vaccine from the A/England/42/72 virus was more efficient in inducing antibody response against the more recent isolates than the A/Hong Kong/68 virus vaccine.
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