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Biomedical subjects

V K Kozlov

Publications and source records attributed to V K Kozlov.

At least 37 records · Page 2Linked to original sources
PubMed1978

[Beta-adrenoreceptors on the surface membranes of lymphocytes and macrophages].

In experiments in vivo and in vitro on sensitized and intact guinea pigs and Wistar rats the effect of beta-adrenergic stimulants (adrenaline and izoproterenol) and a beta-adrenergic blocker (propranalol) on lymphocytolysis and the reaction of macrophage adherence inhibition was studied. Adrenaline and izoproterenol were shown to inhibit the antigen interaction with both sensitized and intact cells. Restoring the sensitivity of cells to the antigen, propranalol destroys the defensive action of adrenaline and isoproterenol.

Animals↗
PubMed1978

[Structural-functional organization of hemostatic clots].

The studies were carried out to verify the hypothesis on the structural-functional organization of the hemostatic clot. For this purpose the influence of the platelets and their aggregate condition on the mechanical properties of the clot was investigated. Redistribution of platelets into aggregated, caused by addition of ADP and mixing, led to the inhibition of the clot retraction. This was reflected in the form of reduction of am on the thromboelastogram. Simultaneous recording of thrombloelastogram, coagulbbogram, and platelet degranulation demonstrated that processes of viscid metamorphosis of platelets and fibrin filaments sedimentation were followed by active clot contraction. The clot is a fibrin-platelet structure whose nodes contain blood platelets, and cells--the rest blood elements. The clot retraction takes place due to contractile properties of platelets.

Adenosine Diphosphate↗
PubMed1977

[Blood coagulation upon contact between blood and polymeric materials possessing electretic protperties].

Hemocoagulation peculiarities were studied on polymeric materials with the electretic properties. Negative polarity of the electretic polymeres promoted fibrinogenemia and hypoadhesia of platelets in comparison with the electretic materials with positive polarity and polymeres possessing no static electricity. It is supposed that fibrin sorption and platelet hyperadhesion played the main role in thrombogenesis on implanted polymeres.

Blood Coagulation↗
PubMed1975

[Lysosome-like alpha-granules of thrombocytes: detection by acridine orange treatment, properties and transformations during the course of blood coagulation reactions].

Using the ability of lysosome-like alpha-granules of thrombocytes to accumulate flurochrome acridine orange, their transformation kinetics was studied in the course of cell viscous metamorphosis utilizing the fluorometric technique. It turned out that during the thrombin induced cellular viscous metamorphosis lysosomes released their contents: the process is stimulated by the presence of extracellular Ca2+. Competitive relations were revealed between the accumulation within cytoplasmic granules of thrombocytes of acridine orange and serotonin, and that of histamine and novocaine. The process of fluorochrome accumulation was found to be temperature dependent and to be inhibited by monoiodacetate.

Acridines↗
PubMedDate not supplied

[Etiology, clinical manifestations, and epidemiology in community-acquired respiratory infection in children in the Khabarovsk region].

Clinico-epidemiological analysis and etiological verification of the outbreak of respiratory infection among school children in a rural district of the Khabarovsk territory, registered in spring 1997, were made. According to clinical signs, one-third of the patients had whooping cough, while the rest of the children exhibited the signs of respiratory infection with the symptoms of longering bronchitis. A half of the children had not been vaccinated against whooping cough, as they had been given injections of adsorbed DT vaccine with reduced antigen content. Etiologically, the diagnosis of whooping cough was confirmed in 57% of the patients with 47.4% of them having Bordetella pertussis monoinfection and 52.6% having mixed infection, mainly in combination with chlamydiosis. Whooping cough took an abnormal course under these circumstances. Treatment with erythromycin produced a good effect.

Adolescent↗
PubMedDate not supplied

[Ways and means for prolonging the action of drugs (the status of the problem and the outlook)].

The modern approaches and concrete variants of the up-to-date means of prolongation of the biological effects of medicinal compounds having high tropic target-structures in the organism (pharmacodynamic drugs) are summarized. According to the principles of the influence on biodistribution, pharmacodynamics and metabolism of drugs, three main methods of prolongation: (technological (pharmaceutical), chemical and physiological are distinguished. The expediency of distinguishing a new method of prolongation--immunological is grounded. During the use of the method a drug in the complex with specific immunoglobulins of certain serological characteristics is a reversible depot-form of the preparation under in vivo conditions that provides the effect of prolongation.

Chemical Phenomena↗
PubMedDate not supplied

[The periodic and regional characteristics of the pneumococcal serotype spectrum in children with respiratory diseases and in healthy carriers].

The aim of the work was the comparative study Streptococcus pneumoniae serotypes, isolated from healthy carriers and acute pneumonia patients in different regions of the CIS; in Moscow observations were carried out for 10 years. Specific antibodies to different S.pneumoniae capsular polysaccharide antigens were determined in blood serum samples by the method of heterogeneous enzyme immunoassay. The study revealed that S.pneumoniae serotype spectra in healthy children and in children with acute respiratory viral diseases were similar, while from pneumonia patients with complications of pleuritis caused by S.pneumoniae serotypes 1, 3, 5 and 14, were more frequently isolated. During 10 years of observations changes in the occurrence of individual serotypes were noted both in carriers and in patients. Differences in the serotype spectra of S.pneumoniae isolated in different regions were established. S.pneumoniae serotype 5 caused 70% of pleuritis cases in Tashkent, while rarely occurring in regions with the moderate climate. S.pneumoniae serotype 14, formerly causing complicated forms of pneumonia, lately became more widespread, but at the same time caused fewer cases of pneumonia with complications. High occurrence of pneumonia among children aged 1-3 years correlated with a low level of specific antibodies in the child population.

Antibodies, Bacterial↗