Biomedical subjects
Publications and source records attributed to V L Valetskiĭ.
Experience of diagnosis and treatment of primarily-multiple gastric cancer, combined with malignant colonic tumors in 27 patients was summarized. One-stage combined radical treatment of the patients is the most effective one.
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The results of the analysis of diagnosis of acute pancreatitis on the basis of studying 3634 case records are presented. Errors in the diagnosis of acute pancreatitis at the prehospital stage were established in 61.9%, at the early hospital stage--in 32.35% of cases, usually in the form of hyperdiagnosis of the disease.
In 92 patients with acute pancreatitis, the informative value of the available methods for laboratory investigations (general blood analysis, biochemical blood analysis with measurement of the level of total protein, bilirubin, glucose, ALAT, ASAT, amylase activity, amylase activity in the urine) was analysed. The authors consider that the indices studied are rather informative for independent reliable diagnosis of acute pancreatitis and differentiation of its forms.
The relationship between the pregnancy specific proteins (SP1, SP3) and the functional activity of ConA-induced T-suppressors has been studied during normal gestation. There were a positive correlation between the activity of T-suppressors and the level of SP1 during 8-28 weeks of gestation; between the activity of T-suppressors and the level of SP3 during 8-36 weeks, especially during 29-36 weeks of gestation. It was shown that a progressive accumulation of these proteins apparently necessary for the formation a suppression's dominant in the condition of the immunoregulatory branches during gestation. These findings suggest that SP1 and SP3 as a natural endogenous immunoregulators may play an important role in reproductive strategy of human gestation.
The levels of T gamma- and T mu-lymphocytes, functional activity of ConA-induced T-suppressors and the concentrations of SP1 and SP3 were determined in 164 normal pregnant women during 8-40 weeks of gestation. It is found that formation of the suppressor dominant is necessary for the immunological maintenance during 8-32 weeks of gestation. This dominant is intended to block superfluous maternal immune response to fetal alloantigens. The formation of such a dominant is evoked by high functional activity of ConA-induced T-suppressors and high levels of T gamma-lymphocytes with immunodeficiency of T mu-cells. Results of correlation analysis have shown a relationship between functional activity of T-suppressors and accumulation of two specific pregnancy proteins. It permits determining physiological role of SP1 and SP3 as natural endogenous immunoregulators of T-suppressors.
Preoperative intraarterial chemotherapy was administered to 69 patients with gastric cancer. In 34 patients the tumor was localized in the antral portion, in 27 in the body of the stomach involving the proximal portion, and in 8 total involvement of the stomach was revealed. Left gastric artery was catheterized in 42 patients, right gastric-omental artery in 27. An original method of "loop" catheterization of celiac artery branches was used permitting a selective probing of gastric arteries proper. For prolonged intraarterial chemotherapy of gastric cancer adriablastin or farmorubicin were used in single dose 30 mg/M2, 5-fluorouracil in dose 500 mg/M2; the cytostatics were infused in 2-3 sessions. Immediate results of intraarterial chemotherapy were assessed by angiography and other instrumental methods of investigation, as well as intraoperatively and by morphometric analysis. In 62.4% of patients significant or total destruction of the tumor was attained, the volumic share of a viable tumor component being 0 to 2.1%. Altogether 95% of patients survived the follow-up of 2 to 30 months.