[Immunologic status in physiological pregnancy].

V P Chernyshov; V L Valetskiĭ; T V Radysh

PubMed · 2531686

[Immunologic status in physiological pregnancy].

Abstract

The levels of T gamma- and T mu-lymphocytes, functional activity of ConA-induced T-suppressors and the concentrations of SP1 and SP3 were determined in 164 normal pregnant women during 8-40 weeks of gestation. It is found that formation of the suppressor dominant is necessary for the immunological maintenance during 8-32 weeks of gestation. This dominant is intended to block superfluous maternal immune response to fetal alloantigens. The formation of such a dominant is evoked by high functional activity of ConA-induced T-suppressors and high levels of T gamma-lymphocytes with immunodeficiency of T mu-cells. Results of correlation analysis have shown a relationship between functional activity of T-suppressors and accumulation of two specific pregnancy proteins. It permits determining physiological role of SP1 and SP3 as natural endogenous immunoregulators of T-suppressors.

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Female Humans Immune Tolerance Leukocyte Count Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second Pregnancy Trimester, Third T-Lymphocytes, Helper-Inducer T-Lymphocytes, Regulatory Comparative Study English Abstract Journal Article

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V P Chernyshov, V L Valetskiĭ, T V Radysh. [Immunologic status in physiological pregnancy].. https://pubmed.ncbi.nlm.nih.gov/2531686/

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