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Biomedical subjects

V M Dilman

Publications and source records attributed to V M Dilman.

At least 37 records · Page 2Linked to original sources
PubMed1979

Increase in lifespan of rats following polypeptide pineal extract treatment.

The 20 month-long treatment of female rats with daily doses of 0.1 or 0.5 mg of polypeptide pineal extract (PPE) per animal increased their lifespan by 10 and 25%, respectively, as compared with controls. At the age of 16--18 months, 38% of control rats exhibited persistent disturbances in estral function (constant estrus or repeated pseudogestations), whereas these disorders were observed in 7% of experimental animals only. After administration of PPE to 16--18 month-old female rats checked for sterility by a two-week mating, a second mating period resulted in gestation development in four out of 16 animals and deliveries, accordingly. While chronic treatment with PPE did not affect the rate of neoplasm incidence, the mean age of tumour detection in the control group was 697 days and in experimental groups it was 811 and 868 days, respectively. Certain aspects of the interrelationship of rate of ageing, lifespan and specific age pathology are discussed.

Animals↗
PubMed1979

Potentiation of antitumor effect of cyclophosphamide and hydrazine sulfate by treatment with the antidiabetic agent, 1-phenylethylbiguanide (phenformin).

It was shown that 1-phenylethylbiguanide (phenformin) administered orally to mice at a dose of 2 mg/day potentiated the antitumor effect of cyclophosphamide on transplantable squamous cell cervical carcinoma, hepatoma-22a and Lewis lung tumor, but did not alter the effect of cyclophosphamide on sarcoma-180 and L-1210. Oral administration of phenformin (5 mg/day) to rats with transplanted Walker 256 carcinoma enhanced the antitumor effect of hydrazine sulfate.

Animals↗
PubMed1979

Study of the anti-tumor effect of polypeptide pineal extract.

Bovine pineal polypeptide extract (PPE) exerted an anti-tumor effect on mouse-transplantable tumors: mammary cancer (RSM), squamous cell cervical carcinoma (SCC), hepatoma-22a and lympholeukemia LIO-1, and had no effect on Harding-Passey melanoma and leukemia L-1210. It was shown that PPE possessed the ability to decrease the incidence of DMBA-induced mammary adenocarcinomas in rats. The daily administration of 0.5 mg PPE prolonged the life span of rats by 25% and failed to influence spontaneous tumor development. The arguments in favor of a possible mechanism of anti-tumor action of the pineal gland are submitted. It is suggested that the anti-tumor effect of PPE may occur when the syndrome of cancrophilia is induced by tumor transplantation or chemical carcinogens.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1978

Effect of parathyroid hormone and insulin on extracellular cyclic adenosine-3',5'-monophosphate in patients with benign and malignant breast tumors.

Basal excretion of cyclic adenosine monophosphate (cAMP) and its basal level in blood plasma in breast cancer (BC) patients and those with fibroadenomatosis did not differ essentially. However, intravenous injection of parathyroid hormone (100 U) and insulin (0.08 U/kg body weight) was followed by a much less rise in urine-cAMP excretion and blood-cAMP levels in BC patients than in benign process in mammary gland. A substantial correlation between changes in plasma cAMP level and the degree of insulin-induced hypoglycemia was not observed. There was a negative correlation between reponse to parathyroid hormone and insulin and body overweight in BC patients. It was suggested that body fat content may influence the peculiarities of metabolism of extracellular cAMP in cancer patients considerably.

Adipose Tissue↗
PubMed1978

Inhibition of DMBA-induced carcinogenesis by phenformin in the mammary gland of rats.

It is shown that daily oral administration of 5--10 mg of an antidiabetic biguanide-phenformin (phenethyl-biguanide) for 2.5--5 months suppressed DMBA-induced mammary tumour development in rats considerably. Phenformin-treated rats revealed-a tendency towards a decrease in blood insulin level (radioimmunoassay). The obtained data are regarded as additional evidence for the proposed existence of the same metabolic background of diseases of compensation, i.e. adult-onset diabetes, artherosclerosis and cancer, and suggest studies on possible antitumour effect of phenformin in man.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1977

Metabolic immunodepression which increases the risk of cancer.

When some metabolic changes occur--namely, when blood levels of free fatty acids (F.F.A.), insulin, cholesterol, or triglycerides rise--cellular immunity becomes depressed. These metabolic changes also promote the division of somatic, non-lymphoid cells, which in turn increases the possibility of malignant transformation. The diametrically opposite effects of these metabolic changes on non-lymphoid cells, on the one hand, and on T-dependent lymphocytes and macrophages on the other, increase an individual's susceptibility to cancer. This normally occurs with pregnancy, rapid growth, stress, and ageing. Many chemical carcinogens raise the hypothalamic threshold to feedback control mechanisms, decrease glucose tolerance, and increase blood-insulin--i.e., all the main changes of "cancer-proneness". Changes in biogenic amine level in the hypothalamus during ageing and stress and after an exposure to some carcinogens are responsible for the elevation of hypothalamic threshold to feedback control.

Age Factors↗
PubMed1977

Endocrine-metabolic criteria for distinguishing two pathogenetic types of breast cancer.

Hypothalamic threshold of sensitivity to homeostatic inhibition was studied by means of the dexamethasone test of inhibiting excretion of steroid hormones in 47 patients with the primary breast cancer of different age groups. Before the dexamethasone test and after it, blood specimens were taken for the following tests: daily variation of blood sugar or sensitivity to insulin action, cholesterol, lipoproteins, phospholipids, uric acid, growth hormone and insuline levels, and level of corticosteroids. On the base of the results obtained all the patients could be divided into two groups: 1. patients with signs of elevated threshold of hypothalamic sensitivity to inhibition and 2. patients without such signs. The breast cancer developing against the background of endocrine metabolic disturbances characteristic of advanced age is on the whole prognostically more favorable than tumors in women who have no disturbances of that kind. However, metabolic shifts characteristic of ageing obviously play an important role in creating a background that promotes higher incidence of mammary cancer in elderly subjects.

Adult↗
PubMed1976

On the relationship between the activity of acetylation, growth of experimental tumors and efficacy of their suppression by hydrazine sulphate.

The growth of experimental tumors was found to involve an intensification of acetylation of sulphadimidine. Inhibition of carcinosarcoma Walker-256 by 88% and sarcoma-180 by 36% on treatment with 60 mg/kg body weight of hydrazine sulphate was followed by decreases in the rate of acetylation of 39.4 and 29.4%, respectively. When treatment failed to suppress tumor growth (sarcoma-45), acetylation level showed no decrease. The results point to a correlation between growth of tumors and their inhibition on the one hand and the level of acetylation on the other.

Acetylation↗