Biomedical subjects
Publications and source records attributed to V M Frolov.
Clinical and immunological variants were assessed in 62 patients with toxic drug hepatitis due to tuberculostatic therapy. Three clinicoimmunological variants of toxic hepatitis were recognized. They need to be accounted for when deciding on immunocorrection.
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Prospects for the correction of disturbances in the macrophagal system with a combination of lysozyme and vitamin E in patients with a protracted course of dysentery caused by Shigella flexneri 1b were studied. The phagocytic activity of macrophages (PAM) was found to be suppressed as early as at the beginning of the disease. Out of 38 persons repeatedly found to release shigellae 24 were administered polychemotherapy. PAM indices in patients treated with lysozyme and tocopherol acetate were likely to normalize, this being indicative of the positive effect of these preparations on the functional activity of the macrophagal system.
As many as 111 patients with multiple sclerosis were subjected to clinical and functional examinations twice: on admission to the hospital and after immunocorrective therapy. The patients were discovered to have alterations in cellular immunity. During exacerbation, there was a decline of suppressors and a rise of the content of B lymphocytes. The immunocorrective therapy led to immunodeficiency stabilization.
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The follow-up involved patients with infiltrative pulmonary tuberculosis who developed toxic medicamentous hepatitis associated with antituberculosis drugs. They were treated by the method of combined pharmacotherapy which comprised sodium nucleinate (0.5 g 4 times daily), splenin (2 ml twice a day) and quercetin. The given combination of drugs rapidly improved clinical parameters and normalized immunologic tests.
The immune status was investigated in 97 patients with multiple sclerosis. Patients of this group showed marked changes at the cellular lever of the immune system. T-lymphocytopenia was accompanied by a dysbalance of the main correlative cells according to a relatively hyposuppressor variant of immune deficit with formation of circulating immune complexes and thermodependent lymphocytotoxic autoantibodies.
The clinical efficacy of a vilozen and ketotifen (zaditen) combination in the treatment of streptococcal infections along with the routine therapy was studied. The use of the combination was shown advisable in the complex therapy and prevention of relapses in patients with streptococcal infections. The combined pharmacotherapy promoted better clinical indices, normalization of the immune status and a reduction in the incidence of allergic reactions to antibiotics and a decrease in sensitization to bacterial allergens.
Inclusion of tocopherol acetate and splenin into complex treatment of viral hepatitis B (VHB) ensures a marked immunomodulating effect consisting in control of T-lymphopenia, normalization of helper-suppressor ratio, reduction of circulating immune complexes and a tendency to restoration of normal ratio between separate fractions of immune complexes, stimulation of phagocytic activity of monocytes of the peripheral blood. Splenin and tocopherol acetate are recommended in the complex treatment of hepatitis B.
It was established that administration of S. typhimurium lysate causes activation of the processes of free-radical oxidation. Introduction of unithiol in combination with magnesium sulfate returns the intensity of these processes to the initial level. Unithiol and alpha-tocopherol acetate protect the animals form lethal effects of S. sonnei lysate. Use of a combination of pharmacological agents consisting of unithiol, magnesium sulfate and alpha-tocopherol acetate in the treatment of patients with acute intestinal infections due to gram-negative pathogens (shigellae, salmonellae, proteus, klebsiellae, pseudomonas) resulted in decrease of the length of the intoxication and diarrhea syndrome, decrease of the frequency of repeat bacteria elimination and protracted forms of these infections, more rapid normalization of immune system functions.
A total of 192 patients with Flexner's dysentery 1 have been examined. As a result, sharply pronounced unbalance of cell-mediated and humoral immunity factors has developed in the acute period of dysentery, reaching its maximal manifestations in severe course of the disease. In case of a tendency to a prolonged course of dysentery at the period of convalescence, essential shifts in immunological characteristics persist and the infective agent is repeatedly isolated.
Immunological indices were compared in 138 patients with angina and concomitant bronchitis; 86 of them received antibiotics, splenin and vylosen; 52 received routine treatment. It was established that use of a combination of splenin and vylosen produces a pronounced immunodulating effect in primary immunodeficiency states due to recurrences of angina and concomitant pathology of the bronchopulmonary in workers of a large industrial enterprise. Immunomodulators are indicated in the treatment of repeat and relapsing angina, especially in the presence of concomitant bronchitis.
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Hepatobiliary function and immune status were evaluated in 92 pregnant women who had had viral hepatitis A (group 1) and in 35 who had suffered from viral hepatitis B. A control group included 102 healthy pregnant women. In group 1 there appeared clinical symptoms suggesting impairment of hepatobiliary system. It is suggested that pregnant women with the history of hepatitis should consult specialist on infections or gastroenterologist to specify the pathological process in order to correct it adequately.
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The clinical efficacy of sodium nucleinate (SN) combined with splenin and quercetin given for lingering Flexner's dysentery in a group of 43 patients was compared with that of routine therapy used in a group of the same number of patients. It has been established that the above drug combination favours the elimination of the pathological symptoms of dyspepsia, the arrest of bacterial isolation and normalization of the immune status. Provided the effect of the combined drug treatment is insufficient, the method of choice is the administration of gene engineering alpha 2-interferon (reaferon) in combination with tocopherol acetate and rectal suppositories containing methyluracil.
Examinations of 56 pregnant women with cholestatic hepatosis have demonstrated the clinical distinctions of this condition from viral hepatitides. The detected immunity status shifts indicated the suppressor cell immunodeficiency variant.