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V M Gindilis

Publications and source records attributed to V M Gindilis.

44 records · Page 3Linked to original sources
PubMedDate not supplied

[In situ hybridization in human genome mapping].

The methodological possibilities of non-radioactive in situ hybridization of nucleic acids and its application for an immediate localization of genes and chromosomes are discussed. The advantages of a non-isotope probe labeling versus a use of radioactive substances are emphasized. Various types of compounds used as a label are distinguished. The principles of use of the above labels and the ways to improve the method in terms of increasing its sensitivity are considered. Some results obtained while using non-radioactive labelled probes are reported. It is shown promising to use this method for molecular-genetic analysis of DNA polymorphism in human genome.

Chromosome Mapping↗
PubMedDate not supplied

[Concordance in twins and the component partition of phenotypic variance in schizophrenia].

The paper deals with a study of the pairwise and proband concordance rates to schizophrenia in 36 monozygotic (MZ) and 87 dizygotic (DZ) twins. Pairwise concordance rate to manifestative forms of schizophrenia was 0.54 and 0.18 for MZ and DZ twins, respectively, but when broader diagnostic criteria were used, the values were 0.73 and 0.27. Proband concordance rate in MZ twins was 0.70. The results of component partition of phenotypic variance show a leading role of a genotypic additive component in the development of schizophrenia (56.1%) and significance of the specific twin paratypic component. A conclusion is made on the leading role of genotypic factors in schizophrenia.

Diseases in Twins↗