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Biomedical subjects

V M Ivanov

Publications and source records attributed to V M Ivanov.

At least 19 recordsLinked to original sources
PubMed2005

[Changes of activity of the endothelial system in experimental heart failure].

Despite obvious participation of endothelins in pathogenesis of heart failure therapeutic approaches to the use of endothelin receptor antagonists remain to be elucidated. Experimental heart failure caused by prolonged infusion of norepinephrine is associated with diminished endothelin induced coronary constricting effect of stimulation of ET(A) receptors and inversion of coronary dilating effect of stimulation of these receptors. The latter effect is mediated by smooth muscle ET(B)-receptors and is indicative of functional derangement of vascular control by endothelial cells. The use of selective ET(A)-antagonist is effective on early stages of heart failure while on later stages administration of nonselective ET(AB)-antagonist produces more pronounced effect.

Animals↗
PubMed2003

[Immunity in patients with active tuberculous spondylitis].

Immunological parameters were studied in 45 patients with active tuberculous spondylitis, admitted for surgical treatment, who were divided into 2 groups in accordance with the prevalence of exudative-necrotic, or productive components of inflammation in the vertebral bodies and paravertebral tissues. The patients with a predominantly exudative-necrotic component of inflammation exhibited a severe clinical course with frequent neurological disorders, large abscesses in the paravertebral tissues, inflammatory changes in the leukogram, enhanced specific T-lymphocytic activity in the PPD blast-transformation reaction, significant increases in the levels of tuberculosis antibodies and IgE, IL-2 and it soluble IL-2 receptor RR-alpha, an excessively high increase in the functional activity of neutrophilic granulocytes, and lower with IgG2. The degree of immunological disorders corresponds to the severity of a course of tuberculous spondylitis.

Adolescent↗
PubMed2003

[Clinical and laboratory features in tuberculosis and osteomyelitis of the spine].

Tuberculous spondylitis runs atypically with its acute onset, high fever, and violent pain in 20% of cases. This disease is characterized by a high specific activity of T lymphocytes, by high levels of antituberculous antibodies, by a higher activity of adenosine deaminase, by higher concentrations of IgA and IgE. The gradual onset and few-symptom course of hematogenous osteomyelitis were revealed in 15% of cases. In osteomyelitis, there was a low concentration of antituberculous antibodies, higher levels of low and medium molecular mass, and IgG.

Adenosine Deaminase↗
PubMed2001

Direct determination of traces of beryllium with eriochrome cyanine R by diffuse reflection spectroscopy using chromaticity functions.

Chromaton-N-super and Silasorb C18 (SMT C18) were compared as solid supports for the direct determination of the immobilized beryllium complexes with eriochrome cyanine R by diffuse reflection spectroscopy. The advantage of Silasorb C18 was shown. A detection limit of 0.0002 microg mL(-1) could be reached in a 100-mL sample. The method was used for the analysis of real water samples.

Benzenesulfonates↗
PubMed2000

Improvement of direct determination of trace nickel in environmental samples by diffuse reflection spectroscopy using chromaticity characteristics.

Cellulose and chromaton-N-super as solid supports for direct determination of the immobilized nickel complexes with dimethylglyoxime and benzyldioxime by diffuse reflection spectroscopy were compared. The advantage of chromaton-N-super with use of benzyldioxime is shown. Detection limit is 0.02 microg/mL. The proposed method was applied for the analysis of soil.

Indicators and Reagents↗
PubMed2000

[Conservative therapy for early-stage breast cancer].

An evaluation of the data on the treatment of 298 cases of breast cancer (stages IIa and IIb) showed that a reduced frequency of loco-regional recurrences, after post-operative irradiation as a component of conservative therapy, was followed by improvement in quality of life. This was particularly apparent in patients with pT2pN1 tumors. It was also found that after extended dissection of axillary lymph nodes at all three levels, a dose of 50 Gy was sufficient without additional irradiation of the cicatrix. Nor was it necessary to expose the axillary area in cases of three or less lymph node recurrences provided that at least 6 resected nodes were studied histologically. Following conservative therapy, 5-year survival was 97%, while relapse-free survival--82%.

Adult↗
PubMed1997

[Structure of nutrition of one of Moscow's districts and its relationship to risk factors of chronic noninfectious diseases from the standpoint of medical prevention].

Dietary intake was studied in 295 of Moscow's residents by 24-hour recall method. High level of animal fat, sugar and cholesterol (Ch) were found in diet of man and women. Energy intake of men is higher than that of women at the expense of animal fat and protein. Women consume less amount of cholesterol-containing food. The levels of serum Ch, HDLP-Ch, triglycerides are in close relation with blood pressure values. The levels of serum Ch, HDLP-Ch, systolic and diastolic blood pressure are connected with variables of age and body mass index.

Adult↗
PubMed1994

[A comparative evaluation of 2 physical loading tests in arterial hypertension].

Interrelationships between arterial pressure (AP), physical performance (PP) and arterial hypertension (AH) risk factors were studied in two representative samples of hypertensive subjects using multivariate stepwise regression analysis in the preexercise, exercise and postexercise periods and two exercise tests. Test 1 (standard continuous bicycle ergometry) allowed PP estimation by the work performed and double product (HRmax x SAP/100 max). Test 2 (stepwise intermittent bicycle ergometry by PWCx) estimated PP according to a special formula. Test 1 is standard and therefore is able to provide significant diagnostic, prognostic and rehabilitation information. Test 2 is standard only at its first step, while the second step varies with cardiovascular response to the initial step. This is convenient for definition of permissible exercise dynamic control over exercising subjects, assessment of training efficacy in different regimens and programs. It is concluded that both methods are fit for estimating relations between AP, PP and AH risk factors in exercise and are comparable by the main parameters.

Adult↗
PubMed1993

[Arterial pressure, physical activity and physical work capacity].

A representative population sample was studied to elucidate relationships of arterial pressure (AR) with muscular performance (MP) and arterial hypertension risk factors. Power working capacity (PWCx) was measured by means of exercise tolerance test at rest, under physical loading and after the exercise. The findings were processed using a multivariate step-by-step regression analysis which established independent relations between exercise and postexercise MP and arterial hypertension. In normal and hypertensive males a rise in systolic pressure (SP) after the initial exercise (load 1) was dependent on PWC1 after more intensive exercise (load 2) on relations of MP with heart rate, SP and diastolic pressure (DP). In hypertensive males the SP elevation depended also on the age, B. W. index and heart rate. In normal AP males a DP rise depended on PWC2 and MP, the increment being limited by relationships between MP, DP, heart rate and SP. In hypertensive males the influence of PWC1 is defined through a SP rise after load 1. In normal AP and hypertensive females PWC1 is decisive for a SP rise. In normal AP females growth of DP after load 2 was dependent on PWC2 in relation to heart rate growth after load 2, while in hypertensive females PWC1 resulted in DP elevation after load 1. On comparison of the groups with normal and high AP the degree of AP increment under exercise depended on the relations of MP with heart rate, SP and DP.

Adult↗
PubMed1990

[The determination of free and bound oxyproline in urine].

A method of measuring urinary free, peptide- and protein-bound hydroxyproline is suggested. Adults were found to excrete 18 mumol of free, 155 mumol of peptide-bound, and 8 mumol of protein-bound hydroxyproline daily. In children daily urinary levels of free and peptide-bound hydroxyproline were higher. Data are presented on changes in various hydroxyproline forms in pneumonia, rheumatic fever, and hemorrhagic fever with the renal syndrome.

Adult↗
PubMed1989

[Tobacco smoking and various measures to control it].

The prevalence of smoking has been studied in a population of a Moscow district. The data obtained evidence that 49.0-54.6% of men and 9.2-13.5% of women, aged 20-59, smoke. Smoking was most common at the age of 20-39 (62.6 and 19.0% for males and females, respectively). Regular smoking was registered in 14.4-53.3% of schoolboys and 0.8-28.2% of schoolgirls (pupils of forms 5-10), the habituation being dependent on the number of smoking relatives. A 5-year prospective investigation of 40-59-year-old males allowed the conclusion on high mortality rate among heavy smokers: a three-fold difference for all reasons and cancer, and 2.5-fold difference for cardiovascular diseases compared to respective mortality in non-smokers. A special age-adjusted program designed for smoking control in schoolchildren produced positive 3-year results: a decrease from 17 to 5.9% in smoking incidence among boys of forms 5-7, from 42.1 to 20.7% for boys and from 9.6 to 6% for girls of higher forms. A pilot experience gained in a special office organized for those willing to give up smoking is presented. The treatment involved acupuncture, chemotherapy and psychotherapy.

Adolescent↗
PubMed1989

[Integral approach to the prevention of major chronic non-infectious diseases].

The essence and the necessity of an integral approach to prevention of major chronic noncommunicable diseases (CNCD) is described proceeding from the example of the integral CNCD prevention programme in one of Moscow districts. The aims and basic directions of preventive activities are demonstrated along with possible ways of integrating medical services with various district nonmedical institutions. The findings of the sample study of the adult population (25-64 years) of the district are provided. The study has been carried out prior to the preventive activities and touched upon information supply of the population in relation to healthy mode of life, prevalence of major risk factors (arterial hypertension, smoking, excessive body weight, hypercholesterolemia) and some CNCD (IHD, chronic bronchitis, diabetes mellitus).

Adult↗