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Biomedical subjects

V M Tkachenko

Publications and source records attributed to V M Tkachenko.

32 records · Page 2Linked to original sources
PubMed1984

[Myocardial function in the period immediately after aortocoronary bypass].

Thirty patients with coronary heart disease were examined before and then 1.5 +/- 0.2 months after the operation of aortocoronary shunting. A total of 68% of the shunts proved patent. All patients were divided into 3 groups: group 1-14 (47%) patients with patent shunts, group 3-12 (40%) patients with partially patent shunts, group 3-4 (12%) patients with occluded shunts. The patients of the first two groups showed no changes in either the segmentary contractility of the left ventricular wall or in the time-course of the ejection fraction and left ventricular volumes. The patients of group 3 demonstrated the deterioration of both hemodynamic indices and parameters characterizing the segmentary contractility of the left ventricular wall which was caused by thrombosis of the aortocoronary shunt resulting in the development of ischemia or myocardial infarction in the zone of the shunted coronary artery.

Adult↗
PubMed1984

[Relations between the myocardial state and several indicators of the myocardial function of the left ventricle in patients with ischemic heart disease].

Forty-six patients aged 39 to 59 years with coronary heart disease were examined. The control group comprised 10 healthy men. The myocardial injury was evaluated according to the ECG data. All the patients were subjected to selective coronarography and left roentgenokinoventriculography. To appraise the left ventricle myocardial contractility, the following indicators were made use of: the end diastolic pressure, ejection and the ratio of the peak systolic pressure in the left ventricle to the end systolic volume relative to the body surface. During kinoventriculography, left ventricle asynergy was detected in 65.2% of cases, whereas the reduction in the magnitudes of ejection and in the Ppeak/ESV X m2 index in 60.9 and 54.3% of cases, respectively. The false-negative result was 17.4% for ejection and 6.5% for the Ppeak/ESO m2 X index. Ejection and the Ppeak/ESV X m2 index were found to be highly informative. However in cases with a relatively preserved function of the left ventricle, it is necessary to take into account the magnitude of the Ppeak/ESV m2 X index which may attest to the pathological alterations in the myocardium in 62% of cases.

Adult↗
PubMed1984

[Effect of isosorbide dinitrate (isoket) on central hemodynamics and myocardial contraction in patients with ischemic heart disease].

The authors studied the effect of isoket on the central hemodynamics and myocardial contractility as well as on the conditions of myocardial functioning in 38 patients aged 28-53 years and suffering from coronary heart disease. The infusion of 2 mg of isoket at a rate of 400 micrograms/min was followed by a decrease in the arterial pressure with the maximum drop seen on the seventh minute (by 26% from the baseline value), a reduction in the end-diastolic pressure by 50%, and a lengthening of the preejection period without any significant changes in either the cardiac output or the total peripheral resistance. Taken as a whole these changes justify the conclusion that the influence of dinitrate isosorbite (isoket) on the central hemodynamics is largely due to its venodilating action leading to a reduction of the pre-load which in turn improves myocardial functioning.

Adult↗
PubMed1983

[Segmental contractility--criterion of the integral function of the left ventricle in patients with ischemic heart disease].

The expulsion fraction was examined with reference to qualitative and quantitative parameters of segment contractility of the left-ventricular wall in 68 coronary patients. Segment contractility of the left-ventricular wall can provide the basis for the interpretation of the left-ventricular integrative function in these patients. Its qualitative assessment can characterize the general condition of the myocardium, whereas its quantitative features may contribute to the elucidation of mechanisms involved in compensatory relationships between the damaged and intact myocardium of the left ventricle.

Adult↗
PubMed1980

[Nitroglycerin test in evaluating left ventricular contractile function in ischemic heart disease].

The nitroglycerin test was conducted in 21 patients with ischemic heart disease. The changes in the hemodynamic parameters of left-ventricular function, namely the end-diastolic pressure, the end-systolic and end-diastolic volumes, the ejection fraction, and the segmental contractility of the left-ventricular wall were studied. It was found that nitroglycerin discloses the zones of reparable asynergy and thus allows the area of true cicatricial changes of the myocardium to be clearly demarcated. All hemodynamic indices changed under the effect of nitroglycerin; the dynamics of the end-systolic volume and the ejection fraction made it possible to appraise the functional condition of the myocardium. The results obtained showed the importance of the nitroglycerin test in prognosing the results of myocardial revascularization and determining the volume of surgical intervention in aneurysms of the left ventricle.

Angina Pectoris↗
PubMed1980

[Interrelationship of cardiac output and myocardial contractility].

On examination of 56 persons, 4 were found to have no abnormalities of the cardiovascular system, in all of the others the diagnosis of ischemic heart disease was confirmed. The cardiac output was determined by means of a thermodiluter. The stroke work index, the total peripheral resistance, and the segmental contraction of the left-ventricular wall were calculated. Changes in the stroke volume in response to a stress test, left ventriculography, were studied. It was found that changes in the stroke volume do not correlate with the clinical and coronarographic manifestations of the disease and the condition of the contractility of segments of the left-ventricular wall in the absence of clinical symptoms of circulatory insufficiency. The trend of stroke volume changes recorded during the stress test showed a dependence on the volume and degree of left-ventricular asynergy. Changes in the stroke volume were determined by the initial value of the cardiac output. High sensitivity of the left-ventricular function curve in detecting dysfunction of the left ventricle as well stroke volume-total peripheral resistance feedback were revealed.

Cardiac Catheterization↗
PubMed1979

[Comparative evaluation of the myocardial contractile indices of the left ventricle in ischemic heart disease].

The indices of hemodynamics and myocardial contractility rate (end diastolic and end systolic volumes, ejection fraction, average rate of shortening of circumferential fibres, and average normalized rate of systolic ejection) were studied in 44 patients with ischemic heart disease to appraise the informative value of each parameter and reveal myocardial dysfunction. Calculations were done on an electronic computer system. The data obtained were compared with the findings in practically healthy persons. It was found that increase of the residual volume is the first sign of disturbed myocardial contractility and correlates well with the extent and volume of impaired contractility of the left ventricular segments. A decrease of the ejection fraction is noted only with an increase of the residual volume, the degree of the decrease correlating most closely with the degree of the decrease of the rate indices. The number and localization of the affected segments of the left ventricular wall have an effect on the contractile function of the myocardium.

Adult↗
PubMed1979

[So-called coronary angiographic paradoxes].

The results of examination of 25 patients (18 with ischemic heart disease and 7 with cardialgia of other etiology) are discussed. The arteriolo-capillary bed of the coronary arteries was studied by intraarterial injection of albumin aggregates labelled with radioactive isotopes. A correlation was revealed between the degree of microcirculatory disorders and the results of electrocardiography. With increase in the degree of microcirculatory disorders, cicatricial changes in the left ventricular myocardium were found more frequently and a history of myocardial infarction (in 11 persons) and the development of left ventricular aneurysm (in 2 patients) were noted. Certain indices of integral function (EF, VcF, MNSER) and regional contractility (% delta r, L) of the left ventricle were determined in 14 patients. Among these parameters characterizing left ventricular function (EF, VCF, MNSER, % delta r, L), VCF, MNSER, and % delta r, L are most sensitive. No correlation was revealed between the state of the myocardial microcirculation bed and EF, VCF, and MNSER, but a definite correlation was found between it and % delta r, L (in the form of regional hypo- and hyperkinesia and paradoxical pulsation). Normal coronary arteriograms do not exclude the presence of ischemic heart disease and other primary diseases of the myocardium. Patients of this category should be examined more scrupulously to detect disorders of blood supply to the myocardium and function of the left ventricle.

Coronary Angiography↗