PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 6774158

[Nitroglycerin test in evaluating left ventricular contractile function in ischemic heart disease].

I Kh Rabkin·V M Tkachenko·V M Abugov·G a Levina
View original source ↗Export metadata ↓

Abstract

The nitroglycerin test was conducted in 21 patients with ischemic heart disease. The changes in the hemodynamic parameters of left-ventricular function, namely the end-diastolic pressure, the end-systolic and end-diastolic volumes, the ejection fraction, and the segmental contractility of the left-ventricular wall were studied. It was found that nitroglycerin discloses the zones of reparable asynergy and thus allows the area of true cicatricial changes of the myocardium to be clearly demarcated. All hemodynamic indices changed under the effect of nitroglycerin; the dynamics of the end-systolic volume and the ejection fraction made it possible to appraise the functional condition of the myocardium. The results obtained showed the importance of the nitroglycerin test in prognosing the results of myocardial revascularization and determining the volume of surgical intervention in aneurysms of the left ventricle.

Explore related subjects

Angina PectorisCoronary AngiographyCoronary DiseaseElectrocardiographyHeart VentriclesHemodynamicsHumansMaleMyocardial ContractionNitroglycerinJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

I Kh Rabkin, V M Tkachenko, V M Abugov, G a Levina. 1980. [Nitroglycerin test in evaluating left ventricular contractile function in ischemic heart disease].. https://pubmed.ncbi.nlm.nih.gov/6774158/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

Effect of a hypoglycemic agent on ischemic preconditioning in patients with type 2 diabetes and stable angina pectoris.

OBJECTIVE: Ischemic preconditioning is an increased tolerance to myocardial ischemia during the second of two consecutive exercise tests. ATP-sensitive K(+) channel blockers, such as glinides and sulfonylurea drugs, can induce loss of ischemic preconditioning. This study aimed to investigate the effects of repaglinide, a hypoglycemic agent with an affinity for myocardial ATP-sensitive K (+)channels, on the results of consecutive exercise tests in patients with diabetes and multivessel coronary artery disease. METHODS: Forty-two patients with type 2 diabetes and chronic stable angina pectoris, and two-vessel or three-vessel disease participated in this study. The patients underwent two consecutive treadmill exercise tests (phase 1). On the day after these exercise tests, 2 mg of oral repaglinide was given to the patients. One week later, two exercise tests were repeated consecutively (phase 2). RESULTS: All patients achieved 1.0-mm ST-segment depression during the four exercise tests (T1, T2, T3, and T4). In phase 2, seven patients improved in time to onset of 1.0-mm ST-segment depression. The worsening of the time to onset of 1.0-mm ST-segment depression in phase 2 demonstrated ischemic preconditioning block in 83.3% of patients (P=0.0001). Even the postexercise electrocardiographic parameters (ST-segment depression morphology and magnitude and arrhythmias) were significantly different between the groups with and without pharmacologic ischemic preconditioning block (P=0.031). CONCLUSIONS: Repaglinide, an oral hypoglycemic agent with ATP-sensitive K(+) channel-blocker activity, eliminated the myocardial ischemic preconditioning in patients with coronary disease and diabetes.

Angina Pectoris↗