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Biomedical subjects

V Menon

Publications and source records attributed to V Menon.

At least 109 records · Page 6Linked to original sources
PubMed1989

Antinuclear antibodies and anticytoplasmic antibodies in bronchial asthma.

The presence of antinuclear antibodies and anticytoplasmic antibodies was evaluated in the sera of 50 patients with bronchial asthma and 35 matched control subjects with miscellaneous medical diseases with the use of an indirect immunofluorescent assay with HEp-2 cells as substrate. The results were compared to age, sex, atopic status, dose, and duration of the antiasthmatic medication, immunotherapy, severity of the disease, and presence or absence of myalgia. The patients had mild to moderate asthma. The incidence of fluorescent anticytoplasmic antibodies (FACA) in the sera of patients with asthma was statistically significant (p = 0.02) in comparison to FACA in the sera of the control subjects. The combined incidence of fluorescent antinuclear antibodies (FANA) and FACA was found to be significantly higher among atopic subjects with asthma (p = 0.03) and the subjects with asthma and with myalgia (p less than 0.05). The 20% incidence of FACA in this group of subjects with asthma was significantly greater (p less than 0.0001) than the reported 2.7% incidence of FACA in a group of patients with various rheumatologic diseases. Variables, such as dose and duration of antiasthma medications and immunotherapy did not appear to influence the presence of FANA and FACA in their sera. The significance of positive FANA and FACA in this group of subjects with asthma is not known and needs to be evaluated by long-term studies.

Antibodies↗
PubMed1988

Assessment of response to oral metaproterenol sulfate by forced oscillation in young children.

The dose response characteristics and side effects of three doses of oral metaproterenol sulfate (MS) (0.4, 0.6, and 0.8 mg/kg) were compared with a placebo in ten asthmatic children (3 to 6 years). The bronchodilator efficacy was objectively assessed by evaluating the decrease in mean total respiratory resistance (MTRR) using Oscillaire. The mean percentage changes from baseline in MTRR showed that MS in all three doses was more effective than placebo. Lack of objective demonstration of bronchodilator efficacy, concern for possible side effects and uncertainty of the precise dosage for adequate bronchodilation are some of the factors that account for the lack of specific dosage recommendations for bronchodilators such as oral metaproterenol sulfate in children under 6 years of age. Until recently, it was not possible to objectively measure the response to bronchodilators in children below 6 years of age because of their inability to reliably perform forced expiratory maneuvers required for spirometry and their unwillingness to have airway resistance (or conductance) measurements by body plethysmography. Direct measurements of airflow resistance have been made in children with a pneumotachograph at the mouth and a balloon in the esophagus to record transpleural pressure changes; however, these techniques are invasive and require sedation. Total respiratory resistance and reactance of the respiratory system, as measured by forced oscillation technique, are pulmonary function tests that can be performed in young children who are unable to cooperate with conventional spirometric maneuvers.

Administration, Oral↗
PubMed1987

Amoebic peritonitis in pregnancy in the United Kingdom.

We describe a woman who developed hepatic amoebic abscesses during pregnancy, and subsequently amoebic peritonitis. We believe this to be the first such recorded case in the United Kingdom, and unusual in that the patient had never been abroad.

Adult↗
PubMed1987

Saccadic eye velocity in concomitant divergent squint.

Study was conducted on 10 normal subjects, 20 cases of unilateral divergent squint and 20 cases of alternating divergent squint. In unilateral divergent squint cases lateral rectus of nondominant eye showed overactivity on fixation with dominant eye. In the alternating divergent squint cases which had onset of squint at or after the age of 2 years showed increased saccadic velocity of medial rectus of non-dominant eye on fixation with dominant eye. Working hypothese have been suggested to explain these phenomena.

Eye Movements↗
PubMed1987

Nerve fibre bundle defects and their perimetric correlation.

The importance of red-free fundus examination in revealing functional loss of the retinal nerve fibre layer is highlighted in some optic nerve diseases as corroborated by a good correlation observed between NFBDs and visual field defects. Red-free fundus examination could predict the site of a visual field defects, thus enabling the perimetrist to concentrate on that area and to detect field defects which were missed in a previous field examination. In cases of optic atrophy, the extent of nerve fibre layer loss correlated better with the functional loss in terms of visual acuity rather than the pallor of the disc, which was quite often misleading as an indicator of functional damage of the optic nerve. The technique of red-free fundus photography employed was fairly inexpensive and simple.

Fundus Oculi↗
PubMed1986

Anterior segment ischemia following extraocular muscle surgery.

An experimental study was conducted on rhesus monkeys using the technique of anterior segment fluorescein angiography to determine the changes that occur in the iris circulation following surgery on extraocular recti muscles in various combinations and to investigate the safe time limit to perform further surgery on the remaining recti muscles. Based on the results, the probable blood supply to the iris and its clinical significance is discussed. It is concluded that the often quoted clinical safe period of 6 weeks is not enough from the angiographic point of view, as the iris circulation is not fully normalized by that time.

Animals↗
PubMed1984

Pulsatile administration of GnRH for the treatment of hypogonadotrophic hypogonadism.

Fourteen patients, aged 22-35 years, complaining of infertility and failing to ovulate on clomiphene, were treated with GnRH administered in pulses at 90 min intervals. Four patients received a total of eight courses of GnRH given subcutaneously and 13 were given a total of 20 months of treatment with GnRH given intravenously. Serum concentrations of immunoreactive GnRH were measured in six patients before administration of the drug and at regular intervals for 60 min after subcutaneous and intravenous injections of 5, 10 and 20 micrograms GnRH. Maximum concentrations of GnRH were reached by 5-10 min after subcutaneous injections and within 2 min after intravenous injections. The peak concentrations were 3.6-6.3 times and the sums of increments were 2.0-3.9 times greater following intravenous injections than after subcutaneous injections. Subcutaneous treatments extended for 15-29 days with doses of 5-20 micrograms per pulse. Only one patient ovulated as judged by the luteal phase progesterone and ultrasonic scanning of the follicle. Intravenous treatments were from 12-22 days with doses of 10 micrograms per pulse and 16 treatments out of 20 were ovulatory with four pregnancies. HCG (5000 i.u.) was given when ultrasonic scanning indicated adequate follicular growth, but in eight of the cycles, including three of the pregnancies, the follicle had ruptured before HCG was given. Pulsatile administration of GnRH proved to be an effective treatment for infertility in hypogonadotrophic hypogonadism. Possible reasons for the better results by intravenous rather than subcutaneous injections are discussed.

Adult↗
PubMed1984

Review of 59 patients with hypergonadotrophic amenorrhoea.

Fifty-nine patients presented with elevated concentrations of gonadotrophins and secondary amenorrhoea before the age of 35 years. Fifty-three underwent laparoscopic examination and primordial follicles were observed in 16. Two others had follicles as they later became pregnant and a third showed biochemical evidence of spontaneous ovulation. There were streak ovaries in 12, two with follicles and three others with chromosomal abnormalities, two being 47XXX and one XO/XX. Two other patients had only one ovary each but no follicles. Chromosomal abnormalities were detected in two further patients one being XO/XX and the other a recombinant. Six patients became pregnant, two of them twice, resulting in four term deliveries and four spontaneous abortions. Three other patients showed biochemical evidence of ovulation; one spontaneously, one after oestrogen therapy and the third after treatment with gonadotrophin releasing hormone analogue.

Adolescent↗