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V N Kuz'menko

Publications and source records attributed to V N Kuz'menko.

6 recordsLinked to original sources
PubMedDate not supplied

[The mechanisms of the decrease in prostatic mass in rats during the administration of estrogenic preparations into the cerebrospinal fluid].

Experiments on albino male rats have shown that the endoliquor administration of estrogens at low doses results in the inhibition of proliferative processes in the prostatic tissues comparable with that observed at the administration of doses two orders larger, and at the subcutaneous administration. A study of the possible mechanism of the observed phenomenon has shown that this effect is associated with the fact that in such a way of estrogen administration conditions are created for deeper inhibition of the production of gonadotropins by the adenohypophysis, and as a result of it a decrease in the androgen level is observed leading to the inhibition of proliferative processes in the prostatic tissues.

Animals↗
PubMedDate not supplied

[Effect of central and peripheral estrogen administration on the indices of immune homeostasis].

The effect of high (50 micrograms) and low (2.5 micrograms) doses of diethylstilbestrol propionate (DES) oil solution injected into the CSF and intramuscularly was studied on non-inbred albino male rats. The drug was administered four times with 5 to 6 days' intervals. At the 4th day after the last DES injection the animals were immunized with the sheep red blood cells. The animals under study were killed and the state of their genital organs (testicles and prostatas) was examined. Immunity was evaluated according to the blast-transformation response of the peripheral blood lymphocytes, stimulated by phyto-hemagglutinin and Con A in accordance with the nucleus-containing splenocyte (NCS) and the antibody-forming cell (AFC) number, as well as by the rosette-forming cell (RFC) per cent content in the spleen. It was found that high and low DES doses exert a pronounced effect on the genital organs of the animals. Large doses of the drug affect the immune homeostasis by decreasing blast-transforming lymphocyte ability and NSC number simultaneously with a sharp AFC number and RFC per cent rising. Low DES doses did not influence the immunity indices.

Animals↗
PubMedDate not supplied

[Comparative study of the effectiveness of various doses of estrogens after their "central" and "peripheral" administration].

Experiments on male rats were made to study the effects of synestrol and diethylstilbestrol on the sexual organs. The drugs were administered subcutaneously and into the CSF. Diethylstilbestrol propionate produced the most potent inhibitory action on proliferative processes in the prostate. This inhibition was found to be the most demonstrable when the drug was administered into the CSF. During endo-CSF administration the dose of the hormone could be considerably decreased, with the inhibitory action on the target organs being unchanged and side effects on the animal body being minimal.

Animals↗