[The mechanisms of the decrease in prostatic mass in rats during the administration of estrogenic preparations into the cerebrospinal fluid].

Iu N Bordiushkov; V N Kuz'menko; L D Kirsanova

PubMed · 2109865

[The mechanisms of the decrease in prostatic mass in rats during the administration of estrogenic preparations into the cerebrospinal fluid].

Iu N Bordiushkov·V N Kuz'menko·L D Kirsanova

Abstract

Experiments on albino male rats have shown that the endoliquor administration of estrogens at low doses results in the inhibition of proliferative processes in the prostatic tissues comparable with that observed at the administration of doses two orders larger, and at the subcutaneous administration. A study of the possible mechanism of the observed phenomenon has shown that this effect is associated with the fact that in such a way of estrogen administration conditions are created for deeper inhibition of the production of gonadotropins by the adenohypophysis, and as a result of it a decrease in the androgen level is observed leading to the inhibition of proliferative processes in the prostatic tissues.

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Animals Cerebrospinal Fluid Depression, Chemical Dienestrol Diethylstilbestrol Dose-Response Relationship, Drug Follicle Stimulating Hormone Injections Luteinizing Hormone Male Organ Size Phenols Prostate Rats Testis Testosterone Comparative Study English Abstract Journal Article

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Iu N Bordiushkov, V N Kuz'menko, L D Kirsanova. [The mechanisms of the decrease in prostatic mass in rats during the administration of estrogenic preparations into the cerebrospinal fluid].. https://pubmed.ncbi.nlm.nih.gov/2109865/

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