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V Nagy

Publications and source records attributed to V Nagy.

46 records · Page 3Linked to original sources
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[Serum and secretory immunoglobulins in immature infants].

The authors determined the serum and salivary concentration of albumin and immunoglobulins G, A and M in 16 dysmature and 16 healthy infants, born at term, mean age 4.8 +/- 1.8 and 4.7 +/- 1.4 respectively. The ratio of the amounts of salivary immunoglobulins transmitted from the blood to those secreted locally, applying the formula of Deuschl and Johansson, completed by the authors. The mean albumin, IgA and IgG levels were lower in the dysmature infants probably due to immaturity of the elements that synthesize these proteins, i.e. accelerate protein metabolism. Marked differences were observed in serum IgM between the two lots. In the saliva of immature infants albumin concentrations were very high probably due to the permeability of the physiologic barriers higher in these children due to insufficient biological maturity of the tissues. IgG concentration in the saliva showed no marked differences between the two groups, but the fraction filtered from the blood was greater in the immature infants, likewise attributed to massive transudation. More than 99% of immunoglobulin A in the saliva is of local origin and shows no considerable difference between the two groups.

Humans↗
PubMedDate not supplied

Serum and salivary proteins in dysmature infants.

Concentrations of immunoglobulins and other plasma proteins were determined by radial immunodiffusion in the blood sera and saliva of 16 dysmature (small-for-dates) and of 16 eutrophic healthy infants with an average age of 4.8 and 4.7 months, respectively. The local synthesis of salivary proteins was calculated with a formula used by Deuschl and Johansson for the estimation of local synthesis of bronchial immunoglobulins. The formula was completed by a correction factor established by the authors, based on their previous investigations. Dysmature children had a significantly lower serum IgG, IgA, albumin, transferrin, coeruloplasmin and beta-lipoprotein level. In the dysmature infants the salivary albumin and alpha 1-acid glycoprotein concentration was higher than in the normal controls. A local synthesis of IgA, IgG, transferrin, alpha 1-acid glycoprotein, alpha 1-antitrypsin and haptoglobin was observed in both groups, but the production of these proteins was slightly diminished, while their transudation was more important in the dysmature subjects. The lower level of serum proteins, as well as the lower local synthesis in the salivary glands may be due to the immaturity of the tissues that produce these proteins. The increase of the protein transudation is attributed to a rise of the tissue permeability in the dysmature children which is a late consequence of intrauterine malnutrition.

Blood Proteins↗
PubMedDate not supplied

Glomerular prostanoid production is modified by plasma samples of hypertensive and diabetic patients.

The autocrin-paracrin prostanoid system plays a major role in the enhancement or inhibition of renal tissue damage. Our hypothesis was that there might be circulating factors in the plasma with a capability to modify renal (glomerular) prostanoid synthesis. We measured the synthesis of prostacyclin 1-2 (PGI2) and thromboxan A-2 (TxA2) of isolated glomeruli, incubated in plasma samples obtained from hypertensive and diabetic (NIDDM) patients. It was found that these plasma samples decreased the renal PGI2/TxA2 ratio, mostly by decreasing glomerular PGI2 synthesis and, to a lesser extent, increasing the synthesis of TxA2. Our results demonstrate that circulating factors in hypertension and diabetes might play a role in renal damage seen in these conditions.

Adult↗