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Biomedical subjects

V S Eremeev

Publications and source records attributed to V S Eremeev.

At least 19 recordsLinked to original sources
PubMed2000

[Local cerebral blood flow, cortical impedance, cerebral intravascular kinin production during forebrain ischemia and reperfusion in rats].

In the rat model of forebrain ischemia with subsequent reperfusion, an obvious formation of intravascular kinin (IVKF) occurred. The IVKF preceded and coincided in time with the maximum hyperemia and a vasogenic oedema. Local cerebral blood flow (LCBF) increased up to about 187%, at that. In three groups of experimental rats, a correlation was revealed among the ischemia obviousness, IVKF, and development of the brain oedema.

Animals↗
PubMed1999

[Arterial mechanoreceptor reflex as a factor for execution of hypertensive responses to disturbing effects].

It has been shown in experiments on conscious cats and rats that arterial mechanoreceptor reflex is inhibited during averse emotional influence, and the changed reflex is a cause of elevation in arterial pressure. In one's turn the hypertension contributes to entry of blood plasma norepinephrine into brain and in this way increases the arterial baroreceptor reflex after the emotional influence is stopped. The augmentation of baroreflex promotes restoration of homeostasis after cessation of the stress situation.

Animals↗
PubMed1996

[The mechanisms regulating the value of the arterial pressure in alert rats].

N-g-nitro-L-arginine increased the mean arterial pressure in intact alert rats against the background of phenoxybenzamine and captopryl, as well as benzohexonium. The findings suggest that systems of short-term blood-pressure control are limited by the sympatho-adrenal vasopressin and renin-angiotensin systems.

Adrenal Glands↗
PubMed1996

[The possible mechanism of the noradrenaline enhancement of the arterial baroreceptor reflex].

In anaesthetized cats intravenous infusion of norepinephrine induced the increase in arterial pressure and suppression of renal nerve electrical activity. The latter followed the infusion was stopped and arterial pressure returned toward control. The baroreflex suppression of sympathetic activity associated with norepinephrine increased in the case of preliminary mechanical damage to blood-brain barrier. Duration and intensity of the sympathetic activity suppression following norepinephrine infusion depended on the magnitude of hypertensive reaction and the rate of elevating in arterial pressure under the action of norepinephrine. Norepinephrine at the similar concentrations did not depress sympathetic activity if the arterial pressure was stabilized on the resting level. These data support the supposition that the elevation of arterial pressure due to norepinephrine infusion increases the ability of catecholamine to enter brain and in this way activates the central limb of arterial baroreceptor reflex.

Adrenergic alpha-Agonists↗
PubMed1994

[The variability of the arterial pressure in waking normotensive rats].

Specifics of arterial pressure, interrelationships among the arterial pressure, heart rate and baroreceptor reflex, were studied in alert normotensive rats. Absence of any correlation between the middle level of arterial pressure and the latter's variability, was shown. No connections among the above parameters were found either.

Animals↗
PubMed1993

[The role of the endothelium-derived relaxing factor in regulating the distensibility of the vessels of the arterial bed].

The inhibiting agent N-nitro-L-arginine was shown to constrict the hindlimb arterial vessels and to decrease their distensibility in the cats with the synthesis of the endothelial relaxing factor. Acetylcholine exerted an opposite effect. The EDRF system seems to have a tonic activity whereas some unrelated factors are involved in the acetylcholine effect.

Acetylcholine↗
PubMed1991

[An analysis of the mechanisms enhancing arterial baroreceptor reflexes during noradrenaline infusion].

In cats-recipients with cut vagosympathetic trunks and hemodynamically isolated carotid sinuses, the latters were perfused with the blood from a cat donor. Noradrenaline infusion did not change the electrical activity of the renal nerve and induced an inhibition of the activity in high perfusion pressure. Noradrenaline seems to induce a short-term enhancement of arterial baroreflexes and to potentiate the effect on the central link of the reflex arch.

Animals↗
PubMed1990

[The participation of arterial baroreceptor reflexes in the prolonged inhibition of the electrical activity of the sympathetic nerves].

In immobilised male cats, arterial and venous pressure, heart rate and electrical activity of the renal nerve were recorded during i.v. infusion of noradrenaline at a constant initial level of arterial and venous pressure. The electrical activity of the renal nerve was inhibited and the heart rate decelerated, the obviousness of these effects increasing with acceleration of the infusion rate. The bradycardia was transient in anesthesia. The section of both vago-sympathetic trunks prevented the bradycardia and weakened the inhibition of the renal nerve activity. Additional denervation of both carotid sinuses eliminated the inhibiting effect of noradrenaline. Possible mechanisms of the noradrenaline effects are discussed.

Afferent Pathways↗
PubMed1988

[Analysis of compensatory mechanisms of arterial hypertension in norepinephrine infusion].

The NA infusion induced a raise in the AP, inhibition of sympathetic vasomotor activity and a drop in the heart rate in alert male cats. The hypertensive effect of the NA was weakening during first 90 min of the infusion, a complete inhibition of sympathetic activity persisted during the whole period of infusion as well as a decrease in the heart rate, in anesthetized cats. After deafferentation, the markedness of the arterial hypertension weakening decreased and the effect of the infusion on sympathetic activity and heart rate was abolished. Administration of pentamine during the infusion did not affect the AP in anesthetized cats, increased it in alert animals and decreased the AP in deafferented cats. The organism seems to have no humoral mechanisms of compensation of arterial hypertension induced with the 3-hr infusion of noradrenaline.

Animals↗
PubMed1987

[Increased arterial pressure in negative emotions as one of the functions of the baroreceptor reflex].

An experimental study in conscious rats with intact and denervated sinoaortic baroreceptor zones has been concerned with arterial BP changes in response to negative and positive emotions. Negative emotions are shown to suppress both the cardiochronotropic and the vasomotor components of the baroreceptor reflex. The role of the baroreceptor reflex in the provision of BP changes in response to negative and positive emotions is discussed.

Animals↗
PubMed1986

[Role of afferentation from mechanoreceptors of the aortic arch and carotid sinuses in the long-term control of sympathetic tone].

In anesthetized cats, the enhancement of sympathetic activity and increase of the blood pressure in exclusion of afferents (section of vagosympathetic trunks and clamping of common carotid arteries) as well as the disappearance of the activity in enhanced afferentation, were shown to be transient and to disappear within a few minutes-scores of minutes in spite of the going on deafferentation or enhancement of afferentation. The afferent influences from the arterial baroreceptors seem to have no major significance for the long-term control of sympathetic tone.

Animals↗