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Biomedical subjects

V V Dongre

Publications and source records attributed to V V Dongre.

7 recordsLinked to original sources
PubMed1976

A study of mono-neuritic lesions in a leprosy clinic.

An analysis of 11,581 leprosy patients registered at the Acworth Leprosy Hospital clinic showed that 494 cases (4.3%) had primary polyneuritic leprosy and 143 (1.2%) localised cutaneous anaesthetic lesions (or non-visible anaesthetic lesions), accounting for 5.5% who had no evidence of obvious skin lesions.

Adult↗
PubMed1976

Clinical trial with clofazimine in leprosy.

This paper summarises our clinical experience with clofazimine in the treatment of 25 cases of reactive states of lepromatous and borderline leprosy and 7 lepromatous patients not responding to dapsone. Corticosteroids, which had to be given for the control of reactions, could be withdrawn and daspone therapy reintroduced during the period of administration of clofazimine. A schedule for the management of moderately severe reactions is recommended. The results of clofazimine treatment were also equally impressive in the group of patients, possibly harbouring dapsone resistant bacilli (in view of their lack of improvement in spite of administration of dapsone under controlled conditions). Clinical regression was associated with a fall in the mean levels of morphological index from 6.8 to 0.5. The need to realise the real indications of this highly useful drug in the treatment of leprosy is stressed.

Adolescent↗
PubMedDate not supplied

Pattern of drug compliance in leprosy patients attending urban centres--a longitudinal study.

The pattern of drug compliance in 485 leprosy patients attending urban leprosy centres in Bombay was studied for 2 years. The study subjects included 113 patients with paucibacillary leprosy under dapsone monotherapy, 241 patients with paucibacillary leprosy under multidrug therapy and 131 patients with multibacillary leprosy under multidrug therapy. Their urine samples had been checked at least 6 times during the 2 years by DDS tile test at the time of their clinic attendance. The urine test results were not disclosed to the patients, but patients showing negative results were counselled about the need for regular drug intake. 35% of the patients were "Regular through out", 13% were "Irregular through out" and the other 52% who "Tended to be irregular" in their drug intake became "Regular" after counselling. Regularity in drug compliance was better in patients on multidrug therapy than in those on monotherapy. It is suggested that periodic testing of urine for checking for regularity of drug intake and subsequent counselling of patients should be made a routine practice to maintain drug compliance at a high level.

Dapsone↗
PubMedDate not supplied

Prevalence of leprosy in slums in Bombay including a leprosy colony.

Transmission of leprosy which is related directly to the total quantum of infection in the community as a whole is decided by the existence of patients suffering from progressive and infectious forms of leprosy and their movement from place to place. This information is of great importance in cities like Bombay to identify the priority areas as targets towards which control efforts should be directed. In this presentation an attempt has been made to compare the leprosy survey figures from three different situations in the city. Selection is arbitrary, not made on statistical basis. The data of particular importance is from a leprosy colony located in North Bombay representing a hyperendemic situation and a normal slum adjacent to this colony, movement of population between these two colonies being free. Age specific prevalence rates of leprosy after examining more than 80% of population from these colonies are compared with data derived from normal slums situated elsewhere in the city. The figures reveal varying prevalence rates marked by an increasing trend in the prevalence figures, leprosy colony representing the largest pool of infection. These figures indicate that wider statistically planned investigations on similar lines in urban areas may provide epidemiological data useful for planning control measures on a more rational basis.

Adolescent↗
PubMedDate not supplied

Leprosy detection through non-survey techniques.

Most practical and cheap techniques other than mass surveys to detect leprosy in urban slums are still not known. The population inhabiting a large somewhat isolated slum in North Bombay was exposed to intensive health education programmes over a period of two years. Leprosy cases reporting as a result of these measures as well as those detected by trained workers casually or through contact examination were registered at two weekly clinics conducted within the slum. A total of 184 patients out of whom 27 were smear +ve, were identifiable by these means. The population of the slum was found to be 18228. Total prevalence rate of leprosy after examining 14723 subjects in the colony was revealed to be 24 per 1000 (smear +ve cases: 2.2. per 1000) out of which a prevalence of 12.4 per 1000 (smear +ve cases: 1.8 per 1000) had actually come to our knowledge even before instituting mass surveys. The results of this study indicate that in comparable urban situation it should be possible to identify 54% of total leprosy cases by techniques other than surveys. More significantly a striking feature of this study is that 82% of cases of true public health significance namely smear +ve patients could be unearthed by these means.

Health Education↗