Biomedical subjects
Publications and source records attributed to V V Eliseev.
Uridine and uridine-5'-monophosphate prevent myocardial stunning during postischemic reperfusion of isolated rat heart. Uridine-5'-diphosphate does not prevent postischemic myocardial dysfunction, while uridine-5'-triphosphate aggravates it.
The rat hearts were subjected to 60-min ischemia by left coronary artery ligation followed by 60-min reperfusion, involving intravenous adenosine inosine or guanosine given in a dose of 1 mg/kg.min-1 in the first 30 minutes of reperfusion. Ischemia and subsequent reperfusion caused a progressive decrease in cardiac output and coronary blood flow. Adenosine was found to enhance coronary blood flow and increase cardiac and stroke outputs. Inosine produced nearly the same, but less pronounced effect. Guanosine increased cardiac output without changing coronary blood flow.
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The authors studied prophylactic action of adenosine analogs during ischemic liver damage. Hepatoprotective action of adenosine analogs was established.
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The influence of adenosine on hemodynamic changes induced by electrostimulation of reflexogenic zone of aorta was studied in this article. It was shown that 3-hour electrostimulation increased the total peripheral resistance and decreased cardiac output and aortic pressure. Intravenous infusion of adenosine during electrostimulation led to the normalization of main indices of hemodynamics.
Adenosine, administered intravenously (0.25 mg/kg-1/min-1) to rabbits with experimental myocardial infarction, produced a drop in arterial pressure and total peripheral resistance, normalized stroke volume, increased ATP content at the margin of the infarcted area, and reduced LDG activity and increased SDG activity in the ischemized region.
In rabbit experiments, adenosine was studied for its effects on the sizes of myocardial infarction and "no reflow" zones after coronary artery occlusion and reperfusion. Intravenous administration of adenosine resulted in a steady drop in blood pressure, decrease in heart rate and increase in the extent of infarction and "no reflow" zone.
In anesthetized rats a 30-min intravenous infusion of adenosine (2.5 mg/kg/min) performed after the coronary artery ligation significantly decreased the incidence and severity of early ischemic arrhythmias. After the infusion of adenosine, there was an increase in cGMP level in the left ventricular myocardium, cAMP content remained unchanged.
In anesthetized cats, i.v. administration of adenosine reduced the mean systemic blood pressure and systemic vascular resistance while increasing the cardiac output and coronary blood flow.
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In anesthetized rats, i.v. administration of adenosine (2.5 mg/kg/min) for 30 min caused reduction of mean systemic blood pressure. A significant decrease of blood flow was found in mesentery microvessels as well as dilation of arterioles and venules.
The chronotropic and inotropic effects of guanosine-5'-monophosphate (5'-GMP) and inosine were investigated in isolated frog hearts. 5'-GMP induced biphasic chronotropic and inotropic responses: positive those were inhibited with propranolol, the negative inotropic response could not be inhibited with atropine. Inosine was able to enhance the positive inotropic response to 5'-GMP.
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The possibility of employing collalysin used in clinical practice for histochemical studies was explored. Collalysin which is a highly purified bacterial collagenase has a marked collagenolytic effect and, unlike commercial collagenases, exerts no nonspecific effect on collagen fibers.
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