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Biomedical subjects

V V Eliseev

Publications and source records attributed to V V Eliseev.

At least 37 records · Page 2Linked to original sources
PubMed1980

[Mammary gland tumor induction in rats by N-nitroso-N-methylurea and N-methyl-N1-nitro-N-nitrosoguanidine].

Cancer of the mammary gland was induced in female non-inbred rats under the local effect of N-nitroso-N-methylurea (NMU) and N-methyl-N-nitro-N-nitrosoguanidine (MNNG). During 10 weeks 2.5 mg of the substance in 0.2 ml of saline was injected in the region of the third mammary gland once a week. Under NMU exposure a primary tumor arose 3 months following the initiation of the experiment, the average latent period being 5.8 months, the incidence rate--76.7%. All tumors of this series were adenocarcinomas, in 5 cases there were noted sites of fibroadenomatosis with malignification along the tumor node margins. MNNG produced a primary tumor at the 7th month of the experiment, an average latent period--8.3 months, the incidence rate--56.7%. Tumors were mostly adenocarcinomas.

Animals↗
PubMed1980

[Histochemical and ultrastructural characteristics of sarcomas induced by plastic strips].

During histochemical studies of sarcomas, induced in rats by skin implants of ethacryl plastic, fuchsinophil and argyrophil fibres were found as well as the deposits of chondroitin-4-and chondroitin-6-sulfate in the intercellular space of tumors. Electron microscopy enabled determination of collagen fibrilles and collagen fibre bundles even in low-differentiated neoplasms. Based on the histochemical and ultrastructural features in all these disc-induced tumors are referred to as fibrosarcomas.

Acrylic Resins↗
PubMed1979

[Changes in the urinary bladders of rats during experimental carcinogenesis].

Rats receiving with drinking water a 0.4% solution of a-butyl-N-butanol-nitrosamine developed by 4 months transitional cell papillomas and by 10 months transitional cell carcinomas in their urinary bladders. Histochemical examinations of the transitional epithelium in the course of malignization revealed a gradual decrease in the activity of nonspecific alkaline phosphatase and increased activity of monoaminoxidase and beta-glucuronidase. A significantly increased activity of nonspecific acid phosphatase was observed in areas of squamous cell metaplasia.

Alkaline Phosphatase↗
PubMed1978

[Effect of DL-tryptophan on blastomogenesis induced by acrylic plastic].

Plastic plates implanted subcutaneously to rats induced sarcoma in 11 of 27 animals (40.7%) which survived up to the time of the first tumour appearance (12.3 months). No tumours were revealed at the sites of the plastic powder implantation. Following long-term administration of DL-tryptophan tumours developed around the plates in 6 to 19 rats (31.5%) in 13.8 months, and around the powder in 2 of 5 rats which survived for 18.7 months. Some animals of this group displayed preneoplastic changes around the powder clumps.

Acrylates↗
PubMed1977

[Morphology and morphogenesis of cancer of the gallbladder and extrahepatic biliary ducts].

The article presents a survey of the problems of pathological anatomy, morpho- and histogenesis of cancer of the gallbladder and extrahepatic biliary ducts. Data on the role of inflammatory epithelial hyperplasias, adenomatous polyps in the subsequent malignancy of the biliary tract mucosa are presented. Problems of squamous-cell carcinoma of this localization are discussed. Results of experimental studies of tumours of the biliary ducts are presented.

Adenocarcinoma↗
PubMedDate not supplied

[The role of the muscarinic, adenosine and adrenoreceptors of the heart in the development of postischemic reperfusion ventricular fibrillation].

The authors studied the effect of m-cholino-, adreno-, and purinotropic agents on the development of postischemic reperfusion fibrillation of isolated rat hearts. Pilocarpine, norepinephrine, phenylephrine, and adenosine caused a proarrhythmogenic effect. Atropine, trimedoxim, prazosin, and chloroquine made fibrillation less expressed. A direct correlation was found between the arrhythmogenic effect of reperfusion and the size of the no-reflow zone, with the use of the drugs too. It is concluded that the phospholipid mechanism contributes to realization of the arrhythmogenic effect of reperfusion and vascular disorders, leading to the occurrence of the no-reflow phenomenon.

Adrenergic Agonists↗
PubMedDate not supplied

[Action of regulators of peripheral cholinergic processes on development of early arrhythmia in myocardial ischemic rats].

Occlusion of the left coronary artery in rats provoked ventricular tachycardia (VT) and ventricular fibrillation (VF) within the first 30 min of ischemia leading to death in 20% animals. Methacin (i.v., 100 micrograms/kg) significantly prolonged VT and VF without effects on the survival. Acetylcholine (i.v., 10 micrograms/kg/min) had no influence on VT frequency and severity but prevented VF. Rats from this group survived. The same effect was observed for neostigmine (i.v., 25 micrograms/kg). Nicotine (i.v., 2.5 micrograms/kg/min) prolonged VT episode duration but did not change frequency and severity of VF and survival. Ganglioblockers hexametony and azametony (i.v., both in a dose 500 micrograms/kg) significantly attenuated VT, prevented VF and death of the animals. Thus, cholinotropic drugs may have both antiarrhythmic and proarrhythmogenic effects in early arrhythmias induced by ischemia.

Acetylcholine↗
PubMedDate not supplied

[The effect of uridine and uridine nucleotides on isolated rat heart performance in regional myocardial ischemia].

We studied the effects of uridine, uridine-5'-monophosphate (UMP), uridine-5'-diphosphate (UDP) and uridine-5'-triphosphate on contractility, coronary flow and heart rate in isolated perfused rat hearts under 60-minute regional ischemia of the left ventricle. All the compounds (50 mumol/l) induced a positive inotropic effect but had no effect on the heart rate. Uridine and UMP prevented the development of the contracture. UDP and especially UTP increased coronary flow. Probably, a protective effect of uridine and UMP is due to activation of myocardial glycogen synthesis while favourable effects of UDP and UTP on contractility and coronary flow are explained by their influence on P2U-receptors of cardiomyocytes. In addition, coronary dilatation induced by UDP and UTP promoted the reduction of the damaged zone.

Animals↗
PubMedDate not supplied

[Effect of essential phospholipids on intensity of lipid peroxidation in the myocardium in experimental post-hypoxic reoxygenation].

Correction of the lipid peroxidation rate using essential phospholipids was studied. The phospholipids were used in protection of heart tissue in experimental posthypoxic reoxygenation. Administration of essential phospholipids into the rats during myocardium reoxygenation led to an increase in activity of superoxide dismutase. The drugs containing essential phospholipids may be used in clinical practice for treatment of the impairments when elevated lipid peroxidation occurred.

Animals↗
PubMedDate not supplied

[Mathematical modeling of movement of cilia in olfactory cells].

A mathematical model of the movement of olfactory cilia in different conditions was constructed. The realization of the model includes the development of a mechanical mathematical rheological model of the behavior of a continuous deformable medium, the development of the method of solution adapted to this problem, and obtaining a numerical solution, which takes into account different starting data. The mathematical modeling of the dynamic behavior of a deformable medium was performed using a system of equations for the dynamics of the deformable medium and the solution of the corresponding nonstationary system of equations in partial derivatives.

Cell Movement↗
PubMedDate not supplied

[The effect of guanosyl-5'-monophosphate on metabolic processes in rats with experimental myocarditis].

Ten days course of 5'-GMP intramuscular administration at a dose of 25 mg/kg into rats with adrenaline-produced myocarditis led to normalization of NAD content in myocardial tissue which contributed to restoration of NAD-dependent isocitrate dehydrogenase activity. During the 5'-GMP administration content of ATP and creatine phosphate was kept at the same low level as compared with controls, while restoration of glycogen content was retarded in the heart muscle. Activity of lactate dehydrogenase and lactic acid content were not altered. The decrease in content of pyruvic acid detected in response to 5'-GMP administration may occur due to elevated decarboxylation of pyruvate as a result of NAD content increase in heart muscle.

Animals↗