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V V Ivashchenko

Publications and source records attributed to V V Ivashchenko.

66 records · Page 4Linked to original sources
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[Effects of sodium hypochlorite on the course of recovery of structural elements and functions of the kidneys in postischemic period].

Kidney morphological structure, function and enzymuria were studied in experiment on 22 non-inbred rats of 200-280 g body weight with 90 min kidney ligature ischemia on day 3 and 7. In experimental group (11 rats) 1 ml 0.06% solution of sodium hypochlorite (SH) was injected intraperitoneally daily after kidney ischemic damage. 11 rats of the control group received 1 ml 0.89% SH solution in daily intraperitoneal injections. Morphological changes in renal structure, functional capacity of the kidneys, enzymuria on experimental day 3 and 7 were studied. It was revealed that SH injected in acute ischemic phase aggravated kidney cell damage. However, SH induced kidney reparative reaction on day 3. In the control group this reaction was registered only on day 7. It is suggested that SH may be an effective prophylactic modality against ischemic renal damage.

Animals↗
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[Increase in structural-functional tolerance of kidney to ischemia upon parenteral administration of sodium hypochlorite in the pre-ischemic period].

The opportunity of raising kidney structural and functional tolerance to ischemia with parenteral injections of 0.06% solution of sodium hypochlorite for 4 days in preischemia period was studied in experiment on 22 non-inbred rats of 200-280 g body weight. 90 minute ischemia was created by ligating the left and right kidney arteries, veins, ureters. Morphological and functional kidney data, enzymuria activity of nephron epithelium cells were registered, 80 and 33% of the rats survived 7 days after ischemia in the study and control groups, respectively. The control animals showed deterioration of the tubules function, high enzymuria. Thus, it is possible to raise kidney tolerance to ischemia by preischemic parenteral injection of sodium hypochlorite solution.

Adaptation, Physiological↗
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[Change in indicators of metabolism and kidney function in intact rats after parenteral administration of sodium hypochlorite].

The changes of kidney metabolism, function and enzymuria activity of nephron epithelium cells after 4 days of parenteral administration of sodium hypochlorite 0.02% and 0.06% solutions were investigated in the experiments on 15 intact non-inbred rats of 200-280 g body weight. It was revealed that sodium hypochlorite induced metabolic damage to the kidney similar to ischemic one. The 0.02 and 0.06% solutions of sodium hypochlorite administered parenterally produced no negative effect on renal function. There was no significant rise of enzymuria activity in experimental groups compared to the controls. Moreover, enzymuria of four from six nephron epithelium cell enzymes decreased significantly to day 5 of the experiment. Metabolic damage and enzymuria activity changes were more pronounced in rats given parenteral 0.06% solution of sodium hypochlorite.

Animals↗
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[Indirect electrochemical blood oxidation in the prophylaxis of suppurative-inflammatory complications after transurethral resection of the prostate].

To investigate efficiency of indirect electrochemical blood oxidation in prophylaxis of infectious complications, 28 patients were treated with 0.06% hypochlorite solution (2 infusions, 2-3 days before TURP). These patients belonged to a high-risk group of infectious complications (80% of them had chronic prostatitis, 8 patients had bladder stones, 8 had undergone cystostomy). The results demonstrated that the complication rate in the above prepared patients fell four times as compared to the control group and the postoperati hospital stay was reduced by 3 days.

Aged↗
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[Kidney involvement in acute occlusion of the bifurcation of the aorta and the major arteries of the lower extremities].

A total of 162 patients with acute thromboses and embolism of bifurcation of the aorta and the major vessels of the extremities were studied for renal performance before and after the corrective surgery. In this line the values of central hemodynamics, electrolytic balance, acid-base composition of blood and the hemostatic system were investigated. The author established the relation between the renal dysfunction and the character of the underlying disease which was the cause of thromboses or embolism, the level of occlusion and the degree of ischemic lesions in the extremity mainly. It was revealed that in case of an increase in the ischemic lesion of the extremity, the kidney performance decreased. In patients with recovered blood flow in the extremities, the failure of the renal function was developing due to the inclusion syndrome. The author distinguished three stages of the syndrome severity and related functional disorders of the kidneys. Renal dysfunction should be corrected even in case of mild ischemic lesions. The authors presented the principles of their correction as well. Acute renal failure can be regarded as a death cause only in 7.7% of expired persons who had acute thromboses of arterial embolism. The author came to the conclusion that in patients with the recovered blood flow pathological changes in the morphology and functioning of the kidneys were mainly associated with the disorders in renal hemodynamics, the mechanical blockage of tubules by myoglobin degradation products, decompensated metabolic acidosis, disseminated intravascular coagulation syndrome and immediate exposure of the renal parenchyma to toxins of protein nature.

Acute Disease↗
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[The state of the blood prekallikrein-kallikrein system in patients with acute arterial obstruction of legs].

Distinct activation of the blood prekallikrein-kallikrein system was detected in patients with acute thromboses and embolism of aorta bifurcation and of leg magistral arteries. The rate of activation depended on the form of main disease responsible for acute arterial obstruction as well as on severity of legs ischemic impairments. Measurement of the blood prekallikrein-kallikrein system parameters enabled to evaluate more efficiently the severity of initial steps of legs ischemic impairments in patients with acute arterial occlusions as well as to predict the restorative operations success.

Acute Disease↗
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[Is reconstructive surgery the key to solving the problem of acute thrombi in the arteries of the extremities of atherosclerotic etiology?].

Long-term results (up to 3 years) of reconstructive-restorative operations on 52 patients with acute thromboses of extremity arteries of atherosclerotic etiology are analyzed. Results of lumbar sympathectomy were followed in 17 patients who had lesions of the distal bed of the extremity preventing reconstructive-restorative operations. Results of operative measures at remote periods were not very comforting. The results can be improved by perfecting the dispensary observation of the patients, detection of latent forms of vascular insufficiency which can be treated conservatively as well as prophylactics and treatment of atherosclerosis.

Acute Disease↗
PubMedDate not supplied

[The use of the descending genicular artery for long-term intra-arterial infusion in chronic ischemia of the extremities].

The authors have developed a method of continuous intraarterial infusion of drugs by catheterization of the descending artery of the knee and used it in complex treatment of 11 patients with diabetic microangiopathy of lower extremities complicated by pyo-necrotic lesions of the foot and 6 patients with aorto-iliac segment and III stage ischemia of the foot. The method was shown to be highly efficient as compared with the control group.

Aged↗
PubMedDate not supplied

[Effects of indirect electrochemical blood oxidation by sodium hypochlorite solution on the course on inflammatory process in the kidneys and urinary tract].

The action of indirect electrochemical blood oxidation with 0.06% solution of sodium hypochlorite on kidney and urinary inflammation was studied in experiments on 60 non-inbred rat females of 200-250 g body weight. The animals were intravesically infected through the catheter with E. coli and Ps. aeruginosa. 3 days later, after histological verification of acute pyelonephritis, ureteritis, cystitis, the animals were injected intraperitoneally 1.0 and 2.0 ml daily of sodium hypochlorite solution (control animals) or 0.89% solution of sodium chloride. Though no reliable decrease of the bacterial contamination was achieved, histologically, there was a marked reduction in morphological signs of the inflammation in the kidneys, ureter and urinary bladder on the first day after beginning of electrochemical blood oxidation with solution of sodium hypochlorite in experimental groups. In experimental group rats morphological signs of urinary and renal inflammation for both infections disappeared on days 7 and 10, respectively. In the control animals morphological signs of the inflammation remained after 10 days. Moreover, purulent inflammation was registered in the controls infected with Ps. aeruginosa.

Animals↗