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V V Klimenko

Publications and source records attributed to V V Klimenko.

29 records · Page 2Linked to original sources
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Functional genetic damages and their possible role in the aging of eukaryote cells.

As a result of investigations of the functional acitivty of eukaryote cells damaged by ionizing radiation and alkylating mutagens under conditions of extreme loading, the authors have suggested that natural aging and aging accelerated by mutagens are based on a process of accumulation of functional genetic damages. The molecular nature of these damages differs from the mutational changes and repairable damages of DNA.

Aging↗
PubMedDate not supplied

[Detection in the bile of a specific Fasciola hepatica antigen, a diagnostic criterion of fascioliasis].

The antigen activity of bile of rabbits, sheep and cattle infected with F. hepatica was investigated by the immunodiffusion methods. The sera obtained from animals with experimental fasciolosis and other infections were used. At the experimental fasciolosis and intensive natural infection antigens were found in bile, one of which was present in all the animals and turned to be identical immunologically to the specific protein antigene (molecular weight is 27 500) isolated from the extract of F. hepatica. Titres of this antigene in bile depended usually on the infection intensity and were, as a rule, higher than titres of corresponding antibodies in the blood serum. The presence of this antigen in bile can serve as a diagnostic indication of fasciolosis especially when ovoscope or immunological methods based on the finding of antibodies are inefficient.

Animals↗