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V V Potin

Publications and source records attributed to V V Potin.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[Effect of proton irradiation of the hypophysis on its gonadotropic and thyrotropic functions in patients with prolactinoma].

In order to study the effect of proton beam irradiation on prolactinoma cells and hypophyseal intact cells tests with i.v. administration of TRH (200 micrograms) and LH-RH (100 micrograms) were performed in 16 women with prolactin-secreting adenomas before and in 2 mos.-2 years after irradiation of the pituitary body with a high energy narrow proton beam (1000 MeV) at a dose of 40-120 Gy. A curative therapeutic effect of proton therapy which was low with respect to reproductive function recovery, was combined with lowered functional reserves of hypophyseal thyrotrophs and gonadotrophs. The informative value of the tests with the releasing hormones was shown for the determination of damage of hypophyseal intact cells. The results suggest refractivity of adenomatous lactotrophs to radiation exposure and the hypothalamic level of disorder of ovarian function regulation in this pathology.

Adult↗
PubMedDate not supplied

[Gonadotropic activity of the hypophysis and ovarian endocrine function in hyperprolactinemic amenorrhea].

Radioimmunoassays were used repeatedly to determine prolactin, LH, FSH, estradiol and progesterone at different time intervals (days, months, weeks) in 50 women with hyperprolactinemic amenorrhea. Nine patients had x-ray signs of hypophysial adenoma. The intact state of the portal system, hypophysis gonadotrophs and thyrotrophs was confirmed using LH-RH and TRH tests. Proceeding from the comparison of gonadotrophin and sex steroids and the analysis of the blood LH fluctuation amplitude after repeated measurements, it was concluded that the gonadotropic basal secretion was disturbed in hyperprolactinemic amenorrhea and that a single determination of an elevated gonadotrophin level in the blood was not enough to diagnose primary ovarian insufficiency.

Adult↗
PubMedDate not supplied

[Dopamine in the pathogenesis of normogonadotropic amenorrhea].

A total of 108 patients with normo-gonadotropic amenorrhea and 25 normal females were investigated. Three dopamine-dependent parameters were under study: maximum range of changes in the blood levels of luteinizing hormone (LH) and follicle-stimulating hormone, hypophyseal response to thyrotropin releasing factor (TRF) and prolactinemia-dependent therapeutic effect of bromocriptine. Significantly increased range of the serum gonadotropin levels, increased reaction of hypophyseal thyrotropic hormone to TRF and higher therapeutic efficiency of bromocriptine was revealed in hyperprolactinemic patients versus those with normo-gonadotropic amenorrhea. The results obtained are indicative of the decreased dopaminergic tension of the tuberoinfundibular system in hyperprolactinemic amenorrhea and increased one in normoprolactinemic patients. In 15 out of 32 normoprolactinemic patients bromocriptine therapy normalized their menstrual cycles. The range of spontaneous changes in the blood levels of LH was supposed to be a prognostic criterion for the assessment of bromocriptine therapeutic efficiency. A relative hypophyseal deficiency of dopamine was suggested in some of normoprolactinemic patients.

Adolescent↗
PubMedDate not supplied

[Treatment of diffuse toxic goiter with radioactive iodine in combination with prolonged antithyroid therapy].

The authors analyzed clinically the results of treatment of 237 patients with diffuse toxic goiter with radioactive iodine in combination with prolonged antithyroidal therapy (12--18 months). The advantages of combined therapy consisted in the use of relatively low 131I doses, a great frequensy of clinical remissions of thyrotoxicosis (83%), in the absence of thyrotoxicosis remissions after the administration of a low radioactive iodine dose and a low percentage of stable hypothyroidism development (0.8%) as a complication of radioiodine therapy.

Adult↗
PubMedDate not supplied

[Functional reserves of the thyroid gland in thyrotoxicosis remission].

A test with intramuscular injection of 5 or 10 U of TTH was carried out in 47 patients suffering from diffuse toxic goiter, including 34 cases at the stage of thyrotoxicosis remission. Results of this test were evaluated by the changes of I131 absorption by the thyroid gland and of the blood protein-bound iodine level. The thyroid gland TTH sensitivity was found to be diminished in 16 patients with thyrotoxicosis remission. The reaction was absent most regularly in patients with ophthalmopathy. This denotes a latent form of thyroid insufficiency and suggest that the patients with the negative response to the exogenous TTH are in the "risk group" in respect to the development of manifest hypothyroidism.

Adult↗