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Biomedical subjects

V V Potin

Publications and source records attributed to V V Potin.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Impulse secretion of gonadotropins in patients with various forms of amenorrhea].

Circahoral variations of gonadotropin secretion were investigated in 5 healthy women in the follicular phase of the menstrual cycle, in 8 patients with normogonadotropic amenorrhea, in 6 patients with hyperprolactinemic amenorrhea, in 4 patients with hypogonadotropic amenorrhea, and in 10 patients with amenorrhea associated with body mass deficiency. The levels of LH, FSH, prolactin, estradiol and progesterone were determined by radioimmunoassay every 20 min for 4 hours. The results suggest that the blood levels of gonadotropins in different types of amenorrhea are determined mainly by an amplitude of their impulses.

Adolescent↗
PubMedDate not supplied

[The clinico-pharmacological characteristics of anteovin].

The clinical and laboratory studies carried out on 160 women showed a high contraceptive effect and good tolerance of anteovine. The contraceptive effect of the biphasic drug is determined by its antiovulatory action concurrent with inhibition of the basal periovulatory secretion of gonadotropins and secretion of sex hormones.

Adolescent↗
PubMedDate not supplied

[The reaction of the hypophysis to thyroliberin and metoclopramide in women with hyperprolactinemia].

Functional tests with i.v. injection of metoclopramide (10 mg) and thyroliberin (200 micrograms) with a record of PRL and TSH levels for 120 min. were performed in 87 women of reproductive age (19 healthy nonpregnant women, 9 women in the early postnatal period, 10 patients with primary hypothyroidism, and 30 patients with PRL secreting chromophobe adenomas). Hyperprolactinemic anovulation was noted in 35 examinees. Comparison of the results of thyroliberin and metoclopramide tests in different groups of examinees was suggestive of a decrease in dopaminergic inhibition of the hypophysis in postnatal and adenomatous hyperprolactinemia. The presence and a degree of hyperprolactinemia in patients with primary hypothyroidism depends, probably, on the ratio of a stimulating effect of endogenous thyroliberin and inhibitory action of dopamine on hypophyseal lactotrophs.

Adult↗
PubMedDate not supplied

[Antigens of the HLA system in different types of diabetes mellitus].

HLA antigens (A, B, DR) of the tissues of 171 patients with different types of diabetes mellitus were investigated. Controls were 1867 healthy Leningrad residents (control I), not investigated with the GTT, and 38 pregnant women with the unchanged GTT during pregnancy (control II). Some features of the frequency of occurrence of individual antigens and their interlocular (HLA A, B) combinations in type I and type II diabetes mellitus and diabetes of pregnant women were established. The risk of diabetes mellitus, type I, development was shown to be on the increase in the presence of HLA DR4 in the phenotype and considerably on the decrease in the presence of HLA B17. The results point out to the genetic heterogeneity of different types of diabetes mellitus. The authors think it possible to use HLA typing for the diagnosis of type I diabetes mellitus.

Adolescent↗
PubMedDate not supplied

[Gonadotropic insufficiency in men with disorders of spermatogenesis].

The results of the investigation of 111 male patients with azoospermia, oligozoospermia and asthenoteratozoospermia revealed gonadotropic insufficiency in 28 (25.2%). The mean level of LH in the peripheral blood of the patients (4.36 +/- 0.70 IU/l) did not differ significantly from the indices in the control group (5.71 +/- 0.64 IU/l). The blood FSH level (0.86 +/- 0.13 IU/l) was significantly lower than the control one (4.48 +/- 0.44 IU/l), p less than 0.001. The level of testosterone in 14 patients was within normal. The clinical signs of hypogonadism were slightly expressed, gynecomastia and anosmia were absent. In 6 of 11 patients the response of FSH to LH-RH i. v. injection was either absent or sharply decreased. The LH response was absent in 2 patients. A conclusion has been made that disorder of spermatogenesis can be the only noticeable manifestation of isolated insufficiency of FSH secretion by the pituitary gland.

Follicle Stimulating Hormone↗
PubMedDate not supplied

[The effect of metoclopramide on the hypophyseo-ovarian relations in patients with amenorrhea resulting from body mass loss].

The levels of FSN, LH, prolactin, estradiol, and progesterone were investigated in the blood of 26 women with hypothalamic amenorrhea (in 17 of them it resulted from body mass deficiency) before and during metoclopramide therapy (the drug was administered at a daily dose of 20 mg for 1 = 9 mos). The administration of the drug per os in 3 h resulted in a considerable rise of the blood level of prolactin in patients with body mass deficiency. Regular administration of the drug in this group normalized the anovulatory cycle in 5 women and caused pregnancy in one woman. In the authors opinion, this effect was due to a decrease in dopaminergic inhibition of the anterior pituitary lobe and the restoration of the mechanism of positive feedback between the ovaries and pituitary gland.

Adolescent↗